Reconstruction of long-range axonal projections by restoring neuronal activity
| Project/Area Number |
23500388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto University |
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Principal Investigator |
TAGAWA Yoshiaki 京都大学, 理学(系)研究科(研究院), 講師 (50303813)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 大脳皮質 / 回路形成 / 神経活動 / 軸索投射 / 再生 |
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| Research Abstract |
Brain circuits are formed by activity-independent and -dependent mechanisms. In this project, we found that long-range axonal projections in the mouse cerebral cortex rely on neuronal activity, and that impaired axonal projections caused by activity reduction can be recovered by restoring neuronal activity.The involvement of specific patterns of activity was suggested. In addition, we found that neurons at each developmental stage require an appropriate level of neuronal activity for their maturation. Neurons in the course of migration showed spontaneous calcium transients at a low frequency, and an experimental increase of the activity impeded migration. After neurons completed migration, however, they showed more frequent calcium transients which supported their maturation such as dendrite formation.
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Report
(4 results)
Research Products
(38 results)
