| Project/Area Number |
23500612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NODA Chiharu 北里大学, 医学部, 助教 (80365080)
OGURA Misao 北里大学, 医療衛生学部, 助教 (10337991)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心臓 / リハビリテーション / 自律神経活動 / 多疾患有病者 / 運動療法 / 心臓リハビリテーション / 高齢者 / 身体機能 / 下肢筋力 / 社会福祉サービス / 身体活動 |
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| Research Abstract |
Increased insulin resistance is closely correlated with exercise capacity in patients with hypertension (HT) and/or dyslipidemia (DL), because it is known to impair the energy metabolism in skeletal muscles. The aim of this study was to investigate the influence of insulin resistance on exercise capacity in patients with HT and/or DL.
Homeostasis model assessment ratio (HOMA-R) was assessed and oxygen uptake (VO2) at anaerobic threshold (VO2 AT) and peak VO2 were measured by cardiopulmonary exercise testing. The exercise capacity was assessed using ratios of measured VO2 to predicted VO2 AT and predicted peak VO2 (%VO2 AT and %peak VO2, respectively).
The %VO2 AT and %peak VO2 were significantly lower in the high HOMA-R group than in the low HOMA-R group (P<0.05, respectively), and negatively correlated with HOMA-R (r=0.339, P<0.05 and r=0.522, P<0.05, respectively). The present study showed that increased insulin resistance decreased exercise capacity in patients with HT and/or DL.
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