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Central neuromodulators and decision making

Research Project

Project/Area Number 23500393
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neuroscience in general
Research InstitutionFukushima Medical University

Principal Investigator

KOBAYASHI Shunsuke  福島県立医科大学, 医学部, 助教 (30579272)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsドパミン / アセチルコリン / 報酬 / 空間性注意 / 意思決定 / 半側空間無視 / 高次脳機能障害 / 視覚弁別 / 視覚性注意 / 神経伝達物質 / 動機づけ
Research Abstract

Motivation and attention play an important role in flexible and efficient decision making. We investigated the effects of dopaminergic and acetylcholinergic drugs on the performance of visual discrimination. In control subjects, l-dopa and donepezil both improved performance of visual discrimination. In right brain damage patients, left hemispatial neglect was ameliorated by both l-dopa and donepezil. The results suggest that both dopaminergic and acetylcholinergic systems are involved in visual processing.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Reward contexts extend dopamine signals to unrewarded stimuli2014

    • Author(s)
      Shunsuke Kobayashi, Wolfram Schultz
    • Journal Title

      Current Biology

      Volume: 24 Issue: 1 Pages: 56

    • DOI

      10.1016/j.cub.2013.10.061

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quadri-pulse stimulation induces stimulation frequency dependent cortical hemoglobin concentration changes within the ipsilateral motor cortical network2013

    • Author(s)
      Groiss SJ, Mochizuki H, Furubayashi T, Kobayashi S, Nakatani-Enomoto S, Nakamura K, Ugawa Y.
    • Journal Title

      Brain Stimul

      Volume: 6 Issue: 1 Pages: 40

    • DOI

      10.1016/j.brs.2011.12.004

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Organization of neural systems for aversive information processing: Pain, error, and punishment2012

    • Author(s)
      S Kobayashi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 6;136 Issue: SEP Pages: 1-9

    • DOI

      10.3389/fnins.2012.00136

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuronal signals for reward risk in frontal cortex2012

    • Author(s)
      Shultz W, O'Neill M, Tobler P, Kobayashi S
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1239 Issue: 1 Pages: 109

    • DOI

      10.1111/j.1749-6632.2011.06256.x

    • URL

      https://localhost/en/publications/f57ea8fb-4b90-4524-b003-a823f28de204

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ドパミンと情動認知機能2012

    • Author(s)
      小林 俊輔
    • Journal Title

      Annual Review 神経 2012

      Volume: 1 Pages: 8-16

    • Related Report
      2012 Research-status Report
  • [Journal Article] ドパミンと情動認知機能2012

    • Author(s)
      小林俊輔
    • Journal Title

      Annual Review 神経 2012

      Volume: 1 Pages: 8-16

    • Related Report
      2011 Research-status Report
  • [Journal Article] Widespread muscle involvement in critical illness myopathy revealed by MRI.2011

    • Author(s)
      Matsuda N, Kobayashi S, Tanji Y, Hasegawa A, Tase C, Ugawa Y.
    • Journal Title

      Muscle and Nerve

      Volume: 44 Pages: 842-844

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Some evidence supporting the safety of quadripulse stimulation (QPS).2011

    • Author(s)
      Nakatani-Enomoto S, Hanajima R, Hamada M, Mochizuki H, Kobayashi S, Enomoto H, Sugiura Y, Matsumoto H, Furubayashi T, Terao Y, Sato F, Ugawa Y
    • Journal Title

      Brain Stimul

      Volume: 4 Pages: 303-305

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuronal signals for reward risk in frontal cortex.2011

    • Author(s)
      Schultz W, O'Neill M, Tobler PN, Kobayashi S
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1239 Pages: 109-117

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ドパミン、アセチルコリンと可塑性2011

    • Author(s)
      小林俊輔
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 769-772

    • Related Report
      2011 Research-status Report
  • [Presentation] Financial risk attitude in Parkinson's disease patients2013

    • Author(s)
      Kobayashi S, Matsuda N, Akutsu Y, Ugawa Y
    • Organizer
      Annual meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2013-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Activities in primate striatum and prefrontal cortex during memory-guided and reward-guided saccades2011

    • Author(s)
      Kobayashi S
    • Organizer
      16th European Conference of Eye Movement.(招待講演)
    • Place of Presentation
      Marseill, France
    • Related Report
      2011 Research-status Report
  • [Presentation] パーキンソン病における報酬選択行動の心理学的検討

    • Author(s)
      小林俊輔, 松田希, 阿久津由紀子, 宇川義一
    • Organizer
      日本神経心理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] パーキンソン病における報酬選択行動の心理学的検討

    • Author(s)
      小林俊輔、松田希、阿久津由紀子、宇川義一
    • Organizer
      日本神経心理学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Financial risk attitude in Parkinson disease patients

    • Author(s)
      Shunsuke Kobayashi, Nozomu Matsuda, Yukiko Akutsu, Yoshikazu Ugawa
    • Organizer
      Annual meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 報酬文脈と視覚刺激の顕著性がドパミン活動に及ぼす影響

    • Author(s)
      小林俊輔
    • Organizer
      日本大脳基底核研究会
    • Place of Presentation
      修善寺
    • Related Report
      2013 Annual Research Report
  • [Book] Peripheral Neuropathy2012

    • Author(s)
      Matsuda N, Kobayashi S, Ugawa Y
    • Total Pages
      20
    • Publisher
      InTech
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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