A novel function of AMPK in nervous system, especially for circadian clock and sensory systems
| Project/Area Number |
23500478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fusional basic brain science
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
Nakamura Atsushi 電気通信大学, 情報理工学(系)研究科, 助教 (50361829)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tadashi 電気通信大学, 大学院情報理工学研究科, 教授 (50217858)
YOSHIKAWA Tomoko 北海道大学, 大学院医学研究科, 特任助教 (30451397)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 概日時計 / AMPK / 視交叉上核 / 感覚受容 / 感覚 |
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| Outline of Final Research Achievements |
The circadian clock has an about 24 hour periods. The central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, and controls many circadian rhythms. In this study, we examined the role of AMP-activated protein kinase (AMPK) in the regulation of the circadian rhythms. Addition of the activator of AMPK to the cultured SCN caused the elongation of the circadian period. This suggests the implication of AMPK for the circadian clockwork in the SCN. Next, we investigated the localization of the substrates for AMPK in the SCN by immunohistochemistry. They were found in the ventral region in the SCN.
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Report
(6 results)
Research Products
(18 results)
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[Journal Article] CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms.2014
Author(s)
Kon N, Yoshikawa T, Honma S, Yamagata Y, Yoshitane H, Shimizu K, Sugiyama Y, Hara C, Kameshita I, Honma K, Fukada Y.
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Journal Title
Genes Dev
Volume: 28
Issue: 10
Pages: 1101-1110
DOI
Related Report
Peer Reviewed / Open Access
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