| Project/Area Number |
23500628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Aichi Medical University |
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Principal Investigator |
OHMICHI MIKA 愛知医科大学, 医学部, 助教 (30581079)
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| Co-Investigator(Kenkyū-buntansha) |
OHMICHI Yusuke 愛知医科大学, 医学部, 助教 (50506673)
OHISHI Hitoshi 愛知医科大学, 医学部, 准教授 (00252461)
大迫 洋治 高知大学, 医歯学系, 准教授 (40335922)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 不動化 / 慢性痛 / 自発運動 / 運動療法 / 神経科学 / 予防 |
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| Research Abstract |
The aim of the present study was the development of an effective therapy of chronic pain. In order to achieve it, we performed a series of experiments to confirm whether the preventive exercise is effective against the chronic pain. We let a group of rats exercise voluntary for 2 weeks using running wheel, while the other group did not do the exercise. Then we made chronic post-cast pain (CPCP) model and performed behavioral and immunohistochemical examination. We found that the chronic mechanical hyperalgesia in rats that exercised before CPCP was induced was more decrease compared with the rats that did not do the pre-exercise. Moreover, as the mechanical hyperalgesia of the tail farthest from the ipsilateral site is reduced, there occurs attenuation of the activation of microglia in the coccygeal cord. Those results suggested the possibility that the exercise performed before the onset of chronic pain may prevent the onset of chronic pain associated with hindlimb immobilization.
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