Regulation of extinction of emotional memory by amygdaloid neural circuits
| Project/Area Number |
23500462
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Gunma University |
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Principal Investigator |
MIWA Hideki 群馬大学, 医学(系)研究科(研究院), 助教 (80468488)
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| Co-Investigator(Renkei-kenkyūsha) |
YANAGAWA Yuchio 群馬大学, 大学院・医学系研究科, 教授 (90202366)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 扁桃体 / GABA作動性ニューロン / Ca2+結合タンパク質 / 神経ペプチド / 情動 / 記憶 / 消去 / GABA / 免疫組織化学 / 恐怖 |
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| Research Abstract |
Using vesicular GABA transporter (VGAT)-Venus transgenic mice, in which GABAergic neurons are labeled with the Venus fluorescent protein, the immunohistochemical characterization of GABAergic neurons in the amygdala was performed. As a result, nerve terminal-like signals of somatostatin (SST) and vasoactive intestinal peptide (VIP) in the central nucleus of the amygdala were observed. These results suggest that SST and VIP have unique roles in regulation of extinction of fear memory.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.2012
Author(s)
Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., Sato, Y., Saruta, C., Miwa, H., Tanaka, M., Itohara, S., and Furuichi, T.
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Journal Title
Proc. Natl. Acad. Sci. U.S.A.
Volume: 109
Issue: 51
Pages: 21104-21109
DOI
Related Report
Peer Reviewed
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