| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
The prevalence of bronchial asthma is known to be higher in athlete population than general population. The influence for bronchoconstriction and airway inflammation is not fully elucidated and the investigation of these mechanisms will be contributed to precise diagnosis and proper treatment.
In this study, we established the murine model of forced exercise using Balb/c mice and treadmill for mouse. Airway hyperresponsiveness to methacholine, airway smooth muscle hyperplasia and the deposition of collagen on submucosal area were recognized and correlated with exercise duration. It is thought to be airway remodeling associated with strenuous exercise. The investigation of the mechanism in detail should be elucidated near future.
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