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A study of the correlation between hippocampal sclerosis of temporal lobe epilepsy and focal cortical dysplasia

Research Project

Project/Area Number 23500498
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory animal science
Research InstitutionKyushu University

Principal Investigator

TAKASE Kei-ichiro  九州大学, 医学(系)研究科(研究院), 研究員 (00467903)

Co-Investigator(Kenkyū-buntansha) SHIGETO Hiroshi  九州大学, 大学病院, 講師 (50335965)
KAMADA Takashi  九州大学, 大学病院, 術研究員 (70614460)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords実験てんかん / 皮質異形性 / 側頭葉てんかん / 海馬硬化症
Research Abstract

On embryonic day (E) 18, a frozen probe was placed on the frontal scalp of a Sprague-Dawley rat embryo through the uterus wall to produce multiple (two to four) freeze lesions on each hemisphere. Rats were divided into group A (four freeze lesions) and group B (two freeze lesions). EEG video monitoring for rat pups was performed from postnatal day (P) 35 to P77. Brain tissue was examined by immunohistochemistry, including semi-quantitative densitometry. 68.8% of the rats with multiple FCDs showed spontaneous hippocampal seizures which began by movement cessation and culminated in wet-dog shakes during periods of hippocampal discharge, from P47 onwards. Furthermore, immunoreactivities for N-methyl-D-aspartate receptors and glutamate transporters both in FCD lesions and in hippocampi were significantly enhanced compared to controls. Prenatal freeze-lesioning of the brain during embryonic development leads to spontaneous temporal lobe seizures in a rat model with multiple FCDs.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 2 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior2013

    • Author(s)
      Yutsudo N, Kamada T, Kajitani K, Nomaru H, Katogi A, Ohnishi YH, Ohnishi YN, Takase K, Sakumi K, Shigeto H, Nakabeppu Y
    • Journal Title

      Neuropsychopharmacology

      Volume: 38 Pages: 895-906

    • Related Report
      2013 Final Research Report
  • [Journal Article] Spontaneous seizures in a rat model of multiple prenatal freeze lesioning2013

    • Author(s)
      Kamada T, Sun W, Takase K, Shigeto H, Suzuki SO, Ohyagi Y, Kira J
    • Journal Title

      Epilepsy Res

      Volume: 105(3) Pages: 280-91

    • Related Report
      2013 Final Research Report
  • [Journal Article] Systematic study of the effects of stimulus parameters and stimulus location on afterdischarges elicited by electrical stimulation in the rat2013

    • Author(s)
      Shigeto H, Boongird A, Baker K, Kellinghaus C, Najm I, Lüders H
    • Journal Title

      Epilepsy Res

      Volume: 104 Pages: 17-25

    • Related Report
      2013 Final Research Report
  • [Journal Article] fosB-Null Mice Display Impaired Adult Hlppocampal Neurogenesis and Spontaneous Epilepsy2013

    • Author(s)
      Yutsudo, N, et. al.
    • Journal Title

      Neuropsychopharmacology

      Volume: 38 Issue: 5 Pages: 895-906

    • DOI

      10.1038/npp.2012.260

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous seizures in a rat model of multiple prenatal freeze lesioning.2013

    • Author(s)
      Kamada T, Sun W, Takase K, Shigeto H, Suzuki SO, Ohyagi Y, Kira J.
    • Journal Title

      Epilepsy Res

      Volume: 105 Issue: 3 Pages: 280-91

    • DOI

      10.1016/j.eplepsyres.2013.03.003

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Systematic study of the effects of stimulus parameters and stimulus location on afterdischarges elicited by electrical stimulation in the rat.2013

    • Author(s)
      Shigeto H, Boongird A, Baker K, Kellinghaus C, Najm I, Lüders H.
    • Journal Title

      Epilepsy Res

      Volume: 104 Issue: 1-2 Pages: 17-25

    • DOI

      10.1016/j.eplepsyres.2012.10.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis2012

    • Author(s)
      Isobe N, Kanamori Y, Yonekawa T, Matsushita T, Shigeto H, Kawamura N, Kira J
    • Journal Title

      J Neurol Sci

      Volume: 316(1-2) Pages: 30-5

    • Related Report
      2013 Final Research Report
  • [Journal Article] Transient vocal cord palsy caused by hypoperfusion of unilateral hemisphere2011

    • Author(s)
      Takase K, Shigeto H, Furuta K, Sakae N, Ohyagi Y, Kira J
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 102 Pages: 273-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Initial MRI findings predict progressive lacunar infarction in the territory of the lenticulostriate artery2011

    • Author(s)
      Takase K, Murai H, Tasaki R, Miyahara S, Kaneto S, Shibata M, Takashima N
    • Journal Title

      Eur Neurol

      Volume: 65 Pages: 355-60

    • Related Report
      2013 Final Research Report
  • [Journal Article] Peri-orbital electrodes as a supplemental recording for detection of ictal discharges in medial temporal lobe epilepsy2011

    • Author(s)
      Shigeto H, Sakata A, Morioka T, Takase K, Hagiwara K, Kamada T, Kanamori Y, Hashiguchi K, Tobimatsu S, Yamashita N, Kira J
    • Journal Title

      Neurology Asia

      Volume: 16 Pages: 303-307

    • Related Report
      2013 Final Research Report
  • [Presentation] 脳梗塞急性期における症候性てんかん発作の検討2014

    • Author(s)
      高瀬敬一郎, ら
    • Organizer
      第39回日本脳卒中学会総会
    • Place of Presentation
      大阪府大阪国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳梗塞急性期における症候性てんかん発作の検討.2014

    • Author(s)
      高瀬敬一郎ら
    • Organizer
      第39回日本脳卒中学会総会
    • Place of Presentation
      大阪府大阪国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 虚血性脳血管障害と抗血小板療法2013

    • Author(s)
      高瀬敬一郎
    • Organizer
      筑豊 ATIS サミット
    • Place of Presentation
      福岡県飯塚市のがみプレジデントホテル
    • Year and Date
      2013-09-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 非ヘルペス性良性辺縁系脳炎の多様性について : 当科で経験した10 症例の検討2013

    • Author(s)
      高瀬敬一郎, ら
    • Organizer
      第9回日本てんかん学会九州地方会
    • Place of Presentation
      福岡市九州大学百年講堂
    • Year and Date
      2013-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 動脈硬化症疾患予防ガイドラインに準じた脳梗塞治療2013

    • Author(s)
      高瀬敬一郎
    • Organizer
      筑豊 CREST MEETING
    • Place of Presentation
      福岡県田川市医師会館
    • Year and Date
      2013-06-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳梗塞治療における血圧管理2013

    • Author(s)
      高瀬敬一郎
    • Organizer
      慢性神経疾患外来管理勉強会
    • Place of Presentation
      福岡市九州厚生年金病院
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] よくわかる!脳梗塞2013

    • Author(s)
      高瀬敬一郎
    • Organizer
      第19回地域医療サポーター養成講座
    • Place of Presentation
      福岡県飯塚市飯塚コスモスコモン
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Prenatal Lesioning Cortical Dysplasia Rat Model with Spontaneous Temporal Lobe Seizures2013

    • Author(s)
      Kei-ichiro Takase, Takashi Kamada, Taira Uehara, Hiroshi Shigeto, Satoshi O. Suzuki, Hiroyuki Murai, Jun-ichi Kira
    • Organizer
      XXI World Congress of Neurology
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2013 Final Research Report
  • [Presentation] モデルラットを用いた実験的局所皮質異形性の形成に関する組織学的検討2013

    • Author(s)
      高瀬敬一郎, ら
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京都東京国際フォーラム
    • Related Report
      2013 Final Research Report
  • [Presentation] Prenatal Lesioning Cortical Dysplasia Rat Model with Spontaneous Temporal Lobe Seizures.2013

    • Author(s)
      Kei-ichiro Takase, Takashi Kamada, Taira Uehara, Hiroshi Shigeto, Satoshi O. Suzuki, Hiroyuki Murai, Jun-ichi Kira.
    • Organizer
      XXI World Congress of Neurology
    • Place of Presentation
      XXI World Congress of Neurology
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非ヘルペス性良性辺縁系脳炎の多様性について:当科で経験した10症例の検討.2013

    • Author(s)
      高瀬敬一郎ら
    • Organizer
      第9回日本てんかん学会九州地方会
    • Place of Presentation
      福岡市九州大学百年講堂
    • Related Report
      2013 Annual Research Report
  • [Presentation] モデルラットを用いた実験的局所皮質異形性の形成に関する組織学的検討.2013

    • Author(s)
      高瀬敬一郎ら
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京都東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] モデルラットを用いた実験的局所皮質異形成の形成に関する組織学的検討2013

    • Author(s)
      高瀬敬一郎,重藤寛史,進村光規,鎌田崇嗣,吉良潤一
    • Organizer
      日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2012 Research-status Report
  • [Presentation] てんかんとは?2012

    • Author(s)
      高瀬敬一郎
    • Organizer
      第1回筑豊てんかん市民公開講座
    • Place of Presentation
      飯塚市飯塚コスモスコモン
    • Year and Date
      2012-10-06
    • Related Report
      2013 Final Research Report
  • [Presentation] レンズ核線条体動脈支配領域の進行性ラクナ梗塞を初診時 MRI で予測する試み2012

    • Author(s)
      高瀬敬一郎, ら
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京都東京国際フォーラム
    • Related Report
      2013 Final Research Report
  • [Presentation] レンズ核線条体動脈支配領域の進行性ラクナ梗塞を初診時 MRI で予測する試み2011

    • Author(s)
      高瀬敬一郎, ら
    • Organizer
      第36回日本脳卒中学会総会
    • Place of Presentation
      京都市国立京都国際会館
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      https://www.med.kyushu-u.ac.jp/neuro/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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