Study on cellular diversity and treatment-sensitive/resistant fraction in IDH1-mutant gliomas
Project/Area Number |
23500429
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
|
Research Institution | Kyushu University |
Principal Investigator |
SATOSHI Suzuki 九州大学, 医学(系)研究科(研究院), 准教授 (90294917)
|
Co-Investigator(Renkei-kenkyūsha) |
IWAKI Toru 九州大学, 大学院・医学研究院神経病理学 (40221098)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 脳腫瘍 / グリオーマ / イソクエン酸脱水素酵素1 / 免疫組織化学 / glioma / astrocytoma / oligodendroglioma / glioblastoma / IDH1 / immunohistochemistry |
Research Abstract |
To evaluate heterogeneity among cells in glioma tissues, we performed immunohistochemistry against mutant isocitrate dehydrogenase 1, a marker for a representative gene alteration in gliomas, together with other glioma markers (MAP-2e, p53, DCX, nestin), a proliferation marker (Ki-67) and lineage-specific markers (GFAP, Olig2, Iba-1). The results suggest existence of different tumor cell components with different genetic backgrounds and/or reactive components with a similar biological behavior to tumor cells even in one same tumor tissue. The findings would lead to the identification of tumor initiating cells, potentially a genuine therapeutic target, in tissue sections.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades.2014
Author(s)
Togao O, Yoshiura T, Keupp J, Hiwatashi A, Yamashita K, Kikuchi K, Suzuki Y, Suzuki SO, Iwaki T, Hata N, Mizoguchi M, Yoshimoto K, Sagiyama K, Takahashi M, Honda H.
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Journal Title
Neuro Oncol
Volume: 16
Issue: 3
Pages: 441-448
DOI
Related Report
Peer Reviewed
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[Journal Article] Radiation-induced spinal cord glioblastoma with cerebrospinal fluid dissemination subsequent to treatment of lymphoblastic lymphoma.2013
Author(s)
Kikkawa Y, Suzuki SO, Nakamizo A, Tsuchimochi R, Murakami N, Yoshitake T, Aishima S, Okubo F, Hata N, Amano T, Yoshimoto K, Mizoguchi M, Iwaki T, Sasaki T.
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Journal Title
Surg Neurol Int.
Volume: 未定
Issue: 1
Pages: 27-27
DOI
Related Report
Peer Reviewed
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