Study on the mechanism for immobilization induced muscular pain and on a method preventing generation of this painful state.
| Project/Area Number |
23500624
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya Gakuin University |
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Principal Investigator |
KOEDA Tomoko 名古屋学院大学, リハビリテーション学部, 教授 (20223050)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUMURA Kazue 中部大学, 生命健康科学部, 教授 (00109349)
NISHIGAMI Tomohiko 甲南女子大学, 看護リハビリテーション学部, 准教授 (60515691)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 関節不動化 / 筋性疼痛 / 疼痛行動評価 / カルシトニン遺伝子関連ペプチド / 神経成長因子 / 運動 / 不動化モデルラット / NGF / CGRP / 温水内自由運動 / ランダルセリットテスト / フォンフライテスト |
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| Research Abstract |
Both or unilateral ankle joints of intact rats were immobilized by plaster cast. We showed that the muscular mechanical hyperalgesia was induced after joint immobilization, without having tissue damage at light microscopic level. Nerve growth factor and calcitonin gene related peptide, which are involved in pain transmission, may be responsible for this painful condition of the muscle. Free movement for 15 min a day or free movement in the warm water for 20 min a day partially prevented from developing muscular hyperalgesia. Exercise before immobilization might also suppress this muscular pain.
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Report
(4 results)
Research Products
(40 results)
