Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
| Project/Area Number |
23500629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kinki University |
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Principal Investigator |
ITOH Tatsuki 近畿大学, 医学部, 講師 (40330245)
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| Co-Investigator(Kenkyū-buntansha) |
SATOU Takao 近畿大学, 医学部附属病院, 教授 (70162443)
INOUE Takao 近畿大学, 医学部, 助教 (00441006)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | リハビリテーション / 神経再生 / 運動 / 脳外傷 / 高次脳機能改善 / 酸化ストレス / アポトーシス / 神経保護作用 / 神経再生促進効果 / 神経細胞死 / 高次機能改善 |
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| Research Abstract |
we investigate the effect of exercise on morphology and cerebral function following TBI in rats. Wistar rats received TBI by a pneumatic controlled injury device and were randomly divided into two groups: 1) non-exercise group and 2) exercise group. The exercise group ran on a treadmill. Immunohistochemical and behavioral studies were performed following TBI. The number of ssDNA-positive cells early after TBI was significantly reduced in the exercise group. Furthermore, most ssDNA-positive cells in the non-exercise group co-localized with neuronal cells. However, in the exercise group, few ssDNA-positive cells co-localized. In addition, there was a significant increase in neuronal cell number and improvement in cerebral dysfunction after TBI in the exercise group. These results indicate that exercise following TBI inhibits neuronal apoptotic cell death, which results in an improvement of cerebral dysfunction.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST22012
Author(s)
Tsubaki M , Satou T, Itoh T, Imano M, Yanae M, Kato C, Takagoshi R, Komai M, Nishida S
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Journal Title
Mol Cell Endocrinol
Volume: 361
Pages: 219-231
Related Report
Peer Reviewed
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[Journal Article] Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells2011
Author(s)
Tsubaki M, Satou T, Itoh T, Imano M, Komai M, Nishinobo M, Yamashita M, Yanae M, Yamazoe Y, Nishida S
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Journal Title
Leuk Res
Volume: 36
Pages: 1315-1322
Related Report
Peer Reviewed
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