| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Various plasma membrane proteins play important roles in the processes of synaptogenesis, as well as synaptic maintenance and plasticity. We are exploring the key functions of such proteins using Drosophila neuromuscular junctions (NMJ). In the present study, we focused on Toll family proteins. By the phenotype analyses of genetic overexpression or loss-of-function mutation, we found that Toll-7 functions as a negative regulator of NMJ development and maintenance. On the other hand, we have not observed the impairment of synaptic morphology by genetic RNAi of Spz family proteins, the putative ligand of Toll family proteins.
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