Regulatory mechanism of circuit remodeling after nerve injury
| Project/Area Number |
23500400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MIYATA MARIKO 東京女子医科大学, 医学部, 教授 (70281631)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 視床 / 抑制系入力 / tonic GABA 受容体 / 内側毛帯線維 / リモデリング / 神経損傷 / ウイルスベクター / 神経可塑性 / 内側毛帯繊維 / 眼窩下神経 / 神経切断 |
|---|
| Research Abstract |
The rodent ventral posterior medial (VPm) nucleus receives an excitatory input via the medial lemniscal synapse. In addition, the VPm also receives nearly all of the inhibitory inputs from the thalamic reticular nucleus (TRN). We previously reported that the complete transection of the infraorbital nerve (ION)resulted in multiple innervation of medial lemniscal fibers onto a VPm neuron around 5 days after operation (POD5) . However, it remains still unclear the postoperative change of inhibitory inputs onto VPm neurons after the transection of ION. ION cutreduced the amplitude of evoked-inhibitory postsynaptic currents (eIPSCs).Interestingly, in contrast, tonic GABA currents onto VPm neurons rapidly increased by the transection of the ION at POD1. At POD7, tonic GABA currents also increased in VPm neurons, which had multiple lemniscal fibers by the transection of ION. Thus, inhibitory input change may interact with the remodeling of lemniscal fibers.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Synaptic targeting of mGluR1 by carboxyl-terminal domain is crucial for cerebellar function2014
Author(s)
Ohtani Yoshiaki, Miyata Mariko(Co first author), Hashimoto Kouichi, Tabata Toshihide, Kishimoto Yasushi, Fukaya Masahiro, Kase Daisuke, Kassai Hidetoshi, Nakao Kazuki, Hirata Tatsumi, Watanabe Masahiko, Kano Masanobu, and Aiba Atsu
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Journal Title
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume: 34(7)
Pages: 2702-2712
Related Report
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[Journal Article] The synaptic targeting of mGluR1 by its carboxyl-terminal domain Is crucial for cerebellar function2014
Author(s)
Yoshiaki Ohtani, Mariko Miyata, Kouichi Hashimoto, Toshihide Tabata, Yasushi Kishimoto, Masahiro Fukaya, Daisuke Kase, Hidetoshi Kassai, Kazuki Nakao, Tatsumi Hirata, Masahiko Watanabe, Masanobu Kano, Atsu Aiba
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Journal Title
Journal of Neuroscience
Volume: 34
Issue: 7
Pages: 2702-2712
DOI
Related Report
Peer Reviewed
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