Development of Diagnosis Device for Alzheimer's Disease Using Amyloid beta Fibrillization Promoting Peptide
Project/Area Number |
23500571
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical systems
|
Research Institution | Konan University |
Principal Investigator |
FUJII SATOSHI 甲南大学, フロンティアサイエンス学部, 教授 (80271518)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
Keywords | アルツハイマー型認知症 / アミロイドβ / プロテインチップ / 電気化学 / センサー / 水晶振動子マイクロバランス法 / バイオマーカー / 診断システム / アルツハイマー病 / 水晶振動子マイクロバランス / アミロイドβペプチド / 診断装置 |
Outline of Final Research Achievements |
Amyloid beta peptide (A beta) is a potential biomarker to evaluate the risk of Alzheimer's disease. Our purpose in this study was to develop a preclinical diagnostic device for Alzheimer's disease with ultra high sensitivity, ease, and high-through put, and at low cost. Using an A beta aggregation promoting peptide which was developed by us, we can detect ~10 nM of A beta quantitatively within 1 hour. We are now trying to improve the sensitivity to detect plasma A beta and put it to practical use.
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Report
(4 results)
Research Products
(9 results)