| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Glutamategic neurons are produced through life in the hippocampus. However, mechanism determining subtype selection of newborn neurons has not been elucidated. Here, we showed that extracellular nucleotides induced glutamatergic subtype markers in the newborn neurons. Pharmacological study indicated the receptor corresponding to the nucleotide-induced glutamagergic differentiation. Expression of the corresponding receptor was transiently augmented in the course of neuronal differentiation of mouse ES cells in vitro. The augmentation was coincident with the period when nucleotide can induce glutamatergic subtype markers. These results indicate that extracellular nucleotides can contribute to the glutamatergic subtype selection of newborn neurons.
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