The effect of rehabilitation on accumulation of Amyloid beta after onset of cerebral micro infarction.
| Project/Area Number |
23500631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
HIMI Naoyuki 川崎医科大学, 医学部, 助教 (70412161)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Osamu 川崎医科大学, 医学部, 教授 (00253287)
OKABE Naohiko 川崎医科大学, 医学部, 助教 (30614276)
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| Co-Investigator(Renkei-kenkyūsha) |
KOGA Tomoshige 川崎医療福祉大学, 医療技術学部, 教授 (50186649)
KUNIYASU Katsushi 川崎医療福祉大学, 医療技術学部, 教授 (10299258)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | リハビリテーション / 脳梗塞 / アミロイドβ / アルツハイマー |
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| Research Abstract |
The effects of exercise on spatial memory function recovery and accumulation of amyloid beta were tested using in a rat model of brain embolism. Intra-arterial microsphere (MS) injection induced multiple emboli in the rat brain and small multiple stroke were observed in the brain. Treadmill exercise was started after MS injection. The non-exercise (NE) and sham-operated groups were included as controls. Memory function was evaluated by the Morris water-maze (MWM) test and amyloid beta level was detected by histological method. Unfortunately, repeated MS injection was difficult and repeated onset of stroke was occured in no rat. After single onset of stroke, amyloid beta was not detected in every young and old stroke rats. However, memory function was recovered in exercise group. It was estimated that single onset of multiple stroke might provide less effect on accumulation of amyloid beta.
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Report
(4 results)
Research Products
(7 results)
