|Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Aim of this study is to develop minimally invasive strategy for preventing in-stent restenosis of peripheral arterial disease.
The generation of heat was obtained by magnetic field irradiation to a nickel-titanium alloy (nitinol) stent at 200kHz or 900kHz/4mT in in vitro, but we could not reach to the stage of animal experiments due to construction of magnetic field generator. The generation of the free radicals was observed by ultrasound irradiation to a nitinol stent at 500kHz or 1MHz. Free radicals were effective to suppress the in-stent stenosis on xenograft model (subcutaneous tumor model). WHHLMI rabbit exhibits hereditary hyperlipidemia and arteriosclerosis. In the rabbit intimal thickening model, the main artery of the WHHLMI rabbit rubbed with Fogarty catheter, and then, nitinol stent was inserted after two weeks from the treatment. There was no restenosis after one month from insersion, thereby the model was extended up to six months and are currently being analyzed.