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The role of olig2-derived astrocytes in subthalamic nucleus of adult mouse

Research Project

Project/Area Number 23500416
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionNara Medical University

Principal Investigator

TATSUMI Kouko  奈良県立医科大学, 医学部, 准教授 (90208033)

Co-Investigator(Kenkyū-buntansha) WANAKA Akio  奈良県立医科大学, 医・第2解剖学講座, 教授 (90210989)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsアストロサイト / Olig2 / 大脳基底核 / 視床下核 / パーキンソン氏病 / olig2 / 抑制性ニューロン / ドパミン / パーキンソン病 / チャネルロドプシン / GFP
Research Abstract

In this study, we found that Olig2 positive cells constitute a subpopulation of astrocytes in the adult mouse forebrain and distribute specifically in the basal ganglia including subthalamic nucleus (STN) and the globus pallidus. It is well known that these two nuclei are target areas for deep brain stimulation (DBS) in Parkinson's disease. To know the property of Olig2-astrocyte in the area, we made a hemi-Parkinson's disease model using Olig2CreER: ROSA-GAP43-EGFP double transgenic mouse. Upon apomorphine injection, the mice exhibited rotation behaviors that reflected imbalance of dopaminergic activities. In this experimental paradigm, we found that Olig2-astrocyte had more complex bushy morphologies in the activated side of the basal ganglia, especially in the STN than in the contralateral side. These findings suggest that morphologies of astrocytes are closely related to neuronal activities in the basal ganglionic nuclei.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 1 results)

  • [Journal Article] OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex2014

    • Author(s)
      Okuda H, Tatsumi K, Horii-Hayashi N, Morita S, Okuda-Yamamoto A, Imaizumi K, Wanaka A
    • Journal Title

      J Neurochem

      Volume: Epub ahead Issue: 5 Pages: 612-25

    • DOI

      10.1111/jnc.12736

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes2014

    • Author(s)
      Okuda H, Tatsumi K, Morita S, Shibukawa Y, Korekane H, Horii-Hayashi N, Wada Y, Taniguchi N, Wanaka A.
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 5 Pages: 2620-2631

    • DOI

      10.1074/jbc.m113.504787

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 神経活動にともなうアストロサイトの形態変化2014

    • Author(s)
      辰巳晃子
    • Organizer
      第119回日本解剖学会総会・シンポジウム( グリア細胞研究の最前線)
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経活動にともなうアストロサイトの形態変化2014

    • Author(s)
      辰巳晃子
    • Organizer
      日本解剖学会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Inhibition of astrocyte metabolisms in the basal ganglionic nuclei lowers voluntary motor activities in adult mice2013

    • Author(s)
      辰巳晃子
    • Organizer
      第118回日本解剖学会総会
    • Place of Presentation
      香川国際会議場(高松)
    • Related Report
      2013 Final Research Report
  • [Presentation] Astrocytic morphologies in the basal ganglionic nuclei are closely related to motor activities in adult mice2013

    • Author(s)
      辰巳晃子
    • Organizer
      第36回日本神経科学大会, 第56回日本神経化学会大会, 第23回日本神経回路学会 合同学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Astrocytic morphologies in the basal ganglionic nuclei are closely related to motor activities in adult mice2013

    • Author(s)
      辰巳晃子
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibition of astrocyte metabolisms in the basal ganglionic nuclei lowers voluntary motor activities in adult mice.2013

    • Author(s)
      辰巳晃子、奥田洋明、森田晶子、山野眞理子、和中明生
    • Organizer
      第118回日本解剖学会総会
    • Place of Presentation
      かがわ国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Astrocytic morphologies in the basal ganglionic nuclei are closely related to motor activities in adult mice.2013

    • Author(s)
      辰巳晃子、奥田洋明、森田晶子、和中明生
    • Organizer
      Neuro2013(第36回日本神経科学大会・56回日本神経化学会大会・第23回日本神経回路学会大会 合同)
    • Place of Presentation
      京都国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Voluntary exercise promotes astrogliogenesis from Olig2 cells in some nuclei of the basal ganglia of adult mouse2012

    • Author(s)
      辰巳晃子
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      山梨大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Voluntary exercise promotes astrogliogenesis from Olig2 cells in the subthalamic nucleus of adult mouse2011

    • Author(s)
      辰巳晃子
    • Organizer
      第116回日本解剖学会総会第88回日本生理学会合同(震災により誌上開催)
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Voluntary exercise promotes astrogliogenesis from Olig2 cells in some nuclei of the basal ganglia of adult mouse2011

    • Author(s)
      辰巳晃子
    • Organizer
      第54回日本神経化学会
    • Place of Presentation
      加賀山代
    • Related Report
      2013 Final Research Report
  • [Presentation] Voluntary exercise promotes astrogliogenesis from Olig2 cells in some nuclei of the basal ganglia of adult mouse2011

    • Author(s)
      Kouko Tatsumi, Hiroaki Okuda, Mariko Yamano, Akio Wanaka
    • Organizer
      第54回日本神経化学会
    • Place of Presentation
      石川
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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