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Development of minimally invasive ablation treatment system of tongue cancer using an AC magnetic field

Research Project

Project/Area Number 23500559
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionEhime University

Principal Investigator

NAOHARA TAKASHI  愛媛大学, 理工学研究科, 准教授 (50093935)

Co-Investigator(Kenkyū-buntansha) WATANABE Yuji  愛媛大学, 大学院・医学系研究科, 教授 (20210958)
MAEHARA Tsunehiro  愛媛大学, 大学院・理工学研究科, 教授 (40274302)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords癌治療 / 焼灼療法 / 交流磁場誘導法 / チタン被覆磁性体針 / 生体等価ファントム / 磁界解析シミュレーション / 熱伝達シミュレーション / 焼灼用磁性体針 / ハイパーサーミア / 発熱シミュレーション / 動物実験
Research Abstract

To develop a novel ablation treatment system of tongue cancer, the heating properties of a prototype Ti-coated needle with a 26.5mm length were investigated in an AC magnetic field. The effect of the inclination angle was completely eliminated in the newly designed needle, suggesting that the non-oriented heating property relative to the magnetic flux direction allows the precise control of the ablation temperature. In the magnetic field analysis, simulation images of the current density and Joule loss density were obtained for the prototype Ti-coated ablation needle. Moreover, the heat transfer behavior was simulated for the tissue-mimicking phantom subjected to the insertion of the prototype Ti-coated ablation needle in order to visualize their temperature distribution.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Remarks (2 results)

  • [Journal Article] Heat Transfer Behavior of Ti-coated Carbon Steel Rod for Ablation Therapy of Tongue Cancer Utilizing High-frequency Induction Technique2013

    • Author(s)
      T. Naohara, H. Aono, T. Maehara, H. Hirazawa, S. Matsutomo, Y. Watanabe
    • Journal Title

      Proceedings of The International Conference on Heating by Electromagnetic Sources

      Pages: 153-157

    • Related Report
      2013 Final Research Report
  • [Journal Article] Heat Generation and Transfer Behaviors of Ti-Coated Carbon Steel Rod Adaptable for Ablation Therapy of Oral Cancer2013

    • Author(s)
      T. Naohara, H. Aono, T. Maehara, H. Hirazawa, S. Matsutomo, Y. Watanabe
    • Journal Title

      Journal of Functional Biomaterials

      Volume: Vol. 4 Pages: 27-37

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-frequency induction heating of Ti-coated mild steel rod for minimally invasive ablation therapy of human cancer2013

    • Author(s)
      T. Naohara, H. Aono, K. Shirai, T. Maehara, H. Hirazawa, S. Matsutomo, Y. Watanabe
    • Journal Title

      Journal of Magnetism and Magnetic Materials

      Volume: Vol. 331 Pages: 168-173

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat Transfer Behavior of Ti-coated Carbon Steel Rod for Ablation Therapy of Tongue Cancer Utilizing High-frequency Induction Technique2013

    • Author(s)
      T. Naohara 他5名
    • Journal Title

      Proceedings of The International Conference on Heating by Electromagnetic Sources (HES-13)

      Volume: - Pages: 153-157

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Heat Generation and Transfer Behaviors of Ti-Coated Carbon Steel Rod Adaptable for Ablation Therapy of Oral Cancer2013

    • Author(s)
      T. Naohara 他5名
    • Journal Title

      Journal of Functional Biomaterials

      Volume: 4 Pages: 27-37

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-frequency induction heating of Ti-coated mild steel rod for miniimally invasive ablation therapy of human cancer2013

    • Author(s)
      T. Naohara 他6名
    • Journal Title

      Journal of Magnetism and Magnetic Materials

      Volume: 331 Pages: 168-173

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-Frequency Induction Heating of Needle-Shaped Mg-Ferrite for Ablation Therapy of Human Cancer2012

    • Author(s)
      T. Naohara, H. Aono, T. Maehara, H. Hirazawa, S. Matsutomo, Y. Watanabe
    • Journal Title

      Journal of Iron and Steel Research, International

      Volume: Vol.19 Pages: 735-738

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of Ti-Coated Ferromagnetic Needle, Adaptable for Ablation Cancer Therapy by High-Frequency Induction Heating2012

    • Author(s)
      T. Naohara, H. Aono, T. Maehara, H. Hirazawa, S. Matsutomo, Y. Watanabe
    • Journal Title

      Journal of Functional Biomaterials

      Volume: Vol. 3 Pages: 163-172

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor local chemohyperthermia using docetaxel-embedded magnetoliposomes : Interaction of chemotherapy and hyperthermia2012

    • Author(s)
      M. Yoshida, M. Sato, Y. Yamamoto, T. Maehara, T. Naohara, H. Aono, H. Sugishita, K. Sato, Y. Watanabe
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: Vol. 27 Pages: 406-411

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-Frequency Induction Heating of Needle-Shaped Mg-Ferrite for Ablation Therapy of Human Cancer2012

    • Author(s)
      T.Naohara 他5名
    • Journal Title

      Journal of Iron and Steel Research, International

      Volume: 19 (Suppl. 1) Pages: 735-738

    • Related Report
      2012 Research-status Report
  • [Journal Article] Development of Ti-Coated Ferromagnetic Needle, Adaptable for Ablation Cancer Therapy by High-Frequency Induction Heating2012

    • Author(s)
      T. Naohara  他5名
    • Journal Title

      Journal of Functional Biomaterials

      Volume: 3 Pages: 163-172

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor local chemohyperthermia using docetaxel-embedded magnetoliposomes: Interaction of chemotherapy and hyperthermia2012

    • Author(s)
      Y. Yoshida 他8名
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 27 Pages: 406-411

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Heat Transfer Behavior of Ti-coated Carbon Steel Rod for Ablation Therapy of Tongue Cancer Utilizing High-frequency Induction Technique2013

    • Author(s)
      T. Naohara, H. Aono, T. Maehara, H. Hirazawa, S. Matsutomo, Y. Watanabe
    • Organizer
      International Conference on Heating by Electromagnetic Sources(HES13)
    • Place of Presentation
      パドヴァ(イタリア)
    • Year and Date
      2013-05-22
    • Related Report
      2013 Final Research Report
  • [Presentation] High-Frequency Induction Heating of Needle-Shaped Mg-Ferrite for Ablation Therapy of Human Cancer2012

    • Author(s)
      T. Naohara, H. Aono, T. Maehara, H. Hirazawa, S. Matsutomo, Y. Watanabe
    • Organizer
      The 7th International Conference on Electromagnetic Processing of Materials (EPM2012)
    • Place of Presentation
      北京(中華人民共和国)
    • Year and Date
      2012-10-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Ti を被覆した炭素鋼丸棒の生体等価ファントム中での高周波誘導発熱特性2012

    • Author(s)
      樋口貴文, 猶原隆, 青野宏通, 前原常弘, 渡部祐司, 平澤英之, 松友真哉
    • Organizer
      日本金属学会第150回春期講演大会
    • Place of Presentation
      横浜国立大学(横浜市)
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 癌の高周波誘導焼灼療法に用いるチタン被覆磁性体針の発熱特性2011

    • Author(s)
      猶原隆, 青野宏通, 前原常弘, 渡部祐司, 平澤英之, 松友真哉
    • Organizer
      日本金属学会第149回秋期講演大会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Year and Date
      2011-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Heat Transfer Behavior of Ti-coated Carbon Steel Rod for Ablation Therapy of Tongue Cancer Utilizing High-frequency Induction Technique

    • Author(s)
      T. Naohara 他5名
    • Organizer
      International Conference on Heating by Electromagnetic Sources (HES-13)
    • Place of Presentation
      イタリア(パドヴァ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] High-frequency induction heating of needle-shaped Mg-ferrite for ablation therapy of human cancer

    • Author(s)
      T.Naohara 他5名
    • Organizer
      The 7th International Conference on Electromagnetic Processing of Materials (EPM2012)
    • Place of Presentation
      中華人民共和国(北京)
    • Related Report
      2012 Research-status Report
  • [Presentation] Tiを被覆した炭素鋼丸棒の生体等価ファントム中での高周波誘導発熱特性

    • Author(s)
      樋口 貴文 他6名
    • Organizer
      日本金属学会・2012年春期(第150回)大会
    • Place of Presentation
      横浜国立大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 癌の高周波誘導焼灼療法に用いるチタン被覆磁性体針の発熱特性

    • Author(s)
      猶原 隆 他5名
    • Organizer
      日本金属学会・2011年秋期(第149回)大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.naohara-lab.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] 愛媛大学工学部 機能材料工学科 組織制御学研究室

    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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