Pathomechanisms of anti-NMDA receptor encephalitis

• Project/Area Number: 23500455
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kanazawa Medical University
• Principal Investigator: TANAKA Keiko 金沢医科大学, 医学部, 教授 (30217020)
• Co-Investigator(Renkei-kenkyūsha): KATO Nobuo 金沢医科大学, 医学部, 教授 (10152729)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: グルタミン酸受容体 / NMDA受容体 / 辺縁系脳炎 / 長期増強誘導 / 海馬細胞 / 記銘力障害 / 急性脳炎 / long term potentiation / 病態モデル

Research Abstract

The roles of anti-N-methyl-D-aspartate receptor (NMDAR) antibodies from patients with NMDAR encephalitis on their neurological symptom were examined. The major symptom of NMDAR encephalitis is known as amnesia together with convulsions and other psychiatric symptoms. To reproduce these symptoms, we examined behavior of mice exposed chronically to the cerebrospinal fluid (CSF) from patients and found that mice injected with the CSF exhibited learning impairment. However, their brain tissues did not exhibit inflammatory cell infiltration, neuronal loss, or glial proliferation, and there was no increase in inflammatory cytokines. Thus, for the first time, we showed that the CSF from NMDAR encephalitis patients disturbed the memory function directly in mice. These effects were considered to be functional and without neuronal tissue destruction, which is compatible with the favorable outcome of this disease.

Research Products

• [Journal Article] Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor encephalitis (2014)
  • Author(s): Tabata, E. Masuda, M. Eriguchi, M. Yokoyama, M. Takahashi, Y. Tanaka, K. Yukitake, M, Horikawa, E. Hara, H
  • Journal Title: Eur Neurol Volume: 71 Issue: 1-2 Pages: 42-48
  • DOI: 10.1159/000353982
  • Peer Reviewed
• [Journal Article] Neuronal Antibodies in Creutzfeldt-Jakob Disease (2014)
  • Author(s): K Fujita, K Tanaka, Ytakahashi
  • Journal Title: JAMA Neurol Volume: 71(4) Pages: 514-515
  • Peer Reviewed
• [Journal Article] Details of treatment-related difficulties in men with anti-N-methyl D-aspartate receptor encephalitis. (2013)
  • Author(s): Hikaru Sakamoto, Makito Hirano, Makoto Samukawa, Shuichi Ueno, Shuniji Maekura, Harutoshi Fujimura, Motoi Kuwahara, Yukihiro Hamada, Chiharu Isono, KeikoTanaka, Susumu Kusunoki, Yusaku Nakamura.
  • Journal Title: Eur Neurol Volume: 69 Issue: 1 Pages: 21-26
  • DOI: 10.1159/000342023
  • Peer Reviewed
• [Journal Article] Reduced fingolimod dosage treatment for patients with multiple sclerosis and lymphopenia or neutropenia (2013)
  • Author(s): Masami Tanaka, Kwiyoung Park, and Keiko Tanaka
  • Journal Title: Mult Sclero J Volume: 19 Issue: 9 Pages: 1244-1245
  • DOI: 10.1177/1352458512472750
  • Peer Reviewed
• [Journal Article] Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type (2013)
  • Author(s): Tetsuka, S. Tominaga, K. Ohta, E. Kuroiwa, K. Sakashita, E. Kasashima, K. Hamamoto, T. Namekawa, M. Morita, M. Natsui, S. Morita, T. Tanaka, K. Takiyama, Y. Nakano, I. Endo, H.
  • Journal Title: J Neurol Sci Volume: 335 Issue: 1-2 Pages: 48-57
  • DOI: 10.1016/j.jns.2013.08.022
  • Peer Reviewed
• [Journal Article] Progressive multifocal leukoencephalopathy developed 26 years after renal transplantation. (2013)
  • Author(s): S.Nagayama, Y.Gondo, S.Araya, N. Minato, M.Fujita-Nakata, M.Kaito, M.Nakanishi, K.Tanaka, H.Yamaya, H.Yokoyama, K.Nakamichi, M.Saijo, K.Okamoto, Y.Toyoshima, A.Kakita, M.Matsui.
  • Journal Title: Cli Neurol Neurosurg Volume: 115 Issue: 8 Pages: 1482-1484
  • DOI: 10.1016/j.clineuro.2012.11.016
  • Peer Reviewed
• [Journal Article] Longitudinally extensive spinal cord lesion after initiation,and multiple extensive brain lesions after cessation of fingolimod treatment in a patient with recurrent myelitis and anti-aquaporin4 antibodies (2013)
  • Author(s): M.Tanaka, M.Oono, R.Motoyama, K.Tanaka
  • Journal Title: Clin. Exp. Neuroimmunol. Volume: 4 Pages: 239-240
  • Peer Reviewed
• [Journal Article] 視神経脊髄炎(NMO)/NMO spectrum disorder ―日本人患者における水平性半盲― (2013)
  • Author(s): 朴 貴瑛，田原将行，田中惠子，田中正美
  • Journal Title: 神経内科 Volume: 78 Pages: 118-121
  • Peer Reviewed
• [Journal Article] 卵巣奇形腫を合併し抗NMDA受容体抗体陽性のglioblastomaの1例 (2013)
  • Author(s): 藤井 裕樹, 久保 智司, 柚木 太淳, 佐藤 恒太, 高松 和弘, 田中 惠子, 高橋 幸利, 栗山 勝
  • Journal Title: 臨床神経 Volume: 53 Pages: 712-715
  • NAID: 130004505550
  • Peer Reviewed
• [Journal Article] 抗神経抗体の存在が確認できた膀胱癌を伴う傍腫瘍性小脳変性症の1例 (2013)
  • Author(s): 川西康太郎、森田光哉、中原圭一、手塚修一、幸喜 富、冨永 薫、遠藤仁司、屋代 隆、田中惠子、中野今治
  • Journal Title: Brain Nerve Volume: 65 Pages: 1401-1405
  • Peer Reviewed
• [Journal Article] 両側腓腹部に限局した非進行性神経原性筋萎縮症を呈した孤発例の1例 (2013)
  • Author(s): 原 賢寿, 竪山 真規, 鈴木 直輝, 柴野 健, 田中 恵子, 石黒 英明
  • Journal Title: 臨床神経 Volume: 53 Pages: 551-554
  • NAID: 130004505533
  • Peer Reviewed
• [Journal Article] 多発性硬化症に典型的な脳MRI病変を呈した視神経脊髄炎関連疾患 (2013)
  • Author(s): 朴 貴瑛、小森美華、田中惠子、田中正美
  • Journal Title: 神経内科 Volume: 78 Pages: 477-479
  • Peer Reviewed
• [Journal Article] 意識障害で発症したWaldenstromマクログロブリン血症（Bing-Neel症候群）の一例 (2013)
  • Author(s): 長山成美、湊奈穂美、中多充世、垣内無一、中西恵美、正木康史、田中惠子、松井 真
  • Journal Title: 日本神経救急学会誌 Volume: 25 Pages: 29-32
  • Peer Reviewed
• [Journal Article] 進行する嚥下障害と呼吸不全を呈した高齢発症抗ＳＲＰ抗体陽性ミオパチーの1例 (2013)
  • Author(s): 河合宇吉郎, 藤田充世, 長山成美, 田中惠子, 松井 真
  • Journal Title: 神経内科 Volume: 78 Pages: 579-581
  • Peer Reviewed
• [Journal Article] Stiff-person 症候群と自己抗体 (2013)
  • Author(s): 富岳 亮，田中惠子
  • Journal Title: Brain Nerve Volume: 65 Pages: 395-400
• [Journal Article] 傍腫瘍性神経症候群 (2013)
  • Author(s): 田中惠子
  • Journal Title: 成人病と生活習慣病 Volume: 43 Pages: 485-489
• [Journal Article] 抗アクアポリン(AQP) 4抗体の感度・特異度について教えてください (2013)
  • Author(s): 田中惠子
  • Journal Title: MS Frontier Volume: 2 Pages: 20-21
• [Journal Article] 多発性硬化症の治療 (2013)
  • Author(s): 田中正美、田中惠子
  • Journal Title: 日本内科学会雑誌 Volume: 8 Pages: 1971-1977
• [Journal Article] 抗NMDAR抗体と神経疾患 (2013)
  • Author(s): 田中惠子
  • Journal Title: 神経内科 Volume: 79 Pages: 341-347
• [Journal Article] 傍腫瘍性神経症候群 (2013)
  • Author(s): 田中惠子
  • Journal Title: 日本医師会雑誌 Volume: 142 Pages: 259-260
• [Journal Article] 自己免疫性脳炎・脳症とアフェレーシス (2013)
  • Author(s): 田中惠子
  • Journal Title: 日本アフェレシス学会雑誌 Volume: 32 Pages: 191-197
  • NAID: 110009661553
• [Journal Article] NMDA受容体に対する自己免疫抗体 (2013)
  • Author(s): 筒井 幸、神林 崇、田中惠子、清水徹男
  • Journal Title: 生体の科学 Volume: 64 Pages: 442-443
• [Journal Article] Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features (2012)
  • Author(s): K Tsutsui, T Kanbayashi, K Tanaka, S Boku, W Ito, J Tokunaga, A Mori, Y Hishikawa, T Shimizu, S Nishino
  • Journal Title: BMC Psychiatry Volume: 12 Issue: 1 Pages: 37-37
  • DOI: 10.1186/1471-244x-12-37
  • NAID: 10031128536
  • Peer Reviewed
• [Journal Article] Suppression of synaptic plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients (2012)
  • Author(s): Zhang Q
  • Journal Title: Neurobiol Dis. Volume: 45(1) Issue: 1 Pages: 610-615
  • DOI: 10.1016/j.nbd.2011.09.019
  • Peer Reviewed
• [Journal Article] Relationship between NMO-antibody and anti-MOG antibody in optic neuritis (2012)
  • Author(s): T Kezuka, et al.
  • Journal Title: J Neuro-Ophthalmology Volume: 32 Pages: 107-110
  • Peer Reviewed
• [Journal Article] Detection of anti-glutamate receptor e2 and anti-N-methyl D-aspartate receptor antibodies in a patient with sporadic Creutzfeldt-Jakob disease (2012)
  • Author(s): K Fujita, et al.
  • Journal Title: J Neurol Volume: 259 Pages: 985-988
  • Peer Reviewed
• [Journal Article] Heterozygous UDP-GlcNAc 2-epimerase and N-acetylmannosamine kinase domain mutations in the GNE gene result in a less severe GNE myopathy phenotype compared to homozygous N-acetylmannosamine kinase domain mutations (2012)
  • Author(s): M Mori-Yoshimura, et al.
  • Journal Title: J Neurol Sci Volume: 318 Pages: 100-105
  • Peer Reviewed
• [Journal Article] Cortical and leptomeningeal involvement in three cases of neuromyelitis optica (2012)
  • Author(s): M Tahara, et al.
  • Journal Title: Eur J Neurol Volume: 19 Pages: 47-48
  • Peer Reviewed
• [Journal Article] Antibodies to N-methyl-D-aspartate glutamate receptors in Creutzfeldt–Jakob disease patients (2012)
  • Author(s): K Fujita, et al.
  • Journal Title: J Neuroimmunol Volume: 251 Pages: 90-93
  • Peer Reviewed
• [Journal Article] A case of anti-Hu-associated paraneoplastic encephalomyelitis with esophageal small cell carcinoma (2012)
  • Author(s): T Shirafuji, et al.
  • Journal Title: Int Med Volume: 51 Pages: 2423-2427
  • Peer Reviewed
• [Journal Article] Increased prevalence, incidence, and female predominance of multiple sclerosis in northern Japan (2012)
  • Author(s): H Houzen, et al.
  • Journal Title: J Neurol Sci Volume: 323 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism (2012)
  • Author(s): T Serikawa, et al.
  • Journal Title: BMC Neurol Volume: 11 Pages: 72-74
  • Peer Reviewed
• [Journal Article] Anti-NMDAR encephalitis in small-cell lung cancer:A case report (2012)
  • Author(s): A Uruha, et al.
  • Journal Title: Clinical Neurology and Neurosurgery Volume: 114 Pages: 260-261
  • Peer Reviewed
• [Journal Article] Autoimmune neurological disorders associated with group-A beta-hemolytic streptococcal infection (2012)
  • Author(s): Y Hachiya, et al.
  • Journal Title: Brain Dev Volume: in press
  • Peer Reviewed
• [Journal Article] Chorea as the First Sign in a Patient with Elderly- Onset Systemic Lupus Erythematosus (2012)
  • Author(s): Y Ariizumi,et al.
  • Journal Title: Case Reports in Neurological Medicine Volume: in press Pages: 317082-317082
  • DOI: 10.1155/2012/317082
  • Peer Reviewed
• [Journal Article] Anti-aquaporin 4 antibody binding character in clinical subtypes of neuromyelitis optica (2012)
  • Author(s): A Nagaishi, et al.
  • Journal Title: Clinical and Experimental Neuroimmunology Volume: 3 Pages: 109-115
  • Peer Reviewed
• [Journal Article] Clinical and magnetic resonance imaging features of multiple sclerosis with autoreactive antibodies in Ishikawa Prefecture, Japan (2012)
  • Author(s): K Takahashi ,et al.
  • Journal Title: J Neuroimmunol Volume: 250 Pages: 111-114
  • Peer Reviewed
• [Journal Article] 早期の集中的な免疫療法が奏功した抗NMDA受容体脳炎の１例 (2012)
  • Author(s): 高山文美、ら
  • Journal Title: 神経内科 Volume: 76 Pages: 96-99
  • Peer Reviewed
• [Journal Article] 抗菌薬と副腎皮質ステロイド薬の併用が有効であった神経ボレリア症の１例 (2012)
  • Author(s): 高堂裕平、ら
  • Journal Title: 臨床神経学 Volume: 52 Pages: 411-415
  • Peer Reviewed
• [Journal Article] 抗NMDA受容体抗体が陽性であった脳炎，統合失調症，精神症状を伴うナルコレプシーの症例 (2012)
  • Author(s): 筒井 幸，ら
  • Journal Title: Jpn I Gen Hosp Psychiatry Volume: 24 Pages: 40-50
  • Peer Reviewed
• [Journal Article] 間接蛍光抗体法（IF法）による抗NMDA受容体抗体測定キットの検討 (2012)
  • Author(s): 田中惠子，ら
  • Journal Title: 医学と薬学 Volume: 68 Pages: 135-138
  • Peer Reviewed
• [Journal Article] 日本人 clinically isolated syndrome 患者の脳 MRI 所見 (2012)
  • Author(s): 田中 正美, ら
  • Journal Title: 臨床神経 Volume: 52 Pages: 725-729
  • NAID: 130004505027
  • Peer Reviewed
• [Journal Article] 短期記憶障害を呈し抗 Ma2 抗体,抗 NMDAR 抗体,抗 GluRε2 抗体 陽性で,後に精巣腫瘍をみとめた傍腫瘍性辺縁系脳炎の 1 例 (2012)
  • Author(s): 久保田昭洋,ら
  • Journal Title: 臨床神経 Volume: 52 Pages: 666-671
  • Peer Reviewed
• [Journal Article] 緊張病と診断されたN-methy-D-aspartate受容体脳炎/脳症 (2012)
  • Author(s): 安藤喜仁、ら
  • Journal Title: 神経治療 Volume: 29 Pages: 767-771
  • Peer Reviewed
• [Journal Article] 傍腫瘍性神経症候群 in 特集：圧迫性脊椎脊髄疾患と鑑別を要する神経・筋疾患 (2012)
  • Author(s): 田中惠子
  • Journal Title: 脊椎脊髄ジャーナル Volume: 25 Pages: 131-140
• [Journal Article] 傍腫瘍性神経症候群 (2012)
  • Author(s): 田中惠子
  • Journal Title: 内科 Volume: 109 Pages: 934-937
• [Journal Article] NMOの病態機序におけるAQP4抗体の意義 (2012)
  • Author(s): 田中惠子
  • Journal Title: 神経内科 Volume: 76 Pages: 583-588
• [Journal Article] Assembly defect due to a PSMB8 mutation reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome (2011)
  • Author(s): Arima, K., Kinoshita, A., Mishima, H., Kanazawa, N., Kaneko, T., Mizushima, T., Ichinose, K., Nakamura, H., Tsujino, A., Kawakami, A., Matsunaka, M., Kasagi, S., Kawano, S., Kumagai, S., Ohmura, K., Mimori, T., Hirano, M., Ueno, S., Tanaka, K., Tanaka, M., Toyoshima, I., Sugino, H., Yamakawa, A., Tanaka, K., Niikawa, N., Furukawa, F., Murata, S., Eguchi, K., Ida, H., Yoshiura, K.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Issue: 36 Pages: 14914-14919
  • DOI: 10.1073/pnas.1106015108
  • Peer Reviewed
• [Journal Article] Clinical features of neuromyelitis optica in a large Japanese cohort : comparison between phenotypes (2011)
  • Author(s): Nagaishi A
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 82(12) Issue: 12 Pages: 1360-4
  • DOI: 10.1136/jnnp-2011-300403
  • Peer Reviewed
• [Journal Article] Assembly defect due Q:1 to a PSMB8 mutation ; 2 reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome (2011)
  • Author(s): K Arima, et al.
  • Journal Title: PNAS Volume: 36 Pages: 14914-14919
  • Peer Reviewed
• [Journal Article] Clinical features of neuromyelitis optica in a large Japanese cohort: comparison between phenotypes (2011)
  • Author(s): A Nagaishi, et al.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 82 Pages: 1360-1364
  • Peer Reviewed
• [Journal Article] A young man with anti-NMDAR encephalitis following Guillain-Barre syndrome. (2011)
  • Author(s): K Tojo, et al.
  • Journal Title: Case Reports in Neurology Volume: 3 Pages: 7-13
  • Peer Reviewed
• [Journal Article] Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonis (2011)
  • Author(s): T Serikawa, et al.
  • Journal Title: BMC Neurology Volume: 11 Pages: 72-72
  • Peer Reviewed
• [Journal Article] 日本人多発性硬化症・視神経脊髄炎患者の死因 (2011)
  • Author(s): 田中正美ら
  • Journal Title: 神経内科 Volume: 74 Pages: 604-606
  • Peer Reviewed
• [Journal Article] Mitoxantrone治療中に帯状疱疹ウィルスによる髄膜炎を呈したNeuromyelitis opticaの1例 (2011)
  • Author(s): 中野 仁ら
  • Journal Title: 臨床神経学 Volume: 51 Pages: 703-705
  • Peer Reviewed
• [Journal Article] 免疫療法が有効であった腫瘍非合併抗NMDA受容体脳炎の2例 (2011)
  • Author(s): 北田茉里ら
  • Journal Title: 臨床神経学 Volume: 51 Pages: 683-687
  • Peer Reviewed
• [Journal Article] 神経症状と自己抗体がガイドする悪性腫瘍の早期発見 (2011)
  • Author(s): 田中惠子
  • Journal Title: Medical Science Digest Volume: 37 Pages: 130-131
• [Journal Article] 神経疾患治療ノート 傍腫瘍性神経症候群 (2011)
  • Author(s): 田中惠子
  • Journal Title: Clinical Neuroscience Volume: 29 Pages: 600-601
• [Journal Article] 神経系の腫瘍随伴症候群 (2011)
  • Author(s): 田中惠子
  • Journal Title: Cross Cancer Research 8 Volume: 2 Pages: 14-15
• [Journal Article] ウィルス性脳炎との鑑別診断に重要な自己抗体介在性脳炎 (2011)
  • Author(s): 田中惠子
  • Journal Title: Neuroinfection Volume: 16 Pages: 19-26
• [Presentation] Autoantibodies other than anti-AQP4 antibodies in seronegative NMO patients (2013)
  • Author(s): K Tanaka, M Matsui, M Tanaka
  • Organizer: 6th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Kyoto
  • Year and Date: 2013-11-07
• [Presentation] Immunological profiles of the CSF from the anti-NMDA receptor encephalitis patient (2013)
  • Author(s): K Tanaka, M Fujita, M Matsui, T Takegami
  • Organizer: World Congress of Neurology
  • Place of Presentation: Wien
  • Year and Date: 2013-09-26
• [Presentation] Effects of the CSF from anti-NMDAR encephalitis patient on the cultured neurons (2013)
  • Author(s): K Tanaka, M. Fujita, Y Ishigaki, N.Kato, M Matsui, M Tanaka, T Takegami
  • Organizer: 65th AAN Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Immunological profiles of the CSF from the anti-NMDA receptor encephalitis patient (2013)
  • Author(s): Keiko Tanaka, Michiyo Fujita, Makoto Matsui, TsutomuTakegami
  • Organizer: World Congress of Neurology
  • Place of Presentation: Reed Messe Wien GmbH, Congress center, Wien, Austria
• [Presentation] Intractable Cough May Be Characteristic Symptom of Neuromyelitis Optica (2013)
  • Author(s): M.Fujita-Nakata, R.Tomioka, K.Tanaka, M.Nakanishi, S.Nagayama, R.Takahashi, T.Machiya, T.Hamada, M.Matsui
  • Organizer: 6th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Westin Hotel, Kyoto, Japan
• [Presentation] Autoantibodies other than anti-AQP4 antibodies in seronegative NMO patients (2013)
  • Author(s): K.Tanaka, M.Matsui, M.Tanaka
  • Organizer: 6th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Westin Hotel, Kyoto, Japan
• [Presentation] Effects of the CSF from anti-NMDAR encephalitis patient on the cultured neurons (2013)
  • Author(s): K Tanaka, M. Fujita, Y Ishigaki, N.Kato, M Matsui, M Tanaka, T Takegami
  • Organizer: 65th AAN Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] 自己免疫性脳炎の最近の話題 (2013)
  • Author(s): 田中惠子
  • Organizer: 第23回京都内科神経懇話会
  • Place of Presentation: 京都（京都センチュリーホテル）
  • Invited
• [Presentation] 自己抗体が介在する脳炎・脳症 (2013)
  • Author(s): 田中惠子
  • Organizer: 第7回Saitama Neurological Seminar
  • Place of Presentation: さいたま市（浦和ロイヤルパインズホテル）
  • Invited
• [Presentation] Effects of anti-NMDA receptor antibodies from the patients with NMDA receptor encephalitis on the neurons (2012)
  • Author(s): K. Tanaka, Y. Ishigaki, T.Takegami, M.Tanaka, M.Matsui, N. Kato
  • Organizer: 11 th International Congress of Neuroimmunology
  • Place of Presentation: Boston
  • Year and Date: 2012-11-06
• [Presentation] A large Japanese cohort study for AQP4 antibody-positive cases (2012)
  • Author(s): K.Tanaka
  • Organizer: PACTRIMS
  • Place of Presentation: Beijing
  • Year and Date: 2012-09-14
• [Presentation] Clinical profile of Japanese patients with anti-NMDAR encephalitis and functional analysis of the anti-NMDAR antibodies (2012)
  • Author(s): K Tanaka
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-23
• [Presentation] A large Japanese cohort study for AQP4 antibody-positive cases. (2012)
  • Author(s): K.Tanaka.
  • Organizer: PACTRIMS
  • Place of Presentation: Beijing, China
  • Invited
• [Presentation] Effects of anti-NMDA receptor antibodies from the patients with NMDA receptor encephalitis on the neurons (2012)
  • Author(s): K. Tanaka, Y. Ishigaki, T.Takegami, M.Tanaka, M.Matsui, N. Kato.
  • Organizer: 11th International Congress of Neuroimmunology
  • Place of Presentation: Boston, USA
• [Presentation] Clinical profile of Japanese patients with anti-NMDAR encephalitis and functional analysis of the anti-NMDAR antibodies (2012)
  • Author(s): Keiko Tanaka
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京（東京国際フォーラム）
  • Invited
• [Presentation] 抗NMDA受容体脳炎患者髄液による疾患モデルを用いた病態の解析 (2012)
  • Author(s): 田中惠子
  • Organizer: 第24回日本神経免疫学会学術集会
  • Place of Presentation: 軽井沢（軽井沢プリンスホテル）
• [Presentation] 自己免疫性脳炎とてんかん (2012)
  • Author(s): 田中惠子
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 東京（都市センターホテル）
  • Invited
• [Presentation] 視神経脊髄炎と抗アクアポリン４抗体 (2012)
  • Author(s): 田中惠子
  • Organizer: 第21回日本神経学会中国四国地方会 生涯教育講演会
  • Place of Presentation: 徳島（あわぎんホール）
  • Invited
• [Presentation] 自己抗体がガイドする傍腫瘍性神経症候群 (2012)
  • Author(s): 田中惠子
  • Organizer: 第57回日本病理学会関東支部学術集会
  • Place of Presentation: 東京（東京女子医科大学弥生記念講堂）
  • Invited
• [Presentation] Clinical features of NMO in a large cohort in Japan (2012)
  • Author(s): Keiko Tanaka
  • Organizer: Sendai Conference 2012
  • Place of Presentation: 仙台（トラストシティカンファランス仙台）
  • Invited
• [Presentation] 自己抗体がガイドする傍腫瘍性神経症候群 (2012)
  • Author(s): 田中惠子
  • Organizer: 第１回東京神経難病フォーラム
  • Place of Presentation: 東京（京王プラザホテル）
  • Invited
• [Presentation] 自己免疫性チャネロパチー (2012)
  • Author(s): 田中惠子
  • Organizer: 第14回神奈川県神経免疫フォーラム
  • Place of Presentation: 横浜（崎陽軒本店ビル）
  • Invited
• [Presentation] てんかんを主徴とする NMDA 受容体脳炎 - 抗体の神経機能に及ぼす効果 (2011)
  • Author(s): 田中惠子, 本山りえ, 中多 充世, 田中正美, 松井 真, 加藤伸郎
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-06
• [Presentation] 抗 NMDA 受容体抗体と神経疾患 (2011)
  • Author(s): 田中惠子
  • Organizer: 日本神経免疫学会学術集会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-09-17
• [Presentation] 抗 NMDA 受容体抗体の神経機能に及ぼす効果 (2011)
  • Author(s): 田中惠子, 中多充世, 松井 真, 加藤伸郎
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] Functional effects of the CSF from anti-NMDA receptor encephalitis patient on NMDAR-mediated synaptic transmission (2011)
  • Author(s): K Tanaka, M Nakata, Q Zhang, P Sun, K Sakimura, M Matsui, N Kato
  • Organizer: 64th American Academy of Neurology Annual Meeting
  • Place of Presentation: Hawaii
  • Year and Date: 2011-04-14
• [Presentation] Functional effects of the CSF from anti-NMDA receptor encephalitis patient on NMDAR-mediated synaptic transmission (2011)
  • Author(s): K Tanaka,et al.
  • Organizer: 64th American Academy of Neurology Annual Meeting
  • Place of Presentation: Hawaii, USA
• [Presentation] 自己抗体が介在する免疫性神経疾患
  • Author(s): 田中惠子
  • Organizer: 第 54 回日本神経学会学術大会 イブニングセミナー
  • Place of Presentation: 東京国際フォーラム，東京都千代田区
  • Invited
• [Presentation] 免疫介在性機序による小脳失調症
  • Author(s): 田中惠子
  • Organizer: 厚生労働科学研究費補助金 難治性疾患克服研究事業 「運動失調症の病態解明と治療法開発に関する研究」班 平成25年度ワークショップ
  • Place of Presentation: 都市センターホテル，東京都千代田区
  • Invited
• [Presentation] 傍腫瘍性神経症候群の診断と治療
  • Author(s): 田中惠子
  • Organizer: 第31回日本神経治療学会総会
  • Place of Presentation: 東京ドームホテル，東京都文京区
  • Invited
• [Presentation] NMDA受容体脳炎における炎症病態の検討
  • Author(s): 田中惠子，李 永智、藤田充世，松井 真，加藤伸郎、石垣靖人、竹上 勉
  • Organizer: 第 54 回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム，東京都千代田区
• [Presentation] 細菌性髄膜炎に対する抗生剤で惹起された薬剤誘発性髄膜炎の1例
  • Author(s): 長山成美, 中西恵美, 田中惠子, 松井 真
  • Organizer: 第31回日本神経治療学会総会
  • Place of Presentation: 東京ドームホテル，東京都文京区
• [Presentation] 右第VII・IX・X脳神経障害をきたし、第VIII脳神経は保たれたRamsay-Hunt症候群variantの1例
  • Author(s): 長山成美, 井上 穣, 藤田充世, 中西恵美, 富岳 亮, 田中惠子, 松井 真
  • Organizer: 第18回日本神経感染症学会総会
  • Place of Presentation: シーガイア，宮崎市山崎町
• [Presentation] 抗NMDAR抗体陽性脳炎の動物モデル作製と認知行動解析
  • Author(s): 田中惠子，李 永智，竹上 勉，加藤伸郎，松井 真
  • Organizer: 免疫性神経疾患研究班 班会議
  • Place of Presentation: 都市センターホテル，東京都千代田区
• [Presentation] NMOと抗AQP4抗体
  • Author(s): 田中惠子
  • Organizer: 第14回神奈川免疫性脳・神経疾患研究会
  • Place of Presentation: 崎陽軒本店会議場，横浜市西区
  • Invited
• [Presentation] 視神経髄炎―疾患カテゴリーとしての変遷
  • Author(s): 田中惠子
  • Organizer: 講演会 in 福島
  • Place of Presentation: ホテル辰巳，福島市
  • Invited
• [Book] 傍腫瘍性小脳変性症 別冊日本臨床 新領域別症候群シリーズ 神経症候群(第2 版) - その他の神経疾患を含めてー II IV 自己免疫性疾患 傍腫瘍性神経症候群 (2014)
  • Author(s): 田中惠子
• [Book] 悪性腫瘍に伴う神経系障害内科学第10 版 矢崎義雄 総編集 (2013)
  • Author(s): 田中惠子
  • Publisher: 朝倉書店
• [Book] 自己免疫性脳炎・脳症 免疫性神経疾患ハンドブック楠進編集 (2013)
  • Author(s): 田中惠子
  • Publisher: 南江堂
• [Book] 傍腫瘍性神経症候群 今日の神経疾患治療指針 水澤英洋, 鈴木則宏, 梶 龍兒, 吉良潤一, 神田 隆, 齋藤 延人 編 (2013)
  • Author(s): 田中惠子
  • Publisher: 医学書院
• [Book] 多発性硬化症 今日の治療と看護 改定第3 版 永井良三 / 大田健 編集 (2013)
  • Author(s): 田中惠子
  • Publisher: 南江堂
• [Book] 免疫性神経疾患ハンドブック (2013)
  • Author(s): 田中惠子
  • Total Pages: 348
  • Publisher: 南江堂
• [Book] 内科学第10版 (2013)
  • Author(s): 田中惠子
  • Total Pages: 2404
  • Publisher: 朝倉書店
• [Book] 今日の治療と看護 改定第3版 (2013)
  • Author(s): 田中惠子
  • Total Pages: 1467
  • Publisher: 南江堂
• [Book] 今日の神経疾患治療指針 (2013)
  • Author(s): 田中惠子
  • Total Pages: 1100
  • Publisher: 医学書院
• [Book] 抗アクアポリン 4 抗体 アクチュアル脳・神経疾患の臨床 多発性硬化症と視神経脊髄炎 総編集 辻省次, 専門編集吉良潤一 (2012)
  • Author(s): 田中惠子
  • Publisher: 中山書店
• [Book] 抗アクアポリン4抗体の測定法と診断的意義 多発性硬化症 (MS)と視神経脊髄炎 (NMO) の基礎と臨床医薬ジャーナル社藤原一男編 (2012)
  • Author(s): 田中惠子
• [Book] 多発性硬化症 内科学 門脇 孝, 永井良三 編集 (2012)
  • Author(s): 田中惠子
  • Publisher: 西村書店
• [Book] 視神経脊髄炎 内科学 門脇 孝, 永井良三 編集 (2012)
  • Author(s): 田中惠子
  • Publisher: 西村書店
• [Book] 急性散在性脳脊髄炎 内科学 門脇 孝, 永井良三 編集 (2012)
  • Author(s): 田中惠子
  • Publisher: 西村書店
• [Book] 傍腫瘍性神経症候群 内科学 門脇 孝, 永井良三 編集 (2012)
  • Author(s): 田中惠子
  • Publisher: 西村書店
• [Book] 多発性硬化症 (MS) と視神経脊髄炎 (NMO) の基礎と臨床 (2012)
  • Author(s): 田中惠子
  • Total Pages: 263
  • Publisher: 医薬ジャーナル社
• [Book] 内科学 (2012)
  • Author(s): 田中惠子
  • Total Pages: 1929
  • Publisher: 西村書店
• [Book] アクチュアル脳・神経疾患の臨床 多発性硬化症と視神経脊髄炎 (2012)
  • Author(s): 田中惠子
  • Total Pages: 410
  • Publisher: 中山書店
• [Book] 今日の治療指針 2012版 (2012)
  • Author(s): 田中惠子
  • Total Pages: 1955
  • Publisher: 医学書院
• [Book] 自己抗体が関連する傍腫瘍性・自己免疫性脳炎・脳症 . 「小児科臨床ピクシス」 28 急性脳炎・急性脳症総編集 : 五十嵐 隆, 専門編集 : 塩見正司 (2011)
  • Author(s): 田中惠子
  • Publisher: 中山書店
• [Book] 「小児科臨床ピクシス」 28 急性脳炎・急性脳症 (2011)
  • Author(s): 田中 惠子
  • Total Pages: 232
  • Publisher: 中山書店