| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Research Abstract |
Magnetic resonance elastography (MRE) is a technique for quantitative evaluation of the viscoelasticity of tissue. In most MRE studies an external driver is used to generate waves within tissue. It has been demonstrated that the vibrations of the patient bed that result from the impulse of an imaging gradient lobe can be used as a mechanical driving mechanism for MRE. The method is limited by the low amplitude of the vibrations. Consequently, it is difficult to measure high-resolution storage modulus maps (elastograms) that are able to sufficiently resolve small in vivo tissue structure. In this study, we propose a way to improve this method by using switching-gradient induced vibration in conjunction with a conventional MRE pulse sequence. Sufficient vibration amplitude was available when the switching-gradient induced vibration frequency was optimized. The results indicate that proposed system may enable quantitative measurement of viscoelasticity.
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