Functional maturation of the control of the mammalian spinal locomotor network
| Project/Area Number |
23500460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOGANEZAWA Tadachika 筑波大学, 医学医療系, 助教 (80431691)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経回路 / 歩行 / 運動 / マウス / 脊髄 / 神経科学 / 生理学 / ニューロン / シナプス |
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| Research Abstract |
In this study we used genetically-modified mice that show abnormal gait to investigate the function and maturation of the locomotor network in the spinal cord especially how it is controlled by the supraspinal structures. Our findings suggest that the corticospinal tract plays little role in the development of the spinal locomotor network and that a population of EphA4-positive spinal excitatory neurons play a significant role in the normal development of the mammalian locomotor circuit.
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Report
(4 results)
Research Products
(20 results)
