| Project/Area Number |
23500439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Toyama |
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Principal Investigator |
TOHDA Chihiro 富山大学, 和漢医薬学総合研究所, 准教授 (10272931)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUYA Yuji 富山大学, 大学院・医学薬学研究部(薬学), 教授 (50255858)
KUBOYAMA Tomoharu 富山大学, 和漢医薬学総合研究所, 助教 (10415151)
TESHIGAWARA Kiyoshi 岡山大学, 医歯(薬)学総合研究科, 助教 (40403737)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脊髄損傷 / 軸索伸展 / アストロサイト / vimentin / IGF1受容体 / DARTS法 / デノソミン / Vimentin / Western blotting / 国際情報交換 |
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| Research Abstract |
A novel compound, Denosomin, improved hindlimb motor dysfunction and axonal growth, especially in the 5-hydroxytryptamine (5-HT)-positive tracts across the scar and increased the density of astrocytes. Denosomin increased astrocyte proliferation, inhibited astrocytic death and increased the expression and secretion of vimentin in cultured astrocytes. Furthermore, vimentin treatment increased axonal outgrowth in cultured neurons, even in the presence of inhibitory CSPG. Vimentin-expressing astrocytes increased inside of the glial scars of SCI mice administered Denosomin, and 5-HT-positive axonal growth occurred in a vimentin-associated manner. We firstly found that vimentin stimulated directly IGF1 receptors on neurons and the signaling elicited the axonal growth.
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