Tissue characterization of unstable coronary plaque using IB signal and coronary CT

• Project/Area Number: 23500572
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Kawasaki Medical School
• Principal Investigator: KAWAMOTO Takahiro 川崎医科大学, 医学部, 講師 (30368667)
• Co-Investigator(Kenkyū-buntansha): NEISHI Yoji 川崎医科大学, 医学部, 講師 (80319946) ; OKURA Hiroyuki 川崎医科大学, 医学部, 准教授 (30425136) ; YOSHIDA Kiyoshi 川崎医科大学, 医学部, 教授 (60322583)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 冠動脈CT / 虚血性心疾患

Research Abstract

We analyzed 20 cases with acute coronary syndrome using intravascular ultrasound and IB signal analysis. The characteristics of unstable coronary plaque were identified by this analysis. Then 25 cases with angina pectoris who underwent both of coronary CT and coronary angiography were included next study. We analyzed 59 lesions showing more than 50% diameter stenosis on coronary CT and classified into 4 types of lesions; calcified, non-calcified, mixed, and non-plaque. Overall positive predictive value was 64% and we revealed that it was not same at each 4 types of lesion character; 33.3% of calcified, 91.7% of non-calcified, 50% of mixed, and 56.2% of non-plaque lesion.

Research Products

• [Journal Article] A unique feature of thin flat thrombus visualised by optical coherence tomography (2013)
  • Author(s): Kume T, Okura H, Fukuhara K, Koyama T, Nezuo S, Neishi Y, Hayashida A, Kawamoto T, Yoshida K
  • Journal Title: EuroIntervention Volume: 9(8) Pages: 1008-1008
  • Peer Reviewed
• [Journal Article] Visualization of coronary plaque vasa vasorum by intravascular ultrasound (2013)
  • Author(s): Kume T, Okura H, Fukuhara K, Koyama T, Yamada R, Neishi Y, Hayashida A, Kawamoto T, Yoshida K
  • Journal Title: JACC Cardiovasc Interv Volume: 6(9) Pages: 985-985
  • Peer Reviewed
• [Journal Article] Natural history of stent edge dissection, tissue protrusion and incomplete stent apposition detectable only on optical coherence tomography after stent implantation - preliminary observation - (2012)
  • Author(s): Kume T, Okura H, Miyamoto Y, Yamada R, Saito K, Tamada T, Koyama T, Neishi Y, Hayashida A, Kawamoto T, Yoshida K
  • Journal Title: Circ J Volume: 76(3) Pages: 698-703
  • NAID: 10030130249
  • Peer Reviewed
• [Journal Article] Plaque characteristics of thin-cap fibroatheroma evaluated by OCT and IVUS (2011)
  • Author(s): Miyamoto Y, Okura H, Kume T, Kawamoto T, Neishi Y, Hayashida A, Yamada R, Imai K, Saito K, Yoshida K
  • Journal Title: JACC Cardiovasc Imaging Volume: 4(6) Pages: 638-46
  • Peer Reviewed
• [Presentation] 心不全患者におけるトルバプタン新規投与時の利尿効果と併用薬の関係 (2013)
  • Author(s): 川元隆弘, 大倉宏之, 根石陽二, 林田晃寛, 久米輝善, 尾長谷喜久子, 今井孝一郎, 鼠尾晋太郎, 玉田智子, 古山輝將, 吉田清
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航熊本(熊本)
  • Year and Date: 2013-09-21
• [Presentation] 心臓CTでの冠動脈狭窄診断に及ぼす冠動脈プラーク性状の影響 (2013)
  • Author(s): 比嘉冨貴, 大倉宏之, 根石陽二, 林田晃寛, 久米輝善, 尾長谷喜久子, 今井孝一郎, 鼠尾晋太郎, 玉田智子, 古山輝將, 川元隆弘, 吉田清
  • Organizer: 第23回日本心血管画像動態学
  • Place of Presentation: 東京ステーションコンファレンス(東京)
  • Year and Date: 2013-01-25
• [Presentation] 心臓CTでの冠動脈狭窄診断に及ぼす冠動脈プラーク性状の影響 (2013)
  • Author(s): 比嘉 富貴
  • Organizer: 日本心血管画像動態学会
  • Place of Presentation: 東京ステーションコンファレンス（東京）
• [Presentation] 心不全患者におけるトルバプタン新規投与時の利尿効果と併用薬の関係
  • Author(s): 川元 隆弘
  • Organizer: 日本心臓病学会
  • Place of Presentation: ホテル日航熊本（熊本）