| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Both or unilateral ankle joints of intact rats were immobilized by plaster cast. We showed that the muscular mechanical hyperalgesia was induced after joint immobilization, without having tissue damage at light microscopic level. Nerve growth factor and calcitonin gene related peptide, which are involved in pain transmission, may be responsible for this painful condition of the muscle. Free movement for 15 min a day or free movement in the warm water for 20 min a day partially prevented from developing muscular hyperalgesia. Exercise before immobilization might also suppress this muscular pain.
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