Development of the new sonodynamic cancer therapy combined with nano or micro technology
| Project/Area Number |
23500569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Yokohama College of Pharmacy |
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Principal Investigator |
IWASE Yumiko 横浜薬科大学, 薬学部, 講師 (00521882)
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| Co-Investigator(Kenkyū-buntansha) |
UMEMURA Shin-ichirou 東北大学, 工学部, 教授 (20402787)
YUMITA Nagahiko 横浜薬科大学, 薬学部, 教授 (40191481)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アポトーシス / ドラッグデリバリーシステム / ナノ粒子 / マイクロ微粒子 / 超音波 / 音響化学療法 / ナノ微粒子 |
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| Research Abstract |
In this study, we investigated the sonodynamically induced antitumor effect of functionalized fullerenes. The antitumor effects of functionalized fullerenes in combination with ultrasound at 2 MHz were screened. The ultrasonically induced damage on isolated sarcoma 180 cells was enhanced significantly with polyhydroxy fullerenes (PHF) or pyrrolidine tris-acid fullerenes (PTF). In the experimental treatment, the combined with ultrasonic exposure and PHF inhibited the growth of the inoculated colon 26 tumors. The significant reduction by histidine of ultrasonically induced cell damage enhanced by PHF suggests that the enhancement was due to sonodynamic generation of active oxygen such as singlet oxygen by functionalized fullerenes. The involvement of singlet oxygen was also confirmed by ESR spectometory. These results support the possibility of clinical application of sonodynamic treatment using water soluble functionalized fullerene.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Involvement of Reactive Oxygen Species in Sonodynamically Induced Apoptosis Using a Novel Porphyrin Derivative2012
Author(s)
Nagahiko Yumita, Yumiko Iwase, Koji Nishi, Hajime Komatsu, Kazuyoshi Takeda, Kenji Onodera, Toshio Fukai, Toshihiko Ikeda, Shin-ichiro Umemura, Kazuho Okudaira, Yasunori Momose
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Journal Title
Theranostics
Volume: 2
Issue: 9
Pages: 880-888
DOI
Related Report
Peer Reviewed
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[Journal Article] Sonodynamically-induced antitumor effect of mono-l-aspartyl chlorin e6 (NPe6)2011
Author(s)
Yumita N, Iwase Y, Nishi K, Ikeda T, Komatsu H, Fukai T, Onodera K, Nishi H, Takeda K, Umemura S, Okudaira K, Momose Y
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Journal Title
Anticancer Res
Volume: 31
Pages: 501-6
Related Report
Peer Reviewed
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[Journal Article] Sonodynamically-induced antitumor effect of mono-l-aspartyl chlorin e6 (NPe6)2011
Author(s)
N. Yumita, Y. Iwase, K. Nishi, T. Ikeda, H. Komatsu, T. Fukai, K. Onodera, H. Nishi, K. Takeda, S. Umemura, K. Okudaira and Y. Momose
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Journal Title
Anticancer Res.
Volume: 31
Pages: 501-506
Related Report
Peer Reviewed
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