Plasticity of central nervous system after intercostal-musculocutaneous nerve transfer

• Project/Area Number: 23500601
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Ibaraki Prefectural University of Health Science
• Principal Investigator: SASAKI Sei-Ichi 茨城県立医療大学, 保健医療学部, 教授 (50153987)
• Co-Investigator(Kenkyū-buntansha): IIZUKA Makito 昭和大学, 医学部, 助教 (40274980)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 肋間神経移行 / 中枢神経系 / 可塑性 / 霊長類 / 呼吸 / 大脳皮質 / 運動野 / 随意運動

Outline of Final Research Achievements

Intercostal-musculocutaneous nerve transfer has been applied to clinical cases of severe brachial plexus injury. After 1 to 2 years, patients can move their injured elbow voluntarily. However, neural mechanisms of have not been fully examined. We examined function recovery of the biceps brachii muscle after T 3 and T4 internal intercostal nerves were transferred to the musculocutaneous nerve in monkey.　Afte r 10 months survival period, IC-biceps showed voluntary movements and activities were separated from T5 intercostal muscle activities. However, IC-biceps showed very weak respiratory activities. These results indicate that Th3 and Th4 intercostal motoneurons lose some of respiratory descending inputs and may receive the newly synaptic inputs associated voluntary movements from the cortex or the brainstem.

Research Products

• [Journal Article] 糖尿病による錘内筋線維の変性 (2013)
  • Author(s): 村松憲、丹羽正利、石黒友康、長谷川達也、佐々木誠一
  • Journal Title: 運動障害 Volume: 23 Pages: 81-89
  • Peer Reviewed
• [Journal Article] 末梢神経障害によって生じる運動ニューロンの形態変化 (2013)
  • Author(s): 芦川聡宏、村松憲、斉藤利恵、石黒友康、佐々木誠一、丹羽正利
  • Journal Title: 運動障害 Volume: 23 Pages: 85-89
  • Peer Reviewed
• [Journal Article] The size of motoneurons of the gastrocnemius muscle in rats with diabetes (2012)
  • Author(s): Muramatsu K,Niwa M,Nagai M,Kamimura T,Sasaki S-I, Ishiguro T
  • Journal Title: Neuroscience Letters Volume: 531 Issue: 2 Pages: 109-113
  • DOI: 10.1016/j.neulet.2012.10.031
  • Peer Reviewed
• [Presentation] 運動から脳へのアプローチ (2015)
  • Author(s): 佐々木誠一
  • Organizer: ぎふ技術革新センター運営協議会 公開講演会
  • Place of Presentation: 岐阜市じゅうろくプラザ
  • Year and Date: 2015-03-14
  • Invited
• [Presentation] 生体信号記録のための極細線の試作開発研究 (2015)
  • Author(s): 佐々木誠一
  • Organizer: 三大学交流セミナー
  • Place of Presentation: 茨城大学
  • Year and Date: 2015-02-16
• [Presentation] 医学研究・生物科学研究における極細線記録線の試作開発 (2015)
  • Author(s): 佐々木誠一
  • Organizer: SATテクノロジーショーケース
  • Place of Presentation: つくば市つくば国際会議場
  • Year and Date: 2015-01-21
• [Presentation] 生体信号記録のための極細線の試作開発研究 (2014)
  • Author(s): 佐々木誠一
  • Organizer: 看護理工学会学術集会
  • Place of Presentation: 大阪大学豊中キャンパス
  • Year and Date: 2014-10-04 – 2014-10-05
• [Presentation] Firing properties of medullary expiratory neurons during defecation (2014)
  • Author(s): Sasaki S.-I, Niwa M
  • Organizer: 第91回日本生理学会
  • Place of Presentation: 鹿児島
• [Presentation] The property of Ia excitation and recurrent inhibition of abdominal motoneurons (2014)
  • Author(s): Niwa M, Sasaki S.-I
  • Organizer: 第91回日本生理学会
  • Place of Presentation: 鹿児島
• [Presentation] Diabetic polyneuropathy targets gamma motoneurons of the distal muscle of hindlimb in STS rats (2013)
  • Author(s): Muramatsu K, Niwa M, Ishiguro T, Hasegawa T, Sasaki S.-I
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Activities of biceps muscle after intercostal nerve transfer (2013)
  • Author(s): Sasaki S-I,Sasaki S,Uga M,Kinugasa T,Niwa M
  • Organizer: The 90th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo
• [Presentation] Diabetic polyneuropathy targets gamma motoneurons of the gastrocnemius muscle in STZ rats (2013)
  • Author(s): Muramatsu K,Niwa M,Nagai M,Kamimura T,Sasaki S-I, Ishiguro T
  • Organizer: The 90th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo
• [Presentation] Sustained hyperglycemia decreases the volume of motor nuckeus of medial gastrocnemius (2012)
  • Author(s): Muramatsu K,Ishiguro T,Niwa M,Kamimura T,Nagai M,Sasaki S-I
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya
• [Presentation] Activity patterns of respiratory neurons during defecation (2012)
  • Author(s): Sasaki S-I, Sasaki K, Niwa M
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya
• [Presentation] 糖尿病によってγ運動ニューロンが選択的に減少する
  • Author(s): 村松憲、丹羽正利、長谷川達也、佐々木誠一、石黒友康
  • Organizer: 第48回日本理学療法士学術大会
  • Place of Presentation: 名古屋
• [Presentation] 呼吸の運動制御
  • Author(s): 佐々木誠一
  • Organizer: 第9回霊長類医科学フォーラム
  • Place of Presentation: つくば
  • Invited
• [Presentation] 2型糖尿病モデルラットのγ運動ニューロンが減少する
  • Author(s): 丹羽正利、升祐二郎、玉木徹、長谷川達也、佐々木誠一
  • Organizer: 第47回日本運動障害研究会
  • Place of Presentation: 東京