• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on cellular diversity and treatment-sensitive/resistant fraction in IDH1-mutant gliomas

Research Project

Project/Area Number 23500429
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyushu University

Principal Investigator

SATOSHI Suzuki  九州大学, 医学(系)研究科(研究院), 准教授 (90294917)

Co-Investigator(Renkei-kenkyūsha) IWAKI Toru  九州大学, 大学院・医学研究院神経病理学 (40221098)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳腫瘍 / グリオーマ / イソクエン酸脱水素酵素1 / 免疫組織化学 / glioma / astrocytoma / oligodendroglioma / glioblastoma / IDH1 / immunohistochemistry
Research Abstract

To evaluate heterogeneity among cells in glioma tissues, we performed immunohistochemistry against mutant isocitrate dehydrogenase 1, a marker for a representative gene alteration in gliomas, together with other glioma markers (MAP-2e, p53, DCX, nestin), a proliferation marker (Ki-67) and lineage-specific markers (GFAP, Olig2, Iba-1). The results suggest existence of different tumor cell components with different genetic backgrounds and/or reactive components with a similar biological behavior to tumor cells even in one same tumor tissue. The findings would lead to the identification of tumor initiating cells, potentially a genuine therapeutic target, in tissue sections.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (12 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades.2014

    • Author(s)
      Togao O, Yoshiura T, Keupp J, Hiwatashi A, Yamashita K, Kikuchi K, Suzuki Y, Suzuki SO, Iwaki T, Hata N, Mizoguchi M, Yoshimoto K, Sagiyama K, Takahashi M, Honda H.
    • Journal Title

      Neuro Oncol

      Volume: 16 Issue: 3 Pages: 441-448

    • DOI

      10.1093/neuonc/not158

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced spinal cord glioblastoma with cerebrospinal fluid dissemination subsequent to treatment of lymphoblastic lymphoma.2013

    • Author(s)
      Kikkawa Y, Suzuki SO, Nakamizo A, Tsuchimochi R, Murakami N, Yoshitake T, Aishima S, Okubo F, Hata N, Amano T, Yoshimoto K, Mizoguchi M, Iwaki T, Sasaki T.
    • Journal Title

      Surg Neurol Int.

      Volume: 未定 Issue: 1 Pages: 27-27

    • DOI

      10.4103/2152-7806.107905

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pediatric glioblastoma with oligodendroglioma component: Aggressive clinical phenotype with distinct molecular characteristics.2013

    • Author(s)
      Mizoguchi M, Hata N, Suzuki SO, Fujioka Y, Murata H, Amano T, Nakamizo A, Yoshimoto K, Iwaki T, Sasaki T.
    • Journal Title

      Neuropathology

      Volume: 未定 Issue: 6 Pages: 652-7

    • DOI

      10.1111/neup.12029

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differentiating primary CNS lymphoma from glioblastoma multiforme : assessment using arterial spin labeling, diffusion-weightedimaging, and 18F-fluorodeoxyglucose positron emission tomography2013

    • Author(s)
      Yamashita K, Yoshiura T, Hiwatashi A, et al
    • Journal Title

      Neuroradiology

      Volume: 55(2) Issue: 2 Pages: 135-43

    • DOI

      10.1007/s00234-012-1089-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibrotic nodule arising from the cerebellopontine angle2013

    • Author(s)
      Amano T, Suzuki SO, Mizoguchi M, et al
    • Journal Title

      Brain Tumor Pathol

      Volume: 30(2) Issue: 2 Pages: 122-7

    • DOI

      10.1007/s10014-012-0105-1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer susceptibility and embryonic lethality in Mobla/lb double-mutant mice.2012

    • Author(s)
      Nishio M.
    • Journal Title

      J Clin Invest.

      Volume: 122 Issue: 12 Pages: 4505-4518

    • DOI

      10.1172/jci63735

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spinal endodermal cyst resembling an arachnoid cyst in appearance : Pitfalls in intraoperative diagnosis of cystic lesions2012

    • Author(s)
      Kikkawa Y, Nakamizo A, Suzuki SO, et al
    • Journal Title

      Surg Neurol Int

      Volume: 3 Issue: 1 Pages: 78-78

    • DOI

      10.4103/2152-7806.98518

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors2012

    • Author(s)
      Horiguchi M, et al
    • Journal Title

      Cancer Research

      Volume: 72(2) Issue: 2 Pages: 395-401

    • DOI

      10.1158/0008-5472.can-11-1891

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arterial spin labeling of hemangioblastoma : differentiation from metastatic brain tumors based on quantitative blood flow measurement2012

    • Author(s)
      Yamashita K, Yoshiura T, Hiwatashi A, et al
    • Journal Title

      Neuroradiology

      Volume: 54(8) Issue: 8 Pages: 809-13

    • DOI

      10.1007/s00234-011-0977-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent spinal nerve root schwannoma and meningioma mimicking single-component schwannoma2012

    • Author(s)
      Nakamizo A, Suzuki SO, Shimogawa T, et al
    • Journal Title

      Neuropathology

      Volume: 32(2) Issue: 2 Pages: 190-5

    • DOI

      10.1111/j.1440-1789.2011.01239.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characteristics of glioblastoma with 1p/19q co-deletion2012

    • Author(s)
      Mizoguchi M, Yoshimoto K, Ma X, Guan Y, Hata N, Amano T, Nakamizo A, Suzuki SO, Iwaki T, Sasaki T
    • Journal Title

      Brain Tumor Pathol

      Volume: 29(3) Issue: 3 Pages: 148-53

    • DOI

      10.1007/s10014-012-0107-z

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 臨床病理検討会指定討論2014

    • Author(s)
      鈴木 諭
    • Organizer
      第32回日本脳腫瘍病理学会
    • Place of Presentation
      徳島
    • Related Report
      2013 Final Research Report
  • [Presentation] 教育セミナー「神経鞘腫および遺伝性腫瘍の病理」2014

    • Author(s)
      鈴木 諭
    • Organizer
      第32回日本脳腫瘍病理学会
    • Place of Presentation
      徳島
    • Related Report
      2013 Final Research Report
  • [Presentation] 臨床病理検討会指定討論2013

    • Author(s)
      鈴木 諭
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 教育セミナー「神経鞘腫および遺伝性腫瘍の病理」2013

    • Author(s)
      鈴木 諭
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 臨床病理検討会指定討論2012

    • Author(s)
      鈴木 諭
    • Organizer
      第30回日本脳腫瘍病理学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Hrm法によるIDH1 mutation解析2012

    • Author(s)
      秦暢宏、溝口昌弘、吉本幸司、村田秀樹、空閑太亮、鈴木諭、岩城徹、佐々木富男
    • Organizer
      第30回日本脳腫瘍病理学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] ニューロピルと真性ロゼットに富む胎児生腫瘍(ETANTR)の2例2012

    • Author(s)
      鈴木諭、久岡正典、秦暢宏、田中俊也、吉本幸司、溝口昌弘、若宮富浩、吉浦敬、佐々木富男、岩城徹
    • Organizer
      第30回日本脳腫瘍病理学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 線毛上皮を有する頭蓋咽頭腫症例の病理学的検討

    • Author(s)
      吉本幸司、溝口昌弘、鈴木諭、岩城徹、秦暢宏、佐々木富男
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] GliomaにおけるS100Pの免疫組織学的検討

    • Author(s)
      若宮富浩、鈴木諭、中原由起子、本田裕之、松島俊夫、岩城徹
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] High grade glioma診断における遺伝子解析の役割

    • Author(s)
      溝口昌弘、吉本幸司、秦暢宏、村田秀樹、波多江龍亮、天野敏之、中溝玲、鈴木諭、岩城徹,佐々木富男
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 教育セミナー「神経鞘腫および遺伝性腫瘍の病理」

    • Author(s)
      鈴木諭
    • Organizer
      第31回日本脳腫瘍病理学会」
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 臨床病理検討会指定討論

    • Author(s)
      鈴木諭
    • Organizer
      第31回日本脳腫瘍病理学会」
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 癌診療指針のための病理診断プラクティス「脳腫瘍」2012

    • Author(s)
      鈴木諭、岩城徹(青笹克之、中里洋一編集)
    • Total Pages
      348
    • Publisher
      中山書店
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi