| Project/Area Number |
23500415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Hirotaka 岡山大学, 大学院・自然科学研究科, 准教授 (20363971)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子神経生物学 / 攻撃行動 / 性行動 / グルタミン酸 / mGluR7 / 社会行動 / aggression / social behavior / sexual behavior / GRP / 嗅覚 / c-fos / BNST |
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| Research Abstract |
Metabotropic glutamate receptor subtype 7 (mGluR7) is a member of group III mGluRs, which locates in the presynaptic active zones. Using a resident-intruder paradigm, we found a severe impairment of aggression in mGluR7 knockout (KO) mice. Since olfaction is known to be a critical component for aggressive behavior, we further employed an olfaction test and found altered urine preference in mGluR7 KO mice. Then, to clarify the olfactory processing, we analyzed c-Fos-immunoreactivity after exposure to urine, and found a remarkable reduction of neuronal activity in the bed nucleus of the stria terminalis (BNST) of mGluR7 KO mice. Finally, intra-BNST administration of the mGluR7-selective antagonist 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP) also impaired aggression. These results indicate that mGluR7 works as an enhancer of excitation in the BNST and is essential to evoke olfaction-based aggressive behavior.
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