Evaluation of generation process and physiological functional mechanism of nitrate-derived nitric oxide in the vascular system
| Project/Area Number |
23500534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRAMATSU Osamu 川崎医療福祉大学, 医療技術学部, 准教授 (50208849)
ONO Junichi 川崎医療福祉大学, 医療技術学部, 講師 (50435351)
OGAWA Takehito 川崎医療福祉大学, 医療技術学部, 講師 (10454050)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 一酸化窒素（NO） / 硝酸 / 亜硝酸 / 抗酸化物質 / ポリフェノール / カテキン / 抗酸化力 / 還元物質 / 還元反応 |
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| Research Abstract |
We have focused on nitric oxide (NO) derived from nitrite, not from NO synthase. First, we confirmed NO generation from a mixture of nitrite contained in saliva and anti-oxidant contained in drinks. Next, it was found that nitrite-derived NO generation with antioxidant-containing drinks depended on the anti-oxidative capacity of these drinks. Finally, positive linear correlations were observed between nitrite-derived NO generation and anti-oxidant capacity indexes such as BAP and OXY values. Thus, we clarified the important roles of anti-oxidants in the process of nitrite-derived NO generation under acidic conditions.
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Report
(4 results)
Research Products
(17 results)
