Frequency analysis of ictal MEG data for establishment as a non-invasive examination of epileptic localization

• Project/Area Number: 23500481
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Fusional brain recording science
• Research Institution: Hiroshima University
• Principal Investigator: IIDA Koji 広島大学, 大学病院, 講師 (20304412)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: てんかん / 脳磁図 / 頭蓋内脳波

Outline of Final Research Achievements

Ictal magnetoencephalographic (MEG) data was analyzed using gradient magnetic-field topography (GMFT) to elucidate whether or not the results was correlated with simultaneous recording of intracranial EEG. The seizure was recorded in 1 of 3 patients with mesial temporal lobe epilepsy, in whom the GMFT failed to capture ictal discharges localized to mesial temporal region on intracranial EEG. In 3 of 4 patients with neocortical epilepsy, GMFT showed dynamic changes of interictal spikes similar to those on intracranial EEG. Furthermore, we applied GMFT spike analysis to symptomatic generalized epilepsy with drop attacks. The high spatio-temporal resolution of GMFT can reveal the anterior/posterior predominant distribution and the spreading pattern of secondary bilateral synchronized generalized spikes in patients with drop attacks.

Research Products

• [Journal Article] Magnetoencephalography using gradient magnetic field topography (GMFT) can predict successful anterior corpus callosotomy in patients with drop attacks. (2015)
  • Author(s): Kagawa K, Iida K, Hashizume A, Katagiri M, Baba S, Kurisu K, Otsubo H
  • Journal Title: Clin Neurophysiol Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Electrocorticographic–Histopathologic Correlations Implying Epileptogenicity of Dysembryoplastic Neuroepithelial Tumor (2013)
  • Author(s): Kagawa K, Iida K, Kakita A, Katagiri M, Nishimoto T, Hashizume A, Kiura Y, Hanaya R, Sugiyama K, Arihiro K, Arita K, Kurisu K
  • Journal Title: Neurologia medico-chirurgica Volume: 53 Issue: 10 Pages: 676-687
  • DOI: 10.2176/nmc.oa2012-0420
  • NAID: 10031191637
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed
• [Presentation] 脳磁図は手術計画にどこまで寄与し得るか -脳磁図・頭蓋内脳波同時計測による傾斜磁場トポグラフィ(GMFT)焦点診断能の検証- (2015)
  • Author(s): 香川幸太、飯田幸治、橋詰 顕、片桐匡弥、岐浦禎展、花谷亮典、有田和徳、栗栖 薫
  • Organizer: 第38回日本てんかん外科学会
  • Place of Presentation: 東京
  • Year and Date: 2015-01-15 – 2015-01-16
• [Presentation] Evaluation of the changes in interictal magnetoencephalography (MEG) spikes by gradient magnetic field topography (GMFT) before and after anterior corpus callosotomy for symptomatic generalized epilepsy with drop-attacks (2014)
  • Author(s): Kota Kagawa, Koji Iida, Akira Hashizume, Masaya Katagiri, Siro Baba, Kaoru Kurisu, Hiroshi Otsubo
  • Organizer: Annual meeting of the American Epilepsy Society
  • Place of Presentation: 米国シアトル
  • Year and Date: 2014-12-05 – 2014-12-09
• [Presentation] 脳磁図-頭蓋内脳波同時記録に基づく傾斜磁場トポグラフィー(GMFT)解析の皮質焦点診断能についての検証 (2014)
  • Author(s): 香川幸太、飯田幸治、橋詰 顕、片桐匡弥、岐浦禎展、花谷亮典、有田和徳、栗栖 薫
  • Organizer: 第48回日本てんかん学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-02 – 2014-10-03
• [Presentation] Integrating magnetic-source and functional imaging for neuronavigation of electrode implantation and resection of focal cortical dysplasia in patients (2011)
  • Author(s): Iida K, Kagawa K, Nishimoto T, Hashizume A, Kiura Y, Hanaya R, Arita K, Kurisu K
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome, Italy