Mechanisms involved in age-related memory impairment and sleep in Drosophila
Project/Area Number |
23500394
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neuroscience in general
|
Research Institution | Tokyo Metropolitan Institute of Medical Science (2013) Tokyo Metropolitan University (2011-2012) |
Principal Investigator |
HORIUCHI Junjiro 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主席研究員 (80392364)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 学習 / 記憶 / 加齢性記憶障害 / 睡眠 / ショウジョウバエ / 長期記憶 / 老化 / シナプス可塑性 |
Research Abstract |
As we age, we suffer a decrease in memory. This phenomenon is known as age-related memory impairment (AMI). AMI is a serious social and medical problem, and it becomes more severe as we age. To understand the causes of AMI, we studied it in Drosophila. We found that aging causes an increase in a protein, pyruvate carboxylase (PC). PC is found in glia, cells that interact with neurons. Increasing PC activity in glia inhibits production D-serine, a neuromodulator that regulates neuronal activity. Feeding D-serine to old flies decreases AMI. This indicates that decreased glial production of the neuromodulator D-serine is a cause of AMI. In a second project, we studied sleep in Drosophila. Sleep is essential for many organisms, but its regulation is still unclear. We found that sleep is regulated by the Ca2+/calmodulin signaling pathway, a pathway known to control many biological processes. Our results suggest a mechanism through which sleep may be linked to other biological processes.
|
Report
(4 results)
Research Products
(24 results)
-
[Journal Article] Fasting launches CRTC to facilitate long-term memory formation in Drosophila2013
Author(s)
Hirano, Y., Masuda, T., Naganos, S., Matsuno, M., Ueno, K., Miyashita, T., Horiuchi, J., Saitoe, M
-
Journal Title
Science
Volume: 339(6118)
Pages: 443-6
Related Report
Peer Reviewed
-
-
[Journal Article] Fasting launches CRTC to facilitate long-term memory formation in Drosophila.2013
Author(s)
Hirano, Y., Masuda, T., Naganos, S., Matsuno, M., Ueno, K., Miyashita, T., Horiuchi, J., Saitoe, M.
-
Journal Title
Science
Volume: 339
Issue: 6118
Pages: 443-446
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Mg^<2+> block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression2012
Author(s)
Miyashita, T., Oda, Y., Horiuchi, J., Yin, J. C-P., Morimoto, T., Saitoe, M
-
Journal Title
Neuron
Volume: 74(5)
Pages: 887-98
Related Report
Peer Reviewed
-
-
-
[Journal Article] Mg2+ block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression.2012
Author(s)
Miyashita, T., Oda, Y., Horiuchi, J., Yin, J. C-P., Morimoto, T., Saitoe, M.
-
Journal Title
Neuron
Volume: 74
Issue: 5
Pages: 887-898
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Mg2+ block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression2012
Author(s)
Miyashita, T., Oda, Y., Horiuchi, J., Yin, J. C-P., Morimoto, T., Saitoe, M.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Calcineurin and its regulator Sra/DSCR1 are essential for sleep in Drosophila2011
Author(s)
Nakai, Y., Horiuchi, J., Tsuda, M., Takeo, S., Akahori, S., Matsuo, T., Kume, K., Aigaki, T
-
Journal Title
J Neurosci
Volume: 31(36)
Pages: 12759-12766
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-