Development of silk fibroin-polyurethane composite material for small diameter vascular graft
| Project/Area Number |
23500512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
NAKAZAWA Yasumoto 東京農工大学, 工学(系)研究科(研究院), 准教授 (20456255)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAKURA Tetsuo 東京農工大学, 大学院工学研究院, 教授 (30139208)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 組織工学 / ポリウレタン / 絹フィブロイン / 再生医工学 / 材料科学 / 絹 / 人工臓器工学 |
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| Outline of Final Research Achievements |
A novel tissue-engineered vascular graft composed of silk fibroin was developed by the electrospinning method. In this study, silk fibroin was combined with several functional materials such as polypeptides and polyurethane to enhance the functionality of elasticity and cellular affinity. Each vascular grafts were characterized with SEM, solid-state NMR, compressive elastic modulus and permeability. These result of solid state NMR measurement indicated that this composite material exists independently each other in molecular level. Nevertheless, it showed compatible behavior between silk fibroin and polyurethane.
Moreover, these grafts were implanted to inferior vena cava of dog. At 6 month after implantation. As a result,the histological stain evaluation revealed that the endosporium is formed on the implanted patch at 10 months after implantation.
This study will give basic information on development of new silk-like materials for tissue-engineered vascular grafts.
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Report
(5 results)
Research Products
(43 results)
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[Journal Article] Recombinant silk fibroin incorporated celladhesive sequences produced by transgenic silkworm as a possible candidate for use in vascular graft2014
Author(s)
Asakura, T., Isozaki, M., Saotome, T., Tatematsu, K., Sezutsu, H., Kuwabara, N., Nakazawa, Y.
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Journal Title
Journal of Materials Chemistry B
Volume: 2
Issue: 42
Pages: 7375-7383
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 絹を基盤とした小口径人工血管の作製と動物実験評価2013
Author(s)
中澤靖元, デリヤアイテミズ, 藤田陽子, 高木義秀, 芳賀真, 山本諭, 岡本宏之, 小材祐介, 深山俊治, 田中綾, 朝倉哲郎
Organizer
第62回高分子討論会
Place of Presentation
金沢大学（石川県金沢市）
Related Report
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