| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Sexual differentiation of the brain can be considered as a process during which effects of sex steroid hormones during development are maintained into adulthood. Epigenetic regulation is emerging as an important mechanism of lasting effects of the hormonal milieu in the developing brain. Evidence has accumulated hat epigenetic regulation is involved in sexual differentiation of the brain. Epigenetic regulation occurs via different mechanisms, and interactions between histone modifications and DNA methylation have been suggested. There may be some synergistic and/or hierarchical interactions among the epigenetic modifications that control sexual differentiation of the brain. In this research, it was examined whether interactions among different epigenetic mechanisms are involved in sexual differentiation of the brain, and founded that the hierarchical order among epigenetics mechanisms (i.e., histone acetylation-deacetylation, and then DNA methylation) existed in its early process.
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