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Neuropathologic analysis of small vessel diseases of the cerebral white matter in association with sporadic and hereditary dementia

Research Project

Project/Area Number 23500435
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

TAKAO MASAKI  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50245487)

Co-Investigator(Kenkyū-buntansha) SAITO Yuko  独立行政法人国立精神・神経医療研究センター, 臨床検査部, 室長 (60344066)
Research Collaborator ITO S  虎ノ門病院, 病理, 医師
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脳・神経 / 病理学 / 脳血管疾患 / 認知症 / 神経科学 / 長寿命化 / 生体材料
Research Abstract

The aim of the present study is to clarify the role of small vessel diseases in the cerebral white matter in dementia individuals. We carried out clinical and neuropathologic studies of 1) CARASIL cases, 2) mildly demented (CDR=0.5) individuals and 3) morphological analysis of small vessels in the cerebral white matter and putamen. The small vessels of CARASIL showed multilayers of elastic membranes and thinning of tunica media. Those findings were different from those of usual atherosclerotic changes. Frequency of cerebrovascular diseases was relatively high in mildly demented cases. However, the rate of cerebrovascular diseases decreased with increase of age. The lumen of small vessels in the cerebral white matter decreased with increasing grade of Braak stages of neurofibrillary tangles. Our multidisciplinary approaches suggest that small vessel diseases are important to understand dementia cases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 8 results) Presentation (14 results) (of which Invited: 2 results) Book (3 results)

  • [Journal Article] Imaging spectrum of sporadic cerebral amyloid angiopathy : multifaceted features of a single pathological condition2014

    • Author(s)
      Sakurai K, Tokumaru AM, Nakatsuka T, Murayama S, Hasebe S, Imabayashi E, Kanemaru K, Takao M, Hatsuta H, Ishii K, Saito Y, Shibamoto Y, Matsukawa N, Chikui E, Terada H
    • Journal Title

      Insights Imaging

      Volume: (in press)

    • URL

      http://link.springer.com/article/10.1007/s13244-014-0312-x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血管性認知症の臨床とその背景, 問題点2014

    • Author(s)
      高尾昌樹
    • Journal Title

      血管医学

      Volume: 15 Pages: 1-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] The Feasibility of White Matter Volume Reduction Analysis using SPM8 plus DARTEL for the Diagnosis of Patients with Clinically Diagnosed Corticobasal Syndrome and Richardson's Syndrome2014

    • Author(s)
      Sakurai K, Imabayashi E, Tokumaru A, Hasebe S, Murayama S, Morimoto S, Kanemaru K, Takao M, Shibamoto Y, Matsukawa N
    • Journal Title

      Neuroimage clinical

      Volume: (in press) Pages: 605-610

    • DOI

      10.1016/j.nicl.2014.02.009

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging spectrum of sporadic cerebral amyloid angiopathy: multifaceted features of a single pathological condition2014

    • Author(s)
      Sakurai K, Tokumaru AM, Nakatsuka T, Murayama S, Hasebe S, Imabayashi E, Kanemaru K, Takao M, Hatsuta H, Ishii K, Saito Y, Shibamoto Y, Matsukawa N, Chikui E, Terada H.
    • Journal Title

      Insights Imaging

      Volume: Feb

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管性認知症の臨床とその背景,問題点2014

    • Author(s)
      髙尾昌樹
    • Journal Title

      血管医学

      Volume: 15 Pages: 1-8

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 軽度認知障害の神経病理2013

    • Author(s)
      高尾昌樹
    • Journal Title

      神経内科

      Volume: 78 Pages: 703-715

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 神経病理基盤に関する今日的理解2013

    • Author(s)
      高尾昌樹
    • Journal Title

      高次脳機能研究

      Volume: 33 Pages: 310-317

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Increased number of astrocytes and macrophages/microglial cells in the corpus callosum in amyotrophic lateral sclerosis2013

    • Author(s)
      Sugiyama M, Takao M, Hatsuta H, Funabe S, Ito S, Obi T, Tanaka F, Kuroiwa Y, Murayama S.
    • Journal Title

      Neuropathology

      Volume: 34 Issue: 6 Pages: 591-9

    • DOI

      10.1111/neup.12027

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuropathologic analysis of Lewy- related alpha- synucleinopathy in olfactory mucosa.2013

    • Author(s)
      Funabe S
    • Journal Title

      Neuropathology

      Volume: 33 Issue: 1 Pages: 47-58

    • DOI

      10.1111/j.1440-1789.2012.01329.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ラクナ梗塞の病理と発症機序2013

    • Author(s)
      高尾昌樹
    • Journal Title

      神経内科

      Volume: 74 Pages: 217-226

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2012

    • Author(s)
      Tsuji H
    • Journal Title

      Brain

      Volume: 135(11) Issue: 11 Pages: 3380-91

    • DOI

      10.1093/brain/aws230

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuropathology of mild cognitive impairment2012

    • Author(s)
      Takao M
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 52 Pages: 851-854

    • NAID

      130004505183

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF-immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum2012

    • Author(s)
      Takahashi M, Ishikawa K, Sato N, Obayashi M, Niimi Y, Ishiguro T, Yamada M, Toyoshima Y, Takahashi H, Kato T, Takao M, Murayama M, Mori O, Eishi Y, Mizusawa H
    • Journal Title

      Neuropathology

      Volume: (in press) Issue: 6 Pages: 593-603

    • DOI

      10.1111/j.1440-1789.2012.01302.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Superficial siderosis associated with abundant tau and α-synuclein accumulation2011

    • Author(s)
      Takao M, Murayama S, Yoshida Y, Mihara B
    • Journal Title

      BMJ Case Reports published online 1 December

      Volume: December Pages: 1-7

    • DOI

      10.1136/bcr.10.2011.4925

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 皮質下梗塞と白質脳症を伴う常染色体劣性脳動脈症(CARASIL)遺伝子診断された3剖検例を用いた病理学的検討2013

    • Author(s)
      伊藤慎治, 高尾昌樹, 仁木利郎, 伊藤信夫, 福武敏夫, 下江豊, 深山正久, 村山繁雄
    • Organizer
      第102回日本病理学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] ブレインバンク研究班 ブレインバンク(BB)に関する調査研究(文科省脳科学研究戦略推進プログラム脳基盤研究)の結果概要報告2013

    • Author(s)
      有馬邦正, 武田伸一, 丸山英二, 松下一章, 木原章子, 服部功太郎, 柿田明美, 豊島靖子, 村山繁雄, 高尾昌樹, 富田博秋, 手嶋豊, 磯部哲, 佐藤雄一郎, 伏木信次, 辻村貴子, 佐藤啓造, 丹羽真一, 武藤香織, 井上悠輔, 辰井聡子, 伊藤雅之, 黒木規臣, 石川 正憲, 齊藤祐子, Lin Crystal
    • Organizer
      第54回日本神経病理学会総会学術研究会
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮質下梗塞と白質脳症を伴う常染色体劣性脳動脈症(CARASIL)遺伝子診断された3剖検例を用いた病理学的検討2013

    • Author(s)
      伊藤慎治,高尾昌樹,仁木利郎,伊藤信夫,福武敏夫,下江豊,深山正久,村山繁雄
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] ブレインバンク研究班 ブレインバンク(BB)に関する調査研究(文科省脳科学研究戦略推進プログラム脳基盤研究)の結果概要報告2013

    • Author(s)
      有馬邦正, 武田伸一, 丸山英二, 松下一章, 木原章子, 服部功太郎, 柿田明美, 豊島靖子, 村山繁雄, 高尾昌樹, 富田博秋, 手嶋豊, 磯部哲, 佐藤雄一郎, 伏木信次, 辻村貴子, 佐藤啓造, 丹羽真一, 武藤香織, 井上悠輔, 辰井聡子, 伊藤雅之, 黒木規臣, 石川 正憲, 齊藤祐子, Lin Crystal
    • Organizer
      第54回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軽度認知障害の背景にある神経病理所見とは2012

    • Author(s)
      高尾昌樹
    • Organizer
      第3回日本血管性認知障害研究会
    • Year and Date
      2012-09-08
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Invited
  • [Presentation] 軽度認知障害の神経病理2012

    • Author(s)
      高尾昌樹
    • Organizer
      第53回日本神経学会総会
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] シンポジムII 「進行性失語」 神経病理基盤に関する今日的理解2012

    • Author(s)
      高尾昌樹
    • Organizer
      第36回日本高次機能障害学会学術総会
    • Related Report
      2013 Final Research Report
  • [Presentation] New Observations in Gerstmann-Straussler-Scheinker Disease Associated with the PRNP A117V Mutation2012

    • Author(s)
      Takao M, Spina S, Murrell J, Epperson F, Glazier B, Farlow M, Unverzagt F, Saykin S, Yoder K, Risacher S, Kepe V, Barrio J
    • Organizer
      The 88th Annual meeting of the American Association of Neuropathologists, Inc
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical and Neuropathologic Heterogeneity in PSEN1 A431E2012

    • Author(s)
      Murrell J, Mehta R, Bigio E, Cairns N, Cochran E, Gitelman D, Head E, Leverenz J, Poon W, Takao M, Weintraub S, Ringman J, Ghetti B
    • Organizer
      The 88th Annual meeting of the American Association of Neuropathologists, Inc
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジムII 「進行性失語」 神経病理基盤に関する今日的理解2012

    • Author(s)
      高尾昌樹
    • Organizer
      第36回日本高次機能障害学会学術総会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] New Observations in Gerstmann-Stra¨ussler-Scheinker Disease Associated with the PRNP A117V Mutation2012

    • Author(s)
      Takao M, Spina S, Murrell J, Epperson F, Glazier B, Farlow M, Unverzagt F, Saykin S, Yoder K, Risacher S, Kepe V, Barrio J.
    • Organizer
      The 88th Annual meeting of the American Association of Neuropathologists, Inc.
    • Place of Presentation
      シカゴ
    • Related Report
      2012 Research-status Report
  • [Presentation] Clinical and Neuropathologic Heterogeneity in PSEN1 A431E2012

    • Author(s)
      Murrell J, Mehta R, Bigio E, Cairns N, Cochran E, Gitelman D, Head E, Leverenz J, Poon W, Takao M, Weintraub S, Ringman J, Ghetti B.
    • Organizer
      The 88th Annual meeting of the American Association of Neuropathologists, Inc.
    • Place of Presentation
      シカゴ
    • Related Report
      2012 Research-status Report
  • [Presentation] 皮質下梗塞と白質脳症を伴う常染色体劣性脳動脈症(CARASIL)の54歳男性剖検例2011

    • Author(s)
      伊藤慎治、高尾昌樹、野上茜、舟辺さやか、初田裕幸、赤津裕康、下江豊、福武敏夫、村山繁雄
    • Organizer
      第98回 日本神経病理学会関東地方会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 皮質下梗塞と白質脳症を伴う常染色体劣性脳動脈症(CARASIL)の54 歳男性剖検例

    • Author(s)
      伊藤慎治, 高尾昌樹, 野上茜, 舟辺さやか, 初田 裕幸, 赤津裕康, 下江豊, 福武敏夫, 村山繁雄
    • Organizer
      第98回日本神経病理学会関東地方会
    • Related Report
      2013 Final Research Report
  • [Book] その他各種検査.中島健二,天野直二,下濱俊,冨本秀和,三村 將 編.認知症ハンドブック2013

    • Author(s)
      髙尾昌樹
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 脳血管性認知症 田中耕太郎、高島修太郎 編.必携脳卒中ハンドブック 改訂第2版2011

    • Author(s)
      高尾昌樹
    • Publisher
      診断と治療社
    • Related Report
      2011 Research-status Report
  • [Book] 脳血管性認知症 田中耕太郎, 高島修太郎 編.必携脳卒中ハンドブック 改訂第2版

    • Author(s)
      高尾昌樹
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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