Neural basis of human decision-making; Analysis in de novo Parkinson disease patients by neuroeconomic task
| Project/Area Number |
23500398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TABUCHI Hajime 慶應義塾大学, 医学部, 講師 (10286578)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | パーキンソン病 / 神経経済学 / 行動神経科学 / 意思決定 / 機能的MRI検査 / 倫理判断 |
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| Research Abstract |
THE DISRUPTION OF VENTRAL STRIATUM AND AMYGDALA ACTIVITY TO FINANCIAL CUES IN NEVER-MEDICATED PARKINSON DISEASE PATIENTS.
Objectives: This study investigated the altered neural processes underlying behavioral responses in never-medicated PD patients by using a neuroecomonics task in conjunction with functional magnetic resonance imaging. Methods: The de novo PD patients (n = 9) and age matched healthy controls (n = 8) performed a modified monetary incentive delay task. Results: The activity of ventral striatum and amygdala to financial cues was reduced in untreated de novo PD patients. PD patients in the early stage might show the dual reduced brain activities, including the hypoactivity of ventral striatum constituting the brain reward system and the dysfunction of amygdala that may play a key role in loss aversion. In PD, the dysfunction in ventral striatum and amygdala may be present from onset, and represent a behavioral endophenotype, prior to dopaminergic treatment.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Clinical features and varieties of non-motor fluctuations in Parkinson’s disease: A Japanese multicenter study.2013
Author(s)
Seki M, Takahashi K, Uematsu D, Mihara B, Morita Y, Isozumi K, Ohta K, Muramatsu K, Shirai T, Nogawa S, Gotoh J, Yamaguchi K, Tomita Y, Yasutomi D, Nihei N, Iwasawa S, Suzuki N
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Journal Title
Parkinsonism & Related Disord.
Volume: 19
Issue: 1
Pages: 104-108
DOI
Related Report
Peer Reviewed
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[Journal Article] REM Sleep Behavior Disorder in Japanese Patients with Parkinson's Disease: A Multicenter Study Using the REM Sleep Behavior Disorder Screening Questionnaire.2012
Author(s)
Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, Ohta K, Muramatsu K, Gotoh J, Yamaguchi K, Tomita Y, Sato H, Seki M, Iwasawa Y, Suzuki N
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Journal Title
Journal of Neurology
Volume: 259
Issue: 8
Pages: 1606-1612
DOI
Related Report
Peer Reviewed
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[Journal Article] Camptocormia in Japanese patients with Parkinson's disease: a multicenter study.2011
Author(s)
Seki M, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, Ohta K, Muramatsu K, Gotoh J, Yamaguchi K, Tomita Y, Sato H, Nihei Y, Iwasawa S, Suzuki N; Keio Parkinson's Disease Database.
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Journal Title
Mov Disord.
Volume: 26
Issue: 14
Pages: 2567-2571
DOI
Related Report
Peer Reviewed
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[Presentation] REM sleep behavior disorder in Japanese patients with Parkinson’s disease: A multicenter study using REM sleep behavior disorder questionnaire.2011
Author(s)
Nihei Y, Koto A, Mihara B, Morita Y, Isozumi K, Ohta K, Muramatsu K, Takahashi K, Gotoh J, Yamaguchi K, Tomita Y, Sato H, Seki M, Iwasawa S and Suzuki N
Organizer
15th International Congress of Parkinson’s Disease and Movement Disorders
Place of Presentation
Toronto, Canada
Related Report
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[Presentation] Screening utility of Montreal Cognitive Assessment (MoCA) for detecting cognitive impairment in patients with Parkinson’s disease.
Author(s)
Seki M, Kobari M, Mihara B, Isozumi K, Ohta K, Muramatsu K, Shirai T, Takahashi K, Nozaki H, Gotoh J, Yamaguchi K, Tomita Y, Sato H, Yasutomi D, Nihei Y, Iwasawa S, Suzuki N
Organizer
16th International Congress of Parkinson’s Disease and Movement Disorders
Place of Presentation
Dublin, Ireland
Related Report
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[Presentation] MMSEが正常のパーキンソン病患者の認知機能障害検出のためのMoCA-Jの有用性の検討
Author(s)
関 守信, 鈴木則宏, 小張昌宏, 美原 盤, 五十棲一男, 太田晃一, 村松和浩, 白井俊孝, 高橋一司, 野崎博之, 後藤 淳, 山口啓二, 冨田 裕, 佐藤秀樹, 安富大祐, 二瓶義廣, 岩澤聡子
Organizer
第53回 日本神経学会学術大会
Place of Presentation
東京フォーラム、東京都
Related Report
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[Presentation] パーキンソン病におけるREM睡眠行動異常症認知機能・抑うつに関する多施設共同研究
Author(s)
関 守信, 鈴木則宏, 小張昌宏, 美原 盤，五十棲一男, 太田晃一, 村松和浩, 白井俊孝, 高橋一司, 野崎博之, 後藤 淳, 山口啓二, 冨田 裕, 佐藤秀樹, 安富大祐, 二瓶義廣, 岩澤聡子
Organizer
第6回パーキンソン病・運動障害疾患コングレス（MDSJ）
Place of Presentation
京都ホテルオークラ、京都
Related Report
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[Presentation] パーキンソン病におけるREM睡眠行動異常症の経時的変化
Author(s)
二瓶義廣, 鈴木則宏, 厚東篤生, 小張昌宏, 美原 盤，森田陽子, 五十棲一男, 太田晃一, 村松和浩, 白井俊孝, 高橋一司, 野崎博之, 後藤 淳, 山口啓二, 冨田 裕, 佐藤秀樹, 安富大祐, 関 守信, 岩澤聡子
Organizer
第6回パーキンソン病・運動障害疾患コングレス（MDSJ）
Place of Presentation
京都ホテルオークラ、京都
Related Report
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