| Project/Area Number |
23500539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Yamagata University |
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Principal Investigator |
NAKAMURA Takao 山形大学, 医学(系)研究科(研究院), 教授 (00142654)
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| Co-Investigator(Renkei-kenkyūsha) |
FENG Zhonggang 山形大学, 大学院・理工学研究科, 准教授 (10332545)
NISHINA Atsuyoshi 日本大学, 理工学部, 教授 (00469884)
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| Research Collaborator |
KUSUNOKI Masataka 愛知医科大, 医学部, 准教授 (80214956)
SATO Daisuke 山形大学, 大学院・医学系研究科, 助教 (60536960)
TSUTSUMI Kazuhiko 徳島文理大学, 薬学部, 特任教授
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 心筋細胞 / 培養 / 多価不飽和脂肪酸 / ラット / 必須脂肪酸 |
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| Research Abstract |
Fatty acid (FA) compositions in fetal, neonatal, and cultured cardiomyocytes (CMs) were evaluated and compared to each other. The results suggest that cultured CMs have considerably lower amount of polyunsaturated FAs (PUFAs) than neonatal ones do. Thus, we added some PUFAs, which were combined with albumin, into medium, and found that FAs were successfully incorporated in CMs, that FA elongation may have taken place, and that the beating performance was tripled. In the next stage, FAs to add should be optimized to gain the best mechanical performance.
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