Functional screening and study of genes based on aggressive behavior, which is involved in autism and human developmental disorders.

• Project/Area Number: 23500427
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kanazawa University
• Principal Investigator: KOIZUMI Keita 金沢大学, 子どものこころの発達研究センター, 特任准教授 (70377406)
• Co-Investigator(Renkei-kenkyūsha): MUNESUE Toshio 金沢大学, 子どものこころの発達研究センター, 特任教授 (50293353) ; HIGASHIDA Haruhiro 金沢大学, 子どものこころの発達研究センター, 特任教授 (30093066) ; NAKAJIMA Hideo 熊本大学, エイズ学研究センター, 研究員 (00333394)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 攻撃衝動 / ストレスホルモン / 発達障害 / 自閉症 / 遺伝子 / ストレス / 脳発達障害 / 神経発生 / 自閉症／広汎性発達障害

Research Abstract

Starting from Drosophila genetic screening based on aggressive behavior, we aim to identify and study genes involved in human developmental disorders and psychiatric disorders such as depression. In this 3 years project, we finally reach 3 candidates, Robo2, Ect2 and Fam107B (we call it as "Hit") that is related to autism, mental retardation and depression.
One of them, Robo2 shows decreased expression in autistic human postmortem brain. Another gene, Hit responsible to stress hormone and related to function of Sgk1, a risk factor gene that may cause depression.

Research Products

• [Journal Article] Family with sequence similarity 107: A family of stress responsive small proteins with diverse functions in cancer and the nervous system . (2014)
  • Author(s): Nakajima H, Koizumi K.
  • Journal Title: Biomed Rep Volume: 2 Issue: 3 Pages: 321-325
  • DOI: 10.3892/br.2014.243
  • Peer Reviewed
• [Journal Article] Serotonin induces the migration of PC12 cells via the serotonin receptor 6/cAMP/ERK pathway. (2014)
  • Author(s): Nakajima H, Koizumi K.
  • Journal Title: Biomed Rep Volume: 2 Issue: 1 Pages: 29-33
  • DOI: 10.3892/br.2013.203
  • Peer Reviewed
• [Journal Article] Loss of HITS (FAM107B) expression in cancers of multiple organs : tissue microarray analysis (2012)
  • Author(s): Nakajima H, Koizumi K, Tanaka T, Ishigaki Y, Yoshitake Y, Yonekura H, Sakuma T, Fukushima T, Umehara H, Ueno S, Minamoto T and Motoo Y
  • Journal Title: International journal of oncology Volume: 41 Issue: 4 Pages: 1347-1357
  • DOI: 10.3892/ijo.2012.1550
  • Peer Reviewed
• [Journal Article] The cis-regulatory dynamics of the Drosophila CNS determinant castor are controlled by multiple sub-pattern enhancers (2012)
  • Author(s): Kuzin A, Kundu M, Ross J, Koizumi K, Brody T, Odenwald WF
  • Journal Title: Gene Expr Patterns Volume: 12 Issue: 7-8 Pages: 261-72
  • DOI: 10.1016/j.gep.2012.05.004
  • Peer Reviewed
• [Journal Article] Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism (2011)
  • Author(s): Suda S, Koizumi K , Higashida H, Mori N
  • Journal Title: Mol Autism Volume: 2 Issue: 1 Pages: 14-14
  • DOI: 10.1186/2040-2392-2-14
  • Peer Reviewed
• [Journal Article] Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma x glioma hybrid NG108-15 cells (2011)
  • Author(s): Tsuji T, Higashida C, Yoshida Y, Islam MS, Dohmoto M, Koizumi K, Higashida H
  • Journal Title: Cell Mol Neurobiol Volume: 31 Issue: 5 Pages: 663-8
  • DOI: 10.1007/s10571-011-9668-3
  • Peer Reviewed
• [Presentation] Study of FAM107A/B, new candidate genes critical for human developmental disorders (2013)
  • Author(s): Koizumi K, Nakao K, Nakajima H
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド, 神戸
  • Year and Date: 2013-12-02
• [Presentation] Study of new candidate genes that may have critical role for autism and also schizophrenia (2013)
  • Author(s): Koizumi K, Ito M, Nakao K, NakajimaH
  • Organizer: Neuroscience Meeting
  • Place of Presentation: Convention Center, Sandiego, USA
  • Year and Date: 2013-11-12
• [Presentation] Study of new candidate genes critical for human developmental disorders (2013)
  • Author(s): Koizumi K, Nakao K, Nakajima H
  • Organizer: 第56回日本神経化学会大会
  • Place of Presentation: 国立京都国際会館, 京都
  • Year and Date: 2013-06-21
• [Presentation] Study of new candidate genes critical for human developmental disorders. (2013)
  • Author(s): Koizumi K, Nakao K, Nakajima H.
  • Organizer: 第５６回 日本神経化学会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] Study of FAM107A/B, new candidate genes critical for human developmental disorders. (2013)
  • Author(s): Koizumi K, Nakao K, Nakajima H.
  • Organizer: 第３６回 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド、神戸
• [Presentation] Study of new candidate genes that may have critical role for autism and also schizophrenia. (2013)
  • Author(s): Koizumi K, ito M, Nakao K, Nakajima H.
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diedo, USA
• [Presentation] 脳発達障害に関わることが期待される新規遺伝子の解析 (2013)
  • Author(s): 小泉惠太、中尾啓子、中島日出夫
  • Organizer: Neuro2013、第56回日本神経化学会大会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] 自閉症, 精神遅滞などの発達障害に関わることが期待される新規遺伝子 (2012)
  • Author(s): 小泉惠太, 東田陽博, 中島日出夫
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡, マリンメッッセ福岡
  • Year and Date: 2012-12-11
• [Presentation] HITS (FAM107B) : Novel heat-shock induced protein involved in cancer progression and neurogenesis (2012)
  • Author(s): Nakajima H, Koizumi K
  • Organizer: 18th World Congress on Advances in Oncology
  • Place of Presentation: Hotel Creta Maris Resort, Greek
• [Presentation] 自閉症、精神遅滞などの発達障害に関わることが期待される新規遺伝子 (2012)
  • Author(s): 小泉惠太、東田陽博、中島日出夫
  • Organizer: 第35回 日本分子生物学会年会
  • Place of Presentation: マリンメッッセ福岡、福岡
• [Presentation] HITS (FAM107B): Novel heat-shock induced protein involved in cancer progression and neurogenesis. (2012)
  • Author(s): Nakajima H, Koizumi K
  • Organizer: 18th World Congress on Advances in Oncology
  • Place of Presentation: Creta Maris Resort, Greek
• [Presentation] Fly/mouse studies identify genes that have important role to cause human developmental disorders including mental retardation and autism (2011)
  • Author(s): Koizumi K, Nakajima H, Higashida H
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2011-12-14
• [Presentation] Fly/Mouse studies identify genes that have important role to cause human developmental disorders such as mental retardation and autism. (2011)
  • Author(s): 小泉惠太、中島日出夫、東田陽博
  • Organizer: 第34回 日本分子生物学会
  • Place of Presentation: 神奈川県パシフィコ横浜
• [Book] "Autism-A Neurodevelopmental Journey from Genes to Behaviour" (Chapter 10) (2011)
  • Author(s): Higashida H, Munesue T, Yokoyama S, Hashii M, Koizumi K. and Matsushima A(Edited by: Eapen V)
  • Total Pages: 485
  • Publisher: In Tech
• [Book] Autism - A Neurodevelopmental Journey from Genes to Behaviour. (2011)
  • Author(s): Higashida H., Munesue T., Yokoyama S., Hashii M., Koizumi K. and Matsushima A (Chpter 10), Edited by Eapen, V.
  • Total Pages: 484
  • Publisher: In Tech