| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
Recently, some drug and gene therapies for brain disorder have been developed. However, many drugs and genes dropped off from clinical candidates in animal and clinical phase studies because of low efficiency of brain delivery. Therefore, it is necessary to develop effective and non-invasive drug and gene delivery system. To improve this, I developed a novel gene delivery system into brain by the combination of nanobubbles and ultrasound. Our delivery system is the combination of systemic injection of nanobubbles and plasmid DNA and trans-scalp ultrasound exposure to brain. It could express reporter gene in the brain. Therefore, this ultrasound delivery system would be a minimally invasive and brain-selective gene delivery system.
|
