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Analysis of pathophysiology of hereditary cerebral amyloid angiopathy associated with amyloidgenic transthyretin Y114C

Research Project

Project/Area Number 23500430
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKumamoto University

Principal Investigator

YAMASHITA Taro  熊本大学, 生命科学研究部, 講師 (90381003)

Co-Investigator(Kenkyū-buntansha) ANDO Yukio  熊本大学, 生命科学研究部・神経内科学分野, 教授 (20253742)
HIRAHARA Tomoo  熊本大学, 医学部附属病院・神経内科, 助教 (80649343)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脳アミロド血管症 / トランスサイレチン / 認知症 / 脳出血 / 脳血管透過性亢進 / 肝移植 / 治療 / 脳アミロイド血管症 / 血管透過性亢進 / 微小脳出血 / 脳血管炎 / アミロイド血管症
Research Abstract

Patients with amyloidogenic transthyretin (TTR) Y114C develop amyloid deposits in cerebral blood vessels, cerebral hemorrhage, and rapidly progressive dementia that presents with hereditary cerebral amyloid angiopathy (CAA). MRI studies with FLAIR images after Gd administration showed Gd leakage into the subarachnoid space. The pathogenesis of CNS disorders may reflect disruption of the blood-CSF barrier and blood-brain barrier by amyloid deposition. The mortality and occurrence of cerebral hemorrhage and dementia in patients having transplantations were reduced compared with those in patients not having transplantations. The group undergoing transplantations had significantly smaller volumes of intracranial hemorrhage than did the no-transplantation group. Liver transplantation was effective for CNS manifestations of cerebral amyloid angiopathy associated with amyloidogenic transthyretin Y114C.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (58 results)

All 2014 2013 2012 2011 Other

All Journal Article (24 results) (of which Peer Reviewed: 21 results) Presentation (32 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Gait Disturbance due to Foot Drop Is Refractory to Treatment in Nonsystemic Vasculitic Neuropathy2014

    • Author(s)
      Hirahara T, Yamashita S, Misumi Y, Kawakami K, Hori H, Honda S, Watanabe M, Ikeda T, Yamashita T, Maeda Y, Ando Y
    • Journal Title

      Eur Neurol

      Volume: 71 Issue: 3-4 Pages: 180-186

    • DOI

      10.1159/000355531

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] アミロイドニューロパチー2014

    • Author(s)
      山下太郎
    • Journal Title

      今日の治療指針

      Volume: - Pages: 886-887

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial2013

    • Author(s)
      Berk JL, Suhr OB, Obici L, Sekijima Y, Zeldenrust SR, Yamashita T, Heneghan MA, Gorevic PD, Litchy WJ, Wiesman JF, Nordh E, Corato M, Lozza A, Cortese A, Robinson-Papp J, Colton T, Rybin DV, Bisbee AB, Ando Y, Ikeda S, Seldin DC, Merlini G, Skinner M, Kelly JW, Dyck PJ; Diflunisal Trial Consortium
    • Journal Title

      JAMA

      Volume: 310 Issue: 24 Pages: 2658-2667

    • DOI

      10.1001/jama.2013.283815

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of age and sex differences on wild-type transthyretin amyloid formation in familial amyloidotic polyneuropathy: a proteomic approach2013

    • Author(s)
      Tasaki M, Ueda M, Obayashi K, Koike H, Kitagawa K, Ogi Y, Jono H, Su Y, Suenaga G, Oshima T, Misumi Y, Yoshida M, Yamashita T, Sobue G, Ando Y
    • Journal Title

      Int J Cardiol

      Volume: 170 Issue: 1 Pages: 69-74

    • DOI

      10.1016/j.ijcard.2013.10.033

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation2013

    • Author(s)
      Oshima T, Kawahara S, Ueda M, Kawakami Y, Tanaka R, Okazaki T, Misumi Y, Obayashi K, Yamashita T, Ohya Y, Ihse E, Shinriki S, Tasaki M, Jono H, Asonuma K, Inomata Y, Westermark P, Ando Y
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: - Issue: 7 Pages: 740-746

    • DOI

      10.1136/jnnp-2013-305973

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dominant cardiac type of familial amyloidotic polyneuropathy associated with a novel transthyretin variant Thr59Arg2013

    • Author(s)
      Obayashi K, Misumi Y, Watanabe T, Ando T, Akagami T, Tasaki M, Shinriki S, Ueda M, Yamashita T, Hirotani S, Ando Y
    • Journal Title

      Muscle Nerve

      Volume: 48(5) Issue: 5 Pages: 839-41

    • DOI

      10.1002/mus.23939

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Marked cardiomegaly in a patient with familial amyloidotic polyneuropathy after orthotopic liver transplantation: a case study2013

    • Author(s)
      Sakashita N, Kagawa S, Date R, Ueno T, Nakagawa T, Yamashita T, Obayashi K, Ohshima T, Ueda M, Horiguchi H, Ando Y, Takeya M
    • Journal Title

      Pathol Int

      Volume: 63 Issue: 5 Pages: 260-265

    • DOI

      10.1111/pin.12055

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amyloid fibrils containing fragmented ATTR may be the standard fibril composition in ATTR amyloidosis2013

    • Author(s)
      Ihse E, Rapezzi C, Merlini G, Benson MD, Ando Y, Suhr OB, Ikeda S, Lavatelli F, Obici L, Quarta CC, Leone O, Jono H, Ueda M, Lorenzini M, Liepnieks J, Ohshima T, Tasaki M, Yamashita T, Westermark P
    • Journal Title

      Amyloid

      Volume: 20(3) Issue: 3 Pages: 142-50

    • DOI

      10.3109/13506129.2013.797890

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine2013

    • Author(s)
      Obayashi K, Tasaki M, Jono H, Ueda M, Shinriki S, Misumi Y, Yamashita T, Oshima T, Nakamura T, Ikemizu S, Anan I, Suhr O, Ando Y
    • Journal Title

      Clin Chim Acta

      Volume: 419 Pages: 127-31

    • DOI

      10.1016/j.cca.2013.02.002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral basal ganglia lesions as initial manifestation of CNS invasion in adult T-cell leukemia2013

    • Author(s)
      Matsuo Y, Yamashita S, Honda S, Nakajima M, Ueda A, Hirahara T, Yamashita T, Maeda Y, Hirano T, Ando Y
    • Journal Title

      J Neurol Sci

      Volume: 327(1-2) Issue: 1-2 Pages: 63-4

    • DOI

      10.1016/j.jns.2013.01.035

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis2013

    • Author(s)
      Uchino M, Yamashita S, Uchino K, Mori A, Hara A, Suga T, Hirahara T, Koide T, Kimura E, Yamashita T, Ueda A, Kurisaki R, Suzuki J, Honda S, Maeda Y, Hirano T, Ando Y
    • Journal Title

      Clin Neurol Neurosurg

      Volume: 115(5) Issue: 5 Pages: 603-6

    • DOI

      10.1016/j.clineuro.2012.07.019

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] トランスサイレチンTyr114Cys型遺伝性脳アミロイド血管症の病態解析2013

    • Author(s)
      山下太郎
    • Journal Title

      熊本医学会ニュースレター

      Volume: 11 Pages: 12-14

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy2012

    • Author(s)
      Yamashita T, Ando Y, Okamoto S, Misumi Y, Hirahara T, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma K, Inomata Y, Uchino M
    • Journal Title

      Neurology

      Volume: 78(9) Issue: 9 Pages: 637-43

    • DOI

      10.1212/wnl.0b013e318248df18

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological changes long after liver transplantation in a familial amyloidotic polyneuropathy patient.2012

    • Author(s)
      Obayashi K, Ueda M, Yazaki M(8番目), et al.
    • Journal Title

      BMJ Case rep

      Volume: - Pages: bcr2012006593-bcr2012006593

    • DOI

      10.1136/bcr-2012-006593

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between amyloid deposition and intracellular structural changes in familial amyloidotic polyneuropathy2012

    • Author(s)
      Misumi Y, Ueda M, Obayashi K, Jono H, Su Y, Yamashita T, Ohshima T, Ando Y, Uchino M
    • Journal Title

      Hum Pathol

      Volume: 43(1) Issue: 1 Pages: 96-104

    • DOI

      10.1016/j.humpath.2011.01.036

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Diflunisal Trial: study accrual and drug tolerance.2012

    • Author(s)
      Berk JL, Suhr OB, Sekijima Y, Yamashita T, Heneghan M, Zeldenrust SR, Ando Y, Ikeda S, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Dyck PJ, Obici L
    • Journal Title

      Amyloid

      Volume: Suppl 1 Issue: sup1 Pages: 37-38

    • DOI

      10.3109/13506129.2012.678509

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 家族性アミロイドポリニューロパチーにおける臨床症候に対する肝移植の長期的効果の検討2012

    • Author(s)
      山下太郎,奥村幸祐,大嶋俊範,三隅洋平,植田明彦,菅智宏,神力悟,植田光晴,城野博史,大林光念,山下賢,前田寧,安東由喜雄.
    • Journal Title

      Peripheral Nerve

      Volume: 23 Pages: 256-257

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy2012

    • Author(s)
      Yamashita T, Ando Y, Okamoto S, Misumi Y, Hirahara T, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma K, Inomata Y, Uchino M.
    • Journal Title

      Neurology

      Volume: 78 Pages: 637-643

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of liver transplantation on the survival of patients with ordinary onset familial amyloid polyneuropathy in Japan2011

    • Author(s)
      Yamashita T, Ando Y, Okamoto S, Yohei M, Hitahara T, Ueda M, Obayashi K, Nakamura M, Jono H, Asonuma K, Inomata Y, Uchino M
    • Journal Title

      Amyloid

      Volume: Suppl1 Issue: sup1 Pages: 185-6

    • DOI

      10.3109/13506129.2011.574354069

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spinal multifocal amyloidosis derived from wild-type transthyretin2011

    • Author(s)
      Sueyoshi T, Ueda M, Sei A, Misumi Y, Oshima T, Yamashita T, Obayashi K, Shinriki S, Jono H, Shono M, Ando Y, Mizuta H
    • Journal Title

      Amyloid

      Volume: 8(3) Issue: 3 Pages: 165-8

    • DOI

      10.3109/13506129.2011.582197

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amyloid neuropathy in a younger domino liver transplanted recipient2011

    • Author(s)
      Obayashi K, Yamashita T, Tasaki M, Ueda M, Shono M, Jono H, Ohshima T, Ohya Y, Asonuma K, Inomata Y, Ando Y
    • Journal Title

      Muscle Nerve

      Volume: 3(3) Issue: 3 Pages: 449-50

    • DOI

      10.1002/mus.21941

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of liver transplantation on the survival of patients with ordinary onset familial amyloid polyneuropathy in Japan2011

    • Author(s)
      Yamashita T, Ando Y, Okamoto S, Yohei M, Hirahara T, Ueda M, Obayashi K, Nakamura M, Jono H, Asonuma K, Inomata Y, Uchino M
    • Journal Title

      Amyloid

      Volume: 18 Suppl 1 Pages: 180-181

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A homozygote case of familial amyloid polyneuropathy amyloidgenic transthyretin Val30Met in a non-endemic area2011

    • Author(s)
      Kumabe Y, Miura A, Yamashita T, Oshima T, Misumi Y, Ueda M, Obayashi K, Horibata Y, Jono H, Ando Y, Uchino M
    • Journal Title

      Amyloid

      Volume: 18 Suppl 1 Pages: 164-165

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 家族性アミロイドポリニューロパチー2011

    • Author(s)
      山下太郎, 安東由喜雄, 内野 誠
    • Journal Title

      Brain Nerve

      Volume: 63 Pages: 583-595

    • Related Report
      2011 Research-status Report
  • [Presentation] 装着型ロボットスーツによる神経難病患者における歩行障害改善効果の検討2014

    • Author(s)
      山下太郎, 阪本徹郎, 栗﨑玲一, 植川和利, 三隅洋平, 植田光晴, 平原智雄, 渡邉聖樹, 山下賢, 前田寧, 大林光念, 安東由喜雄
    • Organizer
      第19回国立病院機構熊本南病院開放型病院連絡会
    • Place of Presentation
      熊本, 松橋ホワイトパレス
    • Related Report
      2013 Annual Research Report
  • [Presentation] サイバニクスによる家族性アミロイドポリニューロパチー(FAP) 患者における運動障害改善効果の検討2013

    • Author(s)
      山下太郎, 中西俊人, 道鬼つかさ, 井上泰輝, 三隅洋平, 植田明彦, 植田光晴, 平原智雄, 渡邊聖樹, 山下賢, 前田寧, 大林光念, 安東由喜雄
    • Organizer
      第1回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Transthyretin Y114C-related Angitis in Cerebral Amyloid Angiopathy after Liver Transplantation2013

    • Author(s)
      Yamashita T, Ohnishi K, Okumura K, Oshima T, Inoue Y, Misumi Y, Suga T, Ueda A, Ueda M, Yamashita S, Maeda Y, Shinriki S, Obayashi K, Sakashita N, Takeya M, Ando Y
    • Organizer
      IXth International Symposium on Familial Amyloidotic Polyneuropathy (ISFAP) and the VIIIth International Symposium on Liver Transplantation in Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] An Autopsy Case of Transthyretin Y114C-related Cerebral Amyloid Angiopathy after Liver Transplantation2013

    • Author(s)
      Yamashita T, Koji Onishi, Kosuke Okumura, Toshinori Oshima, Yasuteru Inoue, Yohei Misumi, Tomohiro Suga, Akihiko Ueda, Mitsuharu Ueda, Satoshi Yamashita, Yasushi Maeda, Satoru Shinriki, Konen Obayashi, Naomi Sakashita, Motohiro Takeya, Ando Y
    • Organizer
      American Academy of Neurology 65th Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] ATTR Y114C 型脳アミロイド血管症剖検例における神経病理学的検討2013

    • Author(s)
      山下太郎, 大嶋俊範, 田崎雅義, 道鬼つかさ, 三隅洋平, 神力悟, 植田光晴, 城野博史, 大林光念, 山下賢, 前田寧, 安東由喜雄
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] FAP 患者肝を用いたドミノ移植患者剖検例におけるアミロイド沈着様式の検討2013

    • Author(s)
      山下太郎, 小池春樹, 大嶋俊範, 磯野香織, 田崎雅義, 三隅洋平, 植田光晴, 神力悟, 大林光念, 城野博史, 祖父江元, 安東由喜雄
    • Organizer
      平成24年度アミロイドーシスに関する調査研究班研究報告会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ATTR Y114C型脳アミロイド血管症剖検例における神経病理学的検討2013

    • Author(s)
      山下太郎, 大嶋俊範, 田崎雅義, 道鬼つかさ, 三隅洋平, 神力 悟,植田光晴,城野博史,大林光念, 山下賢, 前田寧, 安東由喜雄
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京, 東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] サイバニクスによる家族性アミロイドポリニューロパチー (FAP) 患者における運動障害改善効果の検討2013

    • Author(s)
      山下太郎, 中西俊人, 道鬼つかさ, 井上泰輝, 三隅洋平, 植田明彦, 植田光晴, 平原智雄, 渡邊聖樹, 山下 賢, 前田 寧, 大林光念, 安東由喜雄
    • Organizer
      第1回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京, KKRホテル東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] An Autopsy Case of Transthyretin Y114C-related Cerebral Amyloid Angiopathy after Liver Transplantation2013

    • Author(s)
      Yamashita T, Onishi K, Okumura K, Oshima T, Inoue Y, Misumi Y, Suga T, Ueda A, Ueda M, Yamashita S, Maeda M, Shinriki S, Obayashi K, Sakashita N, Takeya M, Ando Y
    • Organizer
      American Academy of Neurology 65th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] FAP患者肝を用いたドミノ移植患者剖検例におけるアミロイド沈着様式の検討2013

    • Author(s)
      山下太郎, 小池春樹, 大嶋俊範, 磯野香織, 田崎雅義, 三隅洋平, 植田光晴, 神力 悟,大林光念, 城野博史, 祖父江元, 安東由喜雄
    • Organizer
      平成24年度アミロイドーシスに関する調査研究班 研究報告会
    • Place of Presentation
      東京, KKRホテル東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Detection of Microbleeds in Hereditary Cerebral Amyloid Angiopathy Associated with Amyloidgenic Transthyretin Tyr114Cys Using Susceptibility-weighted Imaging2012

    • Author(s)
      Yamashita T, Hirano T, Hirai T, Oshima T, Okumura K, Tateishi M, Yohei M, Yamashita S, Maeda Y, Shinriki S, Ueda M, Obayashi K, Ando Y
    • Organizer
      XIII International Symposium on Amyloidosis
    • Place of Presentation
      Groningen, The Netherlands
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Early TTR-FAP patient identification and diagnosis - the example of Japan2012

    • Author(s)
      Yamashita T, Ando Y
    • Organizer
      TTR-FAP Global Commercial Advisory Board
    • Place of Presentation
      London, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] ATTR Y114C 型脳アミロイド血管症におけるアミロイド沈着の分布の解析2012

    • Author(s)
      山下太郎, 大嶋俊範, 奥村幸祐, 永利聡仁, 立石真知子, 三隅洋平, 神力 悟, 植田光晴, 大林光念, 城野博史, 安東由喜雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] トランスサイレチンY114C 型遺伝性脳アミロイド血管症患者における肝移植後の臨床症候の長期的変化2012

    • Author(s)
      奥村幸祐, 山下太郎, 立石真知子, 大嶋俊範, 植田明彦, 三隅洋平, 平原智雄, 本田省ニ, 植田光晴, 大林光念, 山下 賢, 前田 寧, 安東由喜雄
    • Organizer
      第30回日本神経治療学会総会
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーにおける臨床症候に対する肝移植の長期的効果の検討2012

    • Author(s)
      山下太郎, 奥村幸祐, 大嶋俊範, 三隅洋平, 植田明彦, 菅 智宏, 神力 悟, 植田光晴, 城野博史, 大林光念, 山下 賢, 前田 寧, 安東由喜雄
    • Organizer
      第23回日本末梢神経学会学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] Early TTR-FAP patient identification and diagnosis – the example of Japa2012

    • Author(s)
      Yamashita T, Ando Y
    • Organizer
      TTR-FAP Global Commercial Advisory Board
    • Place of Presentation
      London, UK
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ATTR Y114C型脳アミロイド血管症におけるアミロイド沈着の分布の解析2012

    • Author(s)
      山下太郎, 大嶋俊範, 奥村幸祐, 永利聡仁, 立石真知子, 三隅洋平, 神力 悟, 植田光晴, 大林光念, 城野博史, 安東由喜雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京, 東京国際フォーラム
    • Related Report
      2012 Research-status Report
  • [Presentation] トランスサイレチンY114C型遺伝性脳アミロイド血管症患者における肝移植後の臨床症候の長期的変化2012

    • Author(s)
      奥村幸祐,山下太郎,立石真知子,大嶋俊範,植田明彦,三隅洋平,平原智雄,本田省ニ,植田光晴,大林光念,山下 賢,前田 寧, 安東由喜雄
    • Organizer
      第30回日本神経治療学会総会
    • Place of Presentation
      北九州市, 北九州国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 家族性アミロイドポリニューロパチーにおける臨床症候に対する肝移植の長期的効果の検討2012

    • Author(s)
      山下太郎, 奥村幸祐,大嶋俊範,三隅洋平,植田明彦,菅 智宏, 神力 悟,植田光晴,城野博史,大林光念,山下 賢,前田 寧,安東由喜雄
    • Organizer
      第23回日本末梢神経学会学術集会
    • Place of Presentation
      福岡市, 九州大学医学部百年講堂
    • Related Report
      2012 Research-status Report
  • [Presentation] 脳血管髄膜型トランスサイレチンY114C関連アミロイドーシスにおける肝移植の効果と限界-V30M以外の病型で効果はあるのか-2012

    • Author(s)
      安東由喜雄, 山下太郎, 大嶋俊範, 田崎雅義, 三隅洋平, 神力 悟,植田光晴,城野博史,大林光念
    • Organizer
      難治性ニューロパチーの診断技術と治療法の開発に関する研究」班会議
    • Place of Presentation
      東京, 都市センターホテル
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of liver transplantation on clinical manifestations of familial amyloid polyneuropathy2011

    • Author(s)
      Yamashita T, Misumi Y, Okamoto S, Hitahara T, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma K, Inomata Y, Uchino M, Ando Y
    • Organizer
      2011 Biennial Meeting of the Peripheral Nerve Society
    • Place of Presentation
      Potomac, Maryland
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of Liver Transplantation on Peripheral Neuropathy of Familial Amyloid Polyneuropathy V30M2011

    • Author(s)
      Yamashita T, Oshima T, Okumur K, Nagatoshi A, Misumi M, Okamoto S, Ueda A, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma K, Ando Y, Inomata Y
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy and VIIth International Symposium on Liver Transplantation in Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] A Case of Familial Amyloidotic Polyneuropathy ATTR Ser77Tyr : The First Report from Japan2011

    • Author(s)
      Nagatoshi A, Yamashita T, Nagano H, Teramoto S, Okumura K, Oshima K, Misumi Y, Okamoto S, Ueda A, Ueda M, Obayashi K, Jono 2, Shono M, Ando Y
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy and VIIth International Symposium on Liver Transplantation in Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] Long-term Outcome of Clinical Manifestations after Liver Transplantation in Patients with Familial Amyloid Polyneuropathy Val30Met2011

    • Author(s)
      Okumura K, Yamashita T, Oshima T, Nagatoshi A, Misumi Y, Okamoto S, Ueda A, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma A, Inomata Y, Ando Y
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy and VIIth International Symposium on Liver Transplantation in Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] 家族性アミロイドポリニューロパチー患者の末梢神経障害に対する肝移植の効果の検討2011

    • Author(s)
      山下太郎, 三隅洋平, 大嶋俊範, 植田明彦, 植田光晴, 城野博史, 大林光念, 安東由喜雄, 内野 誠
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of liver transplantation on clinical manifestations of familial amyloid polyneuropathy2011

    • Author(s)
      Yamashita T, Misumi Y, Okamoto S, Hitahara T, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma K, Inomata Y, Uchino M, Ando Y
    • Organizer
      2011 Biennial Meeting of the Peripheral Nerve Society
    • Place of Presentation
      The Bolger Center, Potomac, Maryland
    • Related Report
      2011 Research-status Report
  • [Presentation] Effect of Liver Transplantation on Peripheral Neuropathy of Familial Amyloid Polyneuropathy V30M2011

    • Author(s)
      Yamashita T, Oshima T, Okumura K, Nagatoshi A, Misumi M, Okamoto S, Ueda A, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma K, Ando Y, Inomata Y
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy and VIIth International Symposium on Liver Transplantation in Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      熊本市医師会館, 熊本県熊本市
    • Related Report
      2011 Research-status Report
  • [Presentation] A Case of Familial Amyloidotic Polyneuropathy ATTR Ser77Tyr: The First Report from Japan2011

    • Author(s)
      Nagatoshi A, Yamashita T, Nagano H, Teramoto S, Okumura K, Oshima K, Misumi Y, Okamoto S, Ueda A, Ueda M, Obayashi K, Jono H, Shono M, Ando Y
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy and VIIth International Symposium on Liver Transplantation in Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      熊本市医師会館, 熊本県熊本市
    • Related Report
      2011 Research-status Report
  • [Presentation] Long-term Outcome of Clinical Manifestations after Liver Transplantation in Patients with Familial Amyloid Polyneuropathy Val30Met2011

    • Author(s)
      Okumura K, Yamashita T, Oshima T, Nagatoshi A, Misumi Y, Okamoto S, Ueda A, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma A, Inomata Y, Ando Y
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy and VIIth International Symposium on Liver Transplantation in Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      熊本市医師会館, 熊本県熊本市
    • Related Report
      2011 Research-status Report
  • [Presentation] 家族性アミロイドポリニューロパチー患者の末梢神経障害に対する肝移植の効果の検討2011

    • Author(s)
      山下太郎, 三隅洋平, 大嶋俊範, 植田明彦, 植田光晴, 城野博史, 大林光念, 安東由喜雄, 内野 誠
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場, 愛知県名古屋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 家族性アミロイドポリニューロパチー患者の末梢神経障害に対する肝移植の効果の検討:肝移植例と自然史との比較

    • Author(s)
      安東由喜雄, 山下太郎, 大嶋俊範, 奥村幸祐, 永利聡仁, 三隅洋平, 田崎雅, 神力 悟, 植田光晴, 大林光念, 庄野 信, 城野博史
    • Organizer
      難治性ニューロパチーの診断技術と治療法の開発に関する研究 班会議
    • Place of Presentation
      都市センターホテル, 東京都千代田区
    • Related Report
      2011 Research-status Report
  • [Presentation] SWI にて微小脳出血を認めたトランスサイレチンTyr114Cys型遺伝性脳アミロイド血管症の2例

    • Author(s)
      奥村幸祐,山下太郎,立石真知子,持永崇恵,三浦正智,大嶋俊範, 植田明彦,平原智雄,本田省二,山下賢,前田寧,平野照之,安東由喜雄
    • Organizer
      第197回日本神経学会九州地方会
    • Place of Presentation
      九州大学医学部百年講堂, 福岡県福岡市
    • Related Report
      2011 Research-status Report
  • [Remarks] 熊本大学大学院生命科学研究部神経内科学分野(ホームページ等)

    • URL

      http://www2.kuh.kumamoto-u.ac.jp/neurology/

    • Related Report
      2013 Final Research Report
  • [Remarks] 熊本大学医学部附属病院神経内科アミロイドーシス診療体制構築事業(ホームページ等)

    • URL

      http://www2.kuh.kumamoto-u.ac.jp/amyloidunit/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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