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Comprehensive study on dystonia pathology

Research Project

Project/Area Number 23500428
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionThe University of Tokushima

Principal Investigator

GOTO Satoshi  徳島大学, ヘルスバイオサイエンス研究部, 特任教授 (50240916)

Co-Investigator(Kenkyū-buntansha) KAJI Ryuji  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00214304)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsジストニア / 神経病理 / 機能解剖 / 線条体 / パーキンソニズム / ストリオゾーム / 臨床神経生理 / 脳内機能マッピング / 遺伝子改変モデル / フィリピン / 脳深部刺激 / 大脳基底核 / 定位脳手術 / DBS
Research Abstract

In the mammalian striatum, there exist two functional subdivisions termed as striosome and matrix compartments. We have proposed a hypothesis that an imbalanced activities between the striosome and matrix compartments may cause movement disorders that include dystonia. During the last 3 years, we found a selective loss of dopamine D1 receptor D1R and Golf expression in the striosomes in a transgenic mouse model with dystonia, and suggest that a loss of D1Rmediated signaling in the striosomes may cause dystonia symptoms. Moreover, our pathological study on the autopsied brains showed the defects in the neuropeptide NPY system in the striatum of the patients with DYT3 dystonia. Since NPY has a protective role against glutamate receptor-mediated neurotoxicity and promotes striatal neurogenesis, this finding suggests that defects in the NPY system may underlie the genesis of progressive striatal generation that primarily occurs in the striosome compartment.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (47 results)

All 2014 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 1 results) Book (19 results)

  • [Journal Article] A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson's disease.2014

    • Author(s)
      Tanabe A, Yamamura Y, Kasahara J, Morigaki R, Kaji R, Goto S.
    • Journal Title

      Front Cell Neurosci

      Volume: 8 Pages: 1-11

    • DOI

      10.3389/fncel.2014.00050

    • NAID

      120006825959

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Defects in the striatal neuropeptide Y system in X-limked dystonia-parkinsonism.2013

    • Author(s)
      Goto S, et al
    • Journal Title

      Brain

      Volume: 136 Issue: 5 Pages: 1555-1567

    • DOI

      10.1093/brain/awt084

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Depression in X-linked dystonia-parkinsonism: a case-control study.2013

    • Author(s)
      Morigaki R, Nakataki M, Kawarai T, Lee LV, Teleg RA, Tabuena MD, Mure H, Sako W, Pasco PM, Nagahiro S, Iga J, Ohmori T, Goto S, Kaji R.
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 19 Issue: 9 Pages: 844-846

    • DOI

      10.1016/j.parkreldis.2013.04.027

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of long-range polymerase chain reaction in the diagnosis of X-linked dystonia-parkinsonism.2013

    • Author(s)
      Kawarai T, Pasco PM, Teleg RA, Kamada M, Sakai W, Shimozono K, Mizuguchi M, Tabuena D, Orlacchio A, Izumi Y, Goto S, Lee LV, Kaji R.
    • Journal Title

      Neurogenetics

      Volume: 14 Issue: 2 Pages: 167-169

    • DOI

      10.1007/s10048-013-0357-x

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role.2013

    • Author(s)
      Koizumi H, Morigaki R, Okita S, Nagahiro S, Kaji R, Nakagawa M, Goto S.
    • Journal Title

      Front Cell Neurosci

      Volume: 7 Pages: 1-12

    • DOI

      10.3389/fncel.2013.00074

    • NAID

      120006825960

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.2013

    • Author(s)
      Yamamura Y, et al
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 7 Pages: 1-12

    • DOI

      10.3389/fncel.2013.00012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Behavioural and anatomical characterization of mutant mice with targeted deletion of D1 dopamine-receptor-expressing cells : response to acute morphine2013

    • Author(s)
      D. Babovic, L. Jiang, S. Goto, I. Gantois, G , Schutz, A.J. Lawrence, J.L. Waddington & J. Drago
    • Journal Title

      J Pharmacol Sci

      Volume: 121 Pages: 39-47

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parkin interacts with Klokinl for mitochondrial import and maintenance of membrane potential2012

    • Author(s)
      Kuroda Y
    • Journal Title

      Human Molecular Genetics

      Volume: Vol.21 Issue: 5 Pages: 991-1003

    • DOI

      10.1093/hmg/ddr530

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cell type-specific localization of optineurin in the striatal neurons of mice : implications for neuronal vulnerability in Huntington' s disease2012

    • Author(s)
      S. Okita, R. Morigaki, H. Koizumi, R. Kaji, S. Nagahiro & S. Goto
    • Journal Title

      Neuroscience

      Volume: 202 Pages: 363-370

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.2012

    • Author(s)
      Ishiura H
    • Journal Title

      Am J Hum Genet.

      Volume: 91(2) Issue: 2 Pages: 320-9

    • DOI

      10.1016/j.ajhg.2012.07.014

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generalized dystonia in a patient with a novel mutation in the GLUD1 gene.2012

    • Author(s)
      Miyamoto R, et al.
    • Journal Title

      Movement Disorders

      Volume: 27 Issue: 9 Pages: 1198-1199

    • DOI

      10.1002/mds.25081

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cell type-specific localization of optineurin in the striatal neurons of mice: implications for neuronal vulnerability in Huntington's disease.2012

    • Author(s)
      Okita S, et al
    • Journal Title

      Neuroscience

      Volume: 202 Pages: 363-370

    • DOI

      10.1016/j.neuroscience.2011.11.059

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Practical management of botulinum toxin therapy2011

    • Author(s)
      Lim EC, Bhidayasiri R, Rosales RL, Kaji R.
    • Journal Title

      Introduction. Parkinsonism & related disorders

      Volume: 17 Issue: 2 Pages: 123-5

    • DOI

      10.1016/j.parkreldis.2010.11.013

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification and localization of a neuron-specific isoform of TAF1 in rat brain : implications for neuropathology of DYT3 dystonia2011

    • Author(s)
      Sako W, Morigaki R, Kaji R, et al.
    • Journal Title

      Neuroscience

      Volume: 189 Pages: 100-107

    • DOI

      10.1016/j.neuroscience.2011.05.031

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase 5 with phosphorylation of tyrosine 15 residue is enriched in striatal matrix compartment in adult mice2011

    • Author(s)
      R. Morigaki, W. Sako, S. Okita, J. Kasahara, H. Yokoyama, S. Ngahiro, R. Kaji & S. Goto
    • Journal Title

      Neuroscience

      Volume: 189 Pages: 25-31

    • DOI

      10.1016/j.neuroscience.2011.05.055

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brainstem and spinal cord motor neuron involvement with optineurin inclusions in proximal-dominant hereditary motor and sensory neuropathy2011

    • Author(s)
      Fujita K, Yoshida M, Sako W, et al
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82 Issue: 12 Pages: 1402-1403

    • DOI

      10.1136/jnnp-2011-300783

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brainstem and spinal cord motor neuron involvement with optineurin inclusions in proximal-dominant hereditary motor and sensory neuropathy.2011

    • Author(s)
      Koji Fujita,
    • Journal Title

      Journal of Neurology, Neurosurgery and Psychiatry

      Volume: 82 Pages: 1402-1403

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ジストニックストームにおける治療法の検討-4 例の自験例と文献的考察-2014

    • Author(s)
      牟礼英生, 小泉英貴, 森垣龍馬, 大北真哉, 梶龍兒, 永廣信治, 後藤恵
    • Organizer
      第53回日本定位・機能神経外科学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-02-08
    • Related Report
      2013 Final Research Report
  • [Presentation] X-linked dystonia-parkinsonism のニューロペプタイドY システム2014

    • Author(s)
      森垣龍馬, 瓦井俊孝, 小泉英貴, 牟礼英生, 大北真哉, 溝渕佳史, 永廣信治, 梶龍兒, 後藤惠
    • Organizer
      第53回日本定位・機能神経外科学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-02-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 高インスリン血性高アンモニア血性症候群に合併した全身性ジストニアに対し脳深部刺激術を施行した1例2014

    • Author(s)
      大北真哉, 森垣龍馬, 牟礼英生, 宮本亮介, 山本伸昭, 溝渕佳史, 後藤惠, 梶龍治, 永廣信治
    • Organizer
      第53回日本定位・機能神経外科学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-02-07
    • Related Report
      2013 Final Research Report
  • [Presentation] ドパミンシグナルはマウス線条体サイクリン依存性キナーゼ5(Cdk5)のチロシン15 残基リン酸化を抑制的に制御する2013

    • Author(s)
      山村行生, 森垣龍馬, 笠原二郎, 横山宏典, 田邊彬恵, 大北真哉, 小泉英貴, 永廣信治, 梶龍兒, 後藤惠
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場(京都府)
    • Related Report
      2013 Final Research Report
  • [Presentation] TFG 変異による運動ニューロン死のメカニズム2013

    • Author(s)
      瓦井俊孝, 森田光哉, 森垣龍馬, 藤田浩司, 野寺裕之, 和泉唯信, 後藤惠, 中野今治, 梶龍兒
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Final Research Report
  • [Presentation] ジストニアの病態生理 : 大脳基底核機能解剖2013

    • Author(s)
      後藤 惠
    • Organizer
      第54回日本神経学会学術大会シンポジウム S(4)-7 不随意運動の病態生理
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Final Research Report
  • [Presentation] ジストニアの病態生理:大脳基底核機能解剖2013

    • Author(s)
      後藤 惠
    • Organizer
      第54回日本神経学会学術大会シンポジウム
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] TFG変異による運動ニューロン死のメカニズム.2013

    • Author(s)
      瓦井俊孝, 森田光哉, 森垣龍馬, 藤田浩司, 野寺裕之, 和泉唯信, 後藤惠, 中野今治, 梶龍兒.
    • Organizer
      第54回日本神経学会学術大会シンポジウム
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ドパミンシグナルはマウス線条体サイクリン依存性キナーゼ5(Cdk5)のチロシン15残基リン酸化を抑制的に制御する.2013

    • Author(s)
      山村行生, 森垣龍馬, 笠原二郎, 横山宏典, 田邊彬恵, 大北真哉, 小泉英貴, 永廣信治, 梶龍兒, 後藤惠.
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] X-linked dystonia-parkinsonismのうつ症状。2013

    • Author(s)
      森垣龍馬、他
    • Organizer
      日本定位・機能神経外科学会
    • Place of Presentation
      岡山コンベンションセンター (岡山)
    • Related Report
      2012 Research-status Report
  • [Presentation] GPi-DBSを施行したX-linked dystonia-parkinsonism

    • Author(s)
      森垣龍馬
    • Organizer
      日本定位・機能神経外科学会
    • Place of Presentation
      東京(東京ステーションカンファランス)
    • Related Report
      2011 Research-status Report
  • [Book] Deep brain stimulation for essential tremor. In : T. Itakura (ed.) Deep Brain Stimulation for Neurological Disorder-Theoretical Background and Clinical Application2014

    • Author(s)
      R. Morigaki & S. Goto
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Book] Current use of thalamic Vim stimulation in treating Parkinson's disease. In : A.Q. Rana (ed.). Parkinson's Disease2014

    • Author(s)
      N. Tani, R. Morigaki, R. Kaji & S. Goto
    • Publisher
      InTech Publisher
    • Related Report
      2013 Final Research Report
  • [Book] Deep brain stimulation for camptocormia associated with Parkinson's disease. In : A.Q. Rana (ed.). Parkinson's Disease2014

    • Author(s)
      N. Tani, R. Kaji & S. Goto
    • Publisher
      InTech Publisher
    • Related Report
      2013 Final Research Report
  • [Book] DYT3 ジストニア (X-limked dystonia-parkinsonism : XDP, Lubag 症候群). 神経症候群II2014

    • Author(s)
      後藤 惠
    • Publisher
      日本臨床, 東京
    • Related Report
      2013 Final Research Report
  • [Book] A Synopsis of Parkinson's Disease,2014

    • Author(s)
      N. Tani, R. Morigaki, R. Kaji & S. Goto:
    • Total Pages
      20
    • Publisher
      InTech
    • Related Report
      2013 Annual Research Report
  • [Book] A Synopsis of Parkinson's Disease2014

    • Author(s)
      N. Tani, R. Kaji & S. Goto
    • Total Pages
      15
    • Publisher
      InTech
    • Related Report
      2013 Annual Research Report
  • [Book] Deep Brain Stimulation for Neurological Disorder-Theoretical Background and Clinical Application.2014

    • Author(s)
      R. Morigaki & S. Goto
    • Total Pages
      10
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] ジストニアの病理・機能解剖. ジストニアのすべて2013

    • Author(s)
      後藤 惠
    • Publisher
      診断と治療社, 東京
    • Related Report
      2013 Final Research Report
  • [Book] ジストニアのすべて2013

    • Author(s)
      後藤 惠
    • Total Pages
      9
    • Publisher
      診断と治療社
    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Book] 神経症候群II2013

    • Author(s)
      後藤 惠
    • Total Pages
      5
    • Publisher
      日本臨床
    • Related Report
      2013 Annual Research Report
  • [Book] ジストニアの分子病態- X-linked recessive dystonia-parkinsonism (XDP)を中心として. ジストニア20122012

    • Author(s)
      梶 龍兒, 後藤 惠 (他5名)
    • Publisher
      中外医学社, 東京
    • Related Report
      2013 Final Research Report
  • [Book] 不随意運動の診断と治療2012

    • Author(s)
      後藤 惠
    • Total Pages
      263
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] ジストニア20122012

    • Author(s)
      梶龍兒、他
    • Total Pages
      297
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] Current use of thalamic surgeries for treating movement disorders. In : J.L. Song et al. (eds.). Thalamus : Anatomy, Functions and Disorders2011

    • Author(s)
      R. Morigaki, S. Nagahiro, R. Kaji & S. Goto
    • Publisher
      Nova Science Publishers, New York
    • Related Report
      2013 Final Research Report
  • [Book] Thalamic deep brain stimulation for Parkinson's disease. In : A.Q. Rana (ed.). Diagnosis and treatment of Parkinson's disease2011

    • Author(s)
      R. Morigaki, S. Nagahiro, R. Kaji & S. Goto
    • Publisher
      InTech Publisher, Croatia
    • Related Report
      2013 Final Research Report
  • [Book] パーキンソン病のDBS治療2011

    • Author(s)
      後藤 惠
    • Publisher
      総合臨床
    • Related Report
      2013 Final Research Report
  • [Book] Thalamus: Anatomy, Functions and Disorders.2011

    • Author(s)
      Ryoma Morigaki,
    • Total Pages
      31
    • Publisher
      Nova Science Publishers
    • Related Report
      2011 Research-status Report
  • [Book] Parkinson's Disease.2011

    • Author(s)
      Ryoma Morigaki,
    • Total Pages
      19
    • Publisher
      InTech Publishers
    • Related Report
      2011 Research-status Report
  • [Book] パーキンソン病のDBS治療2011

    • Author(s)
      後藤恵
    • Total Pages
      6
    • Publisher
      長井書店
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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