Roles of granulovacuolar degeneration in neurodegenerative diseases
| Project/Area Number |
23500426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kouichi 群馬大学, その他部局等, 名誉教授 (00124652)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 顆粒空胞変性 / 神経変性疾患 / 平野小体 / オートファジー / 顆粒空砲変性 / 神経細胞死 |
|---|
| Research Abstract |
Abnormal protein accumulation is thought to be the cause of neuronal cell death at least in some neurodegenerative diseases. We hypothesized that ER stress-autophasy systems might be included in this disease mechanisms and the pivotal pathological structure is granulovacuolar degeneration. To study this hypothesis we carried out immunohistological examinations using postmortem brains.
In brains of multiple system atrophy, we observed increased expression of ER stress related proteins in granulovacuolar degeneration and also increased activation of lysosomal systems in microglia. In Alzheimer's brains, increased expression of a ubiquitin degradation system protein, called Smurf1 was detected in Hirano bodies.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Cerebrospinal fluid levels of phosphorylated tau and Aβ1-38/Aβ1-40/Aβ1-42 in Alzheimer's disease with PS1 mutations.2013
Author(s)
Ikeda M, Yonemura K, Kakuda S, Tashiro Y, Fujita Y, Takai E, Hashimoto Y, Makioka K, Furuta N, Ishiguro K, Maruki R, Yoshida J, Miyaguchi O, Tsukie T, Kuwano R, Yamazaki T, Yamaguchi H, Amari M, Takatama M, Harigaya Y, Okamoto K
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Journal Title
Amyloid
Volume: 20
Issue: 2
Pages: 107-712
DOI
Related Report
Peer Reviewed
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[Journal Article] fox-pigeon imitation test (YFPIT) for dementia in clinical practice2011
Author(s)
Yamaguchi H, Takahashi S, Kosaka K, Okamoto K, Yamazaki T, Ikeda M, Osawa M, Amari M, Harigaya Y, Awata S, Maki Y, Yamaguchi
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Journal Title
Psychogeriatrics
Volume: Vol.11
Issue: 4
Pages: 221-226
DOI
Related Report
Peer Reviewed
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