| Project/Area Number |
23500436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kagawa University (2013)
Institute for Developmental Research, Aichi Human Service Center (2011-2012) |
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Principal Investigator |
CHIBA Yoichi 香川大学, 医学部, 講師 (30372113)
|
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Kikudo 甲子園大学, 栄養学部, 教授 (90211672)
MIURA Koshiro 川崎医科大学, 医学部, 講師 (30284243)
SHIMADA Atsuyoshi 愛知県心身障害者コロニー発達障害研究所, 病理学部, 室長 (50311444)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | オリゴデンドロサイト / プロスタグランジンF2alpha / プロスタグランジン / 脱髄疾患 / 髄鞘 / 軸索保護 / ニューロン・グリア相互作用 |
|---|
| Research Abstract |
Physiological roles of prostaglandin (PG) F2alpha in central nervous system have not been elucidated. We studied the function of PG2alpha in oligodendrocyte-lineage cells, since our previous study revealed oligodendroglial localization of prostamide/PGF synthase, a major PGF2alpha-producing enzyme in mouse central nervous system. We confirmed expression of prostamide/PGF synthase, production of PGF2alpha, and an increase in intracellular calcium concentration in response to exogenous PGF2alpha, in oligodendrocytes. PGF2alpha seemed to be essential for survival of oligodendrocyte-lineage cells in their early development, since oigodendrocyte precursors from prostamide/PGF synthase-knockout mice were not able to survive without PGF2alpha supplementation. In contrast, oligodendrocyte-lineage cells from knockout mice showed normal maturation in response to differentiation stimuli.
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