Elucidation of role of climbing fibers in memory trace of motor learning.

• Project/Area Number: 23500638
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TATSUKAWA TETSUYA 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (60435659)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 運動記憶 / 小脳核細胞 / シナプス可塑性 / 小脳 / 記憶の固定化 / 小脳核 / 国際情報交換 / 国際情報交流

Research Abstract

Long-term depression (LTD) of synaptic efficacy at parallel fiber-Purkinje cell synapses and long-term potentiation (LTP) of synaptic efficacy at mossy fiber-deep cerebellar nuclei neuron synapses provide the underlying mechanisms for memory trace of motor learning. We analyzed intracellular signaling for the induction of LTP at mossy fiber-deep cerebellar nuclei synapses by means of whole-cell patch clamp technique in acute cerebellar slices of nitric oxide synthase knockout mice. We found that nitric oxide-protein kinase G signaling regulated the LTP induction by intracellular calcium level through hyperpolarization-activated cation currents.

Research Products

• [Journal Article] Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic γ-aminobutyric acid receptors in mouse medial vestibular nuclear neurons (2013)
  • Author(s): Todaka H, Tatsukawa T, Hashikawa T, Yanagawa Y, Shibuki K and Nagao S
  • Journal Title: EJN Volume: 37 Pages: 339-350
  • Peer Reviewed
• [Journal Article] Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic γ-aminobutyric acid receptors in mouse medial vestibular nuclear neurons. (2013)
  • Author(s): Todaka H
  • Journal Title: Eur J Neurosci Volume: 37 Issue: 3 Pages: 339-350
  • DOI: 10.1111/ejn.12051
  • Peer Reviewed
• [Journal Article] Clinical Neuroscience (2011)
  • Author(s): 立川哲也, 中外医学社
  • Journal Title: Neuroplasticity-脳は実は柔らかい Volume: Vol.29 (7) Pages: 740-744
• [Presentation] オーファン受容体GPRC5Bノックアウトマウスは小脳プルキンエ細胞の軸索変性によりその運動協調・学習機能が障害される (2013)
  • Author(s): 木下雅美, 佐野孝光, 大嶋恵理子, 清水知佳, 濱裕, 遠山稿二郎, 立川哲也, Dinh Tung Le, 鈴木寿紀, 山田一之, 宮脇敦, 永雄総一, 平林義雄
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] GPRC5B KO mice are induced axon degeneration in cerebellar Purkinje neurons, resulting in impaired motor coordination and learning (2013)
  • Author(s): Kinoshita Masami, Sano Takamitsu, Ooshima Eriko, Shimizu Chika, Hama Hiroshi, Tohyama Koujiro, Tatsukawa Tetsuya, Le Dinh Tung, Suzuki Toshinori, Yamada Kazuyuki, Miyawaki Atsushi, Nagao Souichi, Hirabayashi Yoshio
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] 苔状線維-小脳核細胞シナプスにおける一酸化窒素によるHCNを介したLTPの制御 (2012)
  • Author(s): 立川哲也, 永雄総一
  • Organizer: 第89回日本生理学会
  • Place of Presentation: 長野
  • Year and Date: 2012-03-29