Effects of daily physical activity with bone mass in hemodialysis patients

• Project/Area Number: 23500614
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kitasato University
• Principal Investigator: MATSUNAGA Atsuhiko 北里大学, 医療衛生学部, 教授 (00286387)
• Co-Investigator(Kenkyū-buntansha): WATANABE Hiroyuki 北里大学, 医療衛生学部, 講師 (40348602) ; KIMURA Masahiko 北里大学, 医療衛生学部, 講師 (20458748) ; KITAGAWA Jun 北里大学, 一般教育部, 准教授 (80260529)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: リハビリテーション / 骨量 / 身体活動 / 慢性腎臓病 / 血液透析 / 運動療法 / 骨密度 / 身体活動量

Research Abstract

Purpose: This study aimed to determine whether daily physical activity is associated with bone mass in hemodialysis (HD) patients. Methods: In cross-sectional Study 1, 150 HD outpatients undergoing maintenance HD 3 times a week were recruited. Clinical characteristics and biochemical parameters were measured. Bone mass was assessed by quantitative ultrasound measurement at the calcaneus. Physical activity (steps) was measured using an accelerometer. In 2-year follow-up Study 2, participants were divided into two subgroups according to physical activity based on results from Study 1 (more than 5,000 steps per day or not). Results: Adjusted multiple regression analysis in Study 1 indicated that physical activity was significantly associated with bone mass for each sex. ANOVA showed that changes in bone mass were significantly different between the two subgroups for each sex in Study 2. Conclusion: Decreased daily physical activity is strongly associated with bone loss in HD patients.

Research Products

• [Journal Article] Relationship between lower extremity muscle strength and all-cause mortality in Japanese patients undergoing dialysis (2014)
  • Author(s): Matsuzawa R, Matsunaga A, Wang G, Yamamoto S, Kutsuna T, Ishii A, Abe Y, Yoneki K, Yoshida A, Takahira N
  • Journal Title: Physical therapy Volume: (in press)
  • Peer Reviewed
• [Journal Article] Relationship between lower extremity muscle strength and all-cause mortality in Japanese patients undergoing dialysis (2014)
  • Author(s): Matsuzawa R, Matsunaga A, Guoqin Wang G, Yamamoto S, Kutsuna T, Ishii A, Abe Y, Yoneki K, Yoshida A, Takahira N
  • Journal Title: Physical Therapy Volume: 印刷中 Issue: 7 Pages: 947-956
  • DOI: 10.2522/ptj.20130270
  • Peer Reviewed
• [Journal Article] Quadriceps isometric strength as a predictor of exercise capacity in coronary artery disease patients (2014)
  • Author(s): Kamiya K, Mezzani A, Hotta K, Shimizu R, Kamekawa D, Noda C, Yamaoka-Tojo M, Matsunaga A, Masuda T.
  • Journal Title: European Journal of Preventive Cardiology Volume: 印刷中 Issue: 10 Pages: 1285-1291
  • DOI: 10.1177/2047487313492252
  • Peer Reviewed
• [Journal Article] Association of habitual physical activity measured by an accelerometer with high-density lipoprotein cholesterol level in maintenance hemodialysis patients (2013)
  • Author(s): Matsuzawa R, Matsunaga A, Kutsuna T, Ishii A, Abe Y, Yoneki K, Harada M, Takeuchi Y, Yoshida A, Takahira N
  • Journal Title: The Scientific World Journal Pages: 1-6
  • Peer Reviewed
• [Journal Article] Association of habitual physical activity measured by an accelerometer with high-density lipoprotein cholesterol levels in maintenance hemodialysis patients (2013)
  • Author(s): Matsuzawa R, Matsunaga A, Kutsuna T, Ishii A, Abe Y, Yoneki K, Harada M, Ishibashi M, Takeuchi Y, Yoshida A, Takahira N
  • Journal Title: The Scientific World Journal Volume: 2013 Issue: 1 Pages: 1-6
  • DOI: 10.1155/2013/780783
  • Peer Reviewed
• [Journal Article] Habitual physical activity measured by accelerometer and survival in maintenance hemodialysis patients (2012)
  • Author(s): Matsuzawa R, Matsunaga A, Wang G, Kutsuna T, Ishii A, Abe Y, Takagi Y, Yoshida A, Takahira N
  • Journal Title: Clinical Journal of the American Society of Nephrology Volume: 7 Pages: 2010-6
  • Peer Reviewed
• [Journal Article] Habitual physical activity measured by accelerometer and survival in maintenance hemodialysis patients (2012)
  • Author(s): Matsuzawa R, Matsunaga A, Wang G, Kutsuna T, Ishii A, Abe Y, Takagi Y, Yoshida A, Takahira N
  • Journal Title: Clinical Journal of The American Society of Nephrology Volume: 7 Pages: 2010-2010
  • Peer Reviewed
• [Journal Article] 維持血液透析患者の立位バランス機能の低下には末梢神経障害が強く関与している (2012)
  • Author(s): 阿部義史, 松沢良太, 室内直樹, 箕輪俊也, 石井玲, 重田暁, 松永篤彦
  • Journal Title: 臨床理学療法研究 Volume: 29 Pages: 47-47
  • Peer Reviewed
• [Journal Article] 透析患者への理学療法の関わり (2012)
  • Author(s): 松永篤彦
  • Journal Title: 理学療法学 Volume: 29 Pages: 1100-1100
• [Journal Article] 維持血液透析患者の立位バランス機能に影響を与える因子の検討 (2012)
  • Author(s): 阿部義史, 松永篤彦, 松沢良太, 室内直樹, 石井玲, 箕輪俊也, 米木慶, 重田 暁
  • Journal Title: 日本透析医学会雑誌 Volume: 45 Pages: 433-433
  • NAID: 10030814116
  • Peer Reviewed
• [Presentation] Association of daily physical activity with bone mass in hemodialysis patients (2013)
  • Author(s): Yoneki K, Matsunaga A, Kitagawa J, Matsuzawa R, Ishii A, Abe Y, Harada M, Takeuchi Y, Kamata K
  • Organizer: American Society of Nephrology(KIDNEY WEEK 2013)
  • Place of Presentation: Atlanta, Georgia, USA
• [Presentation] Effects of walking ability on risk of hospitalization for cardiocerebrovascular events in hemodialysis patients (2013)
  • Author(s): Abe Y, Matsunaga A, Matsuzawa R, Ishii A, Yoneki K, Harada M, Kutsuna T, Takeuchi Y, Yoshida A, Kamata K
  • Organizer: American Society of Nephrology (KIDNEY WEEK 2013)
  • Place of Presentation: Atlanta, Georgia, USA
• [Presentation] Association of physical activity with HDL-C level in hemodialysis patients (2013)
  • Author(s): Matsuzawa R, Matsunaga A, Ishii A, Abe Y, Yoneki K, Harada M, Takagi Y, Yoshida A, Kamata K, Takahira N
  • Organizer: American Society of Nephrology (KIDNEY WEEK 2013)
  • Place of Presentation: Atlanta, Georgia, USA
• [Presentation] Motor function and activities of daily living among ambulatory patients undergoing maintenance hemodialysis (2013)
  • Author(s): Harada M, Abe Y, Matsuzawa R, Ishii A, Yoneki K, Shigeta K, Abe H, Toda N, Kimura M, Shimizu S, Watanabe H, Matsunaga A
  • Organizer: The 6th Asia-Western Pacific Regional Congress of the World Confederation for Physical Therapy
  • Place of Presentation: Taichung, Taiwan
• [Presentation] Effects of physical activity on risk of hospitalization of cardio-cerebrovascular events in hemodialysis patients, European Renal Association-European-Dialysis-Transp lant-Association (ERA-EDTA) (2013)
  • Author(s): Matsuzawa R, Matsunaga A, Ishii A, Abe Y, Yoneki K, Harada M, Takagi Y, Yoshida A, Takahira N
  • Organizer: 50th Congress
  • Place of Presentation: Istanbul, Turkey
• [Presentation] EFFECTS OF PHYSICAL INACTIVITY ON RISK OF HOSPITALIZATION FOR CARDIO-CEREBROVASCULAR EVENTS IN HEMODIALYSIS PATIENTS (2013)
  • Author(s): Ryota Matsuzawa, Atsuhiko Matsunaga, Akira Ishii, Yoshifumi Abe, Kei Yoneki, Manae Harada, Yutaka Takagi, Atsushi Yoshida, Naonobu Takahira
  • Organizer: European Renal Association - European Dialysis Transplant Association (ERA-EDTA) 50th Congress,
  • Place of Presentation: Istanbul, Turkey
• [Presentation] MOTOR FUNCTION AND ACTIVITIES OF DAIRY LIVING AMONG AMBULATORY PATIENTS UNDERGOING MAINTENANCE HEMODIALYSIS (2013)
  • Author(s): Manae Harada, Yoshifumi Abe, Ryota Matsuzawa, Akira Ishii, Kei Yoneki, Kyo Shigeta, Hiroshi Abe, Naruaki Toda, Masahiko Kimura, Shinobu Shimizu, Hiroyuki Watanabe, Atsuhiko Matsunaga
  • Organizer: The 6th Asia-Western Pacific Regional congress of the world confederation for physical therapy
  • Place of Presentation: Taichung, Taiwan
• [Presentation] Effects of Walking Ability on Risk of Hospitalization for Cardio-cerebrovascular Events in Hemodialysis Patients (2013)
  • Author(s): Yoshifumi Abe, Atsuhiko Matsunaga, Ryota Matsuzawa, Akira Ishii, Kei Yoneki, Manae Harada, Toshiki Kutsuna，Yutaka Takagi, Atsushi Yoshida, Yasuo Takeuchi, Kouju Kamata
  • Organizer: American Society of Nephrology (ASN),KIDNEY WEEK2013
  • Place of Presentation: Atlanta, Georgia, the United States of America
• [Presentation] Association of daily physical activity with bone mass in hemodialysis patients (2013)
  • Author(s): Kei Yoneki, Atsuhiko Matsunaga, Jun Kitagawa, Ryota Matsuzawa, Akira Ishii, Yoshifumi Abe, Manae Harada, Yasuo Takeuchi, Atsushi Yoshida, Kouju Kamata
  • Organizer: American Society of Nephrology (ASN),KIDNEY WEEK2013
  • Place of Presentation: Atlanta, Georgia, the United States of America
• [Presentation] Association of physical activity with HDL-C level in hemodialysis patients (2013)
  • Author(s): Ryota Matsuzawa, Atsuhiko Matsunaga, Akira Ishii, Yoshifumi Abe, Kei Yoneki, Manae Harada, Yutaka Takagi, Atsushi Yoshida, Yasuo Takeuchi, Kouju Kamata, Naonobu Takahira
  • Organizer: American Society of Nephrology (ASN),KIDNEY WEEK2013
  • Place of Presentation: Atlanta, Georgia, the United States of America
• [Presentation] 身体活動量の低下は血液透析患者の脳・心血管疾患の発症を原因とする入院リスクを増加させる (2013)
  • Author(s): 松沢良太，松永篤彦，川口美保，石井 玲，阿部義史，箕輪俊也，米木 慶，原田愛永，宮川京子，高木 裕，吉田 煦，高平尚伸
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
• [Presentation] 維持血液透析患者の機能的移動能力の低下には末梢神経障害が強く関与している (2013)
  • Author(s): 阿部義史，松永篤彦，松沢良太，石井玲，箕輪俊也，米木慶，高木裕，吉田煦
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
• [Presentation] 維持血液透析患者の日常の身体活動量は骨密度と強く関連している (2013)
  • Author(s): 米木慶，松永篤彦，北川淳，松沢良太，石井 玲，阿部義史，箕輪俊也，吉田 煦
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
• [Presentation] 維持血液透析患者における移動動作時の困難さの出現には日常の身体活動量が関与する (2013)
  • Author(s): 箕輪俊也，松永篤彦，松沢良太，石井 玲，阿部義史，米木 慶，吉田 煦
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
• [Presentation] 副甲状腺機能が正常範囲にある維持血液透析患者の骨密度は身体活動量を管理することで低下を予防できる (2012)
  • Author(s): 阿部義史, 松永篤彦, 松沢良太, 室内直樹, 箕輪俊也, 石井玲, 清水絵里香, 志真奈緒子, 米木慶, 吉田照
  • Organizer: 第2回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-20
• [Presentation] Determinants of decreased walking speed among patients undergoing ambulatory hemodialysis (2012)
  • Author(s): Abe Y, Matsunaga A, Matsuzawa R, Ishii A, Minowa T, Yoneki K, Kutsuna T, Shigeta K, Kamata K
  • Organizer: American Society of Nephrology (KIDNEY WEEK 2012)
  • Place of Presentation: San Diego, USA
• [Presentation] Lower-extremity muscle strength and survival in hemodialysis patients : A prospective cohort study (2012)
  • Author(s): Matsuzawa R, Matsunaga A, Ishii A, Abe Y, Minowa T, Yoneki K, Takagi Y, Yoshida A, Kamata K, Takahira N
  • Organizer: American Society of Nephrology (KIDNEY WEEK 2012)
  • Place of Presentation: San Diego, USA
• [Presentation] 下肢筋力の低下は血液透析患者の死亡リスクを増大させる~7年間の前向きコホート研究 (2012)
  • Author(s): 松沢良太, 松永篤彦, 石井玲, 阿部義史, 箕輪俊也, 清水絵里香, 米木慶, 高木裕, 吉田照, 高平尚伸
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 血液透析患者が移動時に自覚する困難さの有無を規定する因子の検討 (2012)
  • Author(s): 箕輪俊也, 松永篤彦, 松沢良太, 志真奈緒子, 石井玲, 室内直樹, 阿部義史, 高木裕, 吉田照
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 血液透析患者の死体活動量低下には行動変容ステージが関与する (2012)
  • Author(s): 松沢良太, 松永篤彦, 石井玲, 室内直樹, 阿部義史, 箕輪俊也, 清水絵里香, 志真奈緒子, 米木慶, 吉田照, 高平尚伸
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
• [Presentation] 末梢神経障害の併存が維持血液透析患者のバランス機能に及ぼす影響 (2012)
  • Author(s): 阿部義史, 松永篤彦, 松沢良太, 室内直樹, 箕輪俊也, 石井玲, 志真奈緒子, 清水絵里香, 米木慶, 吉田照
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
• [Presentation] 維持血液透析患者が歩行時に困難感を生じないために維持すべき運動機能について (2012)
  • Author(s): 箕輪俊也, 忽那俊樹, 松沢良太, 志真奈緒子, 石井玲, 室内直樹, 阿部義史, 米木慶, 清水絵里香, 松永篤彦
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
• [Presentation] 維持血液透析患者の日常の身体活動量は骨密度と密接に関連している (2012)
  • Author(s): 米木慶, 松永篤彦, 北川淳, 松沢良太, 石井玲, 阿部義史, 箕輪俊也, 吉田照
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
• [Presentation] 維持血液透析患者の機能的移動能力の低下には末梢神経障害が強く関与している (2012)
  • Author(s): 阿部義史, 松永篤彦, 松沢良太, 石井玲, 箕輪俊也, 米木慶, 高木裕, 吉田照
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
• [Presentation] 維持血液透析患者における移動動作時の困難さの出現には日常の身体活動量が関与する (2012)
  • Author(s): 箕輪俊也, 松永篤彦, 松沢良太, 石井玲, 阿部義史, 米木慶, 吉田照
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
• [Presentation] Determinants of Decreased Walking Speed among Patients Undergoing Ambulatory Hemodialysis (2012)
  • Author(s): Yoshifumi Abe，Atsuhiko Matsunaga，Ryota Matsuzawa，Akira Ishii，Toshiya Minowa，Kei Yoneki，Toshiki Kutsuna，Kyo Shigeta，Kouju Kamata
  • Organizer: KIDNEY WEEK 2012( American Society of Nephrology)
  • Place of Presentation: San Diego, USA
• [Presentation] Lower-Etremity Muscle Strength and Survival in Hemodialysis Patients: A prospective cohort study (2012)
  • Author(s): Ryota Matsuzawa, Atsuhiko Matsunaga, Akira Ishii, Yoshifumi Abe, Toshiya Minowa, Kei Yoneki, Yutaka Takagi, Atsushi Yoshida, Kouju Kamata, Naonobu Takahira
  • Organizer: KIDNEY WEEK 2012( American Society of Nephrology)
  • Place of Presentation: San Diego, USA
• [Presentation] 下肢筋力の低下は血液透析患者の死亡リスクを増大させる～7年間の前向きコホート研究～ (2012)
  • Author(s): 松沢良太，松永篤彦，石井 玲，阿部義史，箕輪俊也，清水絵里香，米木 慶，高木 裕，吉田 煦，高平尚伸
  • Organizer: 第57回日本透析医学会
  • Place of Presentation: 札幌
• [Presentation] 血液透析患者の身体活動量の低下には行動変容ステージが関与する (2012)
  • Author(s): 松沢良太，松永篤彦，石井玲，室内直樹，阿部義史，箕輪俊也，清水絵里香，志真奈緒子，米木慶，吉田煦，高平尚伸
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
• [Presentation] 血液透析患者が移動動作時に自覚する困難さの有無を規定する因子の検討 (2012)
  • Author(s): 箕輪俊也，松永篤彦，松沢良太，志真奈緒子，石井玲，室内直樹，阿部義史，高木裕，吉田煦
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 維持血液透析患者が歩行動作に困難感を生じないために維持すべき運動機能について (2012)
  • Author(s): 箕輪俊也，忽那俊樹，松沢良太，志真奈緒子，石井玲，室内直樹，阿部義史，米木慶，清水絵里香，松永篤彦
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
• [Presentation] Relationship between bone mineral density and physical activity in daily life in patients undergoing maintenance hemodialysis (2011)
  • Author(s): Abe Y, Matsunaga A, Matsushima S, Kutsuna T, Matsuzawa R, Hemmi F, Murouchi N, Minowa T, Yamamoto S, Hayashi Y, Nemoto S, Motohashi S, Takagi Y, Yoshida A, Takahira N, Masuda T
  • Organizer: 16th World Physical Therapy International Congress
  • Place of Presentation: Amsterdam, Holland
  • Year and Date: 2011-06-20
• [Presentation] Effects of daily physical activity time on walking ability in ambulatory hemodialysis patients : a 3-year follow-up study (2011)
  • Author(s): Matsuzawa R, Matsunaga A, Kutsuna T, Yamamoto S, Hemmi F, Abe Y, Murouchi N, Takagi Y, Motohashi S, Yoshida A, Takahira N, Masuda T
  • Organizer: 16th World Physical Therapy International Congress
  • Place of Presentation: Amsterdam, Holland
  • Year and Date: 2011-06-20
• [Presentation] 維持血液透析患者の日常の身体活動量と骨密度の関連性について
  • Author(s): 阿部義史、松永篤彦・他
  • Organizer: 世界理学療法連盟学会 (WCPT 2011)
  • Place of Presentation: アムステルダムRAIコンベンションセンター（オランダ、アムステルダム）
• [Presentation] 維持血液透析患者の日常の身体活動量が歩行機能に及ぼす影響について
  • Author(s): 松沢良太、松永篤彦・他
  • Organizer: 世界理学療法連盟学会 (WCPT 2011)
  • Place of Presentation: アムステルダムRAIコンベンションセンター（オランダ、アムステルダム）
• [Presentation] 副甲状腺機能が正常範囲内にある維持血液透析患者の骨密度の低下は身体活動量を管理することで予防できる
  • Author(s): 阿部義史、松永篤彦・他
  • Organizer: 日本腎臓リハビリテーション学術集会
  • Place of Presentation: 仙台国際センター（仙台）