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Development of functional brain machine interface for gait disturbance after stroke

Research Project

Project/Area Number 23500576
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTohoku University

Principal Investigator

TAKEUCHI Naoyuki  東北大学, 大学病院, 助教 (10374498)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsリハビリテーション / ブレイン・マシンインターフェイス / 脳卒中 / 神経科学
Research Abstract

Simultaneous transcranial magnetic stimulation (tDCS) and functional electrical stimulation for tibial nerve could induce no improvement of gait disturbance in stroke patients. In order to apply brain-machine interface (BMI) to therapy of gait disturbance, we investigated whether tDCS could modulate sensorimotor rhythm (SMR) control, which utilized for BMI. The responses of SMR after tDCS were different between healthy subjects and patients with lower limb amputations. It is necessary for application of BMI technique in gait disturbance to use inhibitory or excitatory stimulation properly. These findings might contribute in improving the effectiveness of SMR-based BMI for gait restoration.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 10 results) Presentation (11 results) Remarks (4 results)

  • [Journal Article] 経頭蓋磁気刺激を用いた脳卒中後運動麻痺の可塑性評価および治療2014

    • Author(s)
      竹内直行
    • Journal Title

      神経内科

      Volume: 80巻 Pages: 347-355

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Rehabilitation with poststroke motor recovery: a review with a focus on neural plasticity.2013

    • Author(s)
      Takeuchi N, Izumi S.
    • Journal Title

      Stroke Res Treat.

      Volume: 2013 Pages: 128641-128641

    • DOI

      10.1155/2013/128641

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳可塑性がもたらすリハビリテーション医学へのインパクト脳卒中後運動麻痺に対する非侵襲的脳刺激2013

    • Author(s)
      竹内直行, 出江紳一
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 50巻 Pages: 723-731

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 電気生理検査による機能障害の評価 脳卒中後運動麻痺と経頭蓋磁気刺激2013

    • Author(s)
      竹内直行, 出江紳一
    • Journal Title

      Journal of Clinical Rehabilitation

      Volume: 22巻 Pages: 1020-1027

    • Related Report
      2013 Final Research Report
  • [Journal Article] World J Neurol2013

    • Author(s)
      Isoyama H, Takeuchi N.
    • Journal Title

      Overview of botulinum toxin as a treatment for spasticity in stroke patients

      Volume: 3 Issue: 4 Pages: 133-137

    • DOI

      10.5316/wjn.v3.i4.133

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳可塑性がもたらすリハビリテーション医学へのインパクト 脳卒中後運動麻痺に対する非侵襲的脳刺激2013

    • Author(s)
      竹内 直行, 出江 紳一
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 50 Pages: 723-731

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 電気生理検査による機能障害の評価 脳卒中後運動麻痺と経頭蓋磁気刺激2013

    • Author(s)
      竹内 直行, 出江 紳一
    • Journal Title

      Journal of Clinical Rehabilitation

      Volume: 22 Pages: 1020-1027

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Motor control and neural plasticity through interhemispheric interactions.2012

    • Author(s)
      Takeuchi N, Oouchida Y, Izumi S.
    • Journal Title

      Neural Plast.

      Volume: 2012 Pages: 823285-823285

    • DOI

      10.1155/2012/823285

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noninvasive brain stimulation for motor recovery after stroke: mechanisms and future views.2012

    • Author(s)
      Takeuchi N, Izumi S.
    • Journal Title

      Stroke Res Treat.

      Volume: 2012 Pages: 584727-584727

    • DOI

      10.1155/2012/584727

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maladaptive plasticity for motor recovery after stroke: mechanisms and approaches.2012

    • Author(s)
      Takeuchi N, Izumi S.
    • Journal Title

      Neural Plast.

      Volume: 2012 Pages: 359728-359728

    • DOI

      10.1155/2012/359728

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low-Frequency Repetitive TMS Plus Anodal Transcranial DCS Prevents Transient Decline in Bimanual Movement Induced by Contralesional Inhibitory rTMS After Stroke2012

    • Author(s)
      Takeuchi N, Tada T, Matsuo Y, Ikoma K
    • Journal Title

      Neurorehabil Neural Repair

      Volume: 26 Issue: 8 Pages: 988-998

    • DOI

      10.1177/1545968311433295

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大脳皮質刺激によるニューロリハビリテーション : 磁気刺激, 電気刺激2012

    • Author(s)
      竹内直行, 出江紳一
    • Journal Title

      MB Med Reha

      Volume: 141 Pages: 5-13

    • Related Report
      2013 Final Research Report
  • [Journal Article] Low-Frequency Repetitive TMS Plus Anodal ...2012

    • Author(s)
      Takeuchi N et al.
    • Journal Title

      Neurorehabil Neural Repair.

      Volume: In press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 大脳皮質刺激によるニューロリハビリテーション:磁気刺激、電気刺激2012

    • Author(s)
      竹内直行, 出江紳一
    • Journal Title

      MB Med Reha

      Volume: 141 Pages: 5-13

    • Related Report
      2011 Research-status Report
  • [Journal Article] Low frequency repetitive transcranial magnetic stimulation over unaffected motor cortex in stroke patients influences bilateral movement and coupling between motor related cortices2011

    • Author(s)
      Takeuchi N, Ikoma K
    • Journal Title

      Jpn J Rehabil Med

      Volume: 48 Pages: 341-351

    • NAID

      130000814538

    • Related Report
      2013 Final Research Report
  • [Journal Article] Low frequency repetitive transcranial magnetic s2011

    • Author(s)
      Takeuchi N et al.
    • Journal Title

      Jpn J Rehabil Med

      Volume: 48 Pages: 341-351

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 下肢切断患者における足運動イメージ感覚運動リズム2014

    • Author(s)
      竹内直行, 森隆行, 西嶋一智, 近藤健男, 出江紳一
    • Organizer
      第33回日本リハビリテーション医学会東北地方会
    • Place of Presentation
      名取
    • Year and Date
      2014-03-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 下肢切断患者における足運動イメージ感覚運動リズム2014

    • Author(s)
      竹内直行、森隆行、西嶋一智、近藤健男、出江紳一
    • Organizer
      第35回日本リハビリテーション医学会 東北地方会
    • Place of Presentation
      名取市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非侵襲的脳刺激を用いたリハビリテーションへの応用2012

    • Author(s)
      竹内直行, 出江紳一
    • Organizer
      第7回日本リハビリテーション医学会専門医会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-11-18
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 脳卒中機能回復に向けた神経生理学的評価の展開 経頭蓋磁気刺激を用いた脳卒中後可塑性評価2012

    • Author(s)
      竹内直行, 出江紳一
    • Organizer
      第42回日本臨床神経生理学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Coordination of bimanual movement after stroke dependents on interhemispheric inhibition and motor impairment2012

    • Author(s)
      Takeuchi N. Izumi SI
    • Organizer
      Asia Pacific Stroke Conference 2012
    • Place of Presentation
      東京
    • Year and Date
      2012-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳卒中機能回復に向けた神経生理学的評価の展開 経頭蓋磁気刺激を用いた脳卒中後可塑性評価2012

    • Author(s)
      竹内直行, 出江紳一
    • Organizer
      第42回 日本臨床神経生理学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Coordination of bimanual movement after stroke dependents on interhemispheric inhibition and motor impairment.2012

    • Author(s)
      Takeuchi N. Izumi SI.
    • Organizer
      Asia Pacific Stroke Conference 2012
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] 脳卒中後運動麻痺に対する経頭蓋磁気刺激治療2011

    • Author(s)
      竹内直行, 出江紳一
    • Organizer
      第14回日本栓子検出と治療学会
    • Place of Presentation
      仙台
    • Year and Date
      2011-11-19
    • Related Report
      2013 Final Research Report
  • [Presentation] TMS の臨床応用 脳卒中リハビリテーションへの応用2011

    • Author(s)
      竹内直行, 出江紳一
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      静岡
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] TMSの臨床応用 脳卒中リハビリテーションへの応用

    • Author(s)
      竹内直行, 出江紳一
    • Organizer
      第41回 日本臨床神経生理学会学術大会
    • Place of Presentation
      静岡
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳卒中後運動麻痺に対する経頭蓋磁気刺激治療

    • Author(s)
      竹内直行, 出江紳一
    • Organizer
      第14回 日本栓子検出と治療学会
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.reha.med.tohoku.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 東北大学病院 肢体不自由学分野

    • URL

      http://www.reha.med.tohoku.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 肢体不自由学分野

    • URL

      http://www.reha.med.tohoku.ac.jp/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.reha.med.tohoku.ac.jp/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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