| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Abnormal protein accumulation is thought to be the cause of neuronal cell death at least in some neurodegenerative diseases. We hypothesized that ER stress-autophasy systems might be included in this disease mechanisms and the pivotal pathological structure is granulovacuolar degeneration. To study this hypothesis we carried out immunohistological examinations using postmortem brains.
In brains of multiple system atrophy, we observed increased expression of ER stress related proteins in granulovacuolar degeneration and also increased activation of lysosomal systems in microglia. In Alzheimer's brains, increased expression of a ubiquitin degradation system protein, called Smurf1 was detected in Hirano bodies.
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