The establishment and analysis of exercise induced asthma model in mice

• Project/Area Number: 23500775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Niigata University
• Principal Investigator: SUZUKI EIICHI 新潟大学, 医歯学総合病院, 教授 (30187710)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Takashi 新潟大学, 医歯学総合病院, 准教授 (90361906) ; KOYA Toshiyuki 新潟大学, 医歯学総合病院, 講師 (90444158)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 運動誘発性喘息 / マウス / リモデリング / 気道過敏性亢進 / 気道傷害 / 吸入ステロイド / 低温負荷 / 血管増殖因子

Outline of Final Research Achievements

The prevalence of bronchial asthma is known to be higher in athlete population than general population. The influence for bronchoconstriction and airway inflammation is not fully elucidated and the investigation of these mechanisms will be contributed to precise diagnosis and proper treatment.
In this study, we established the murine model of forced exercise using Balb/c mice and treadmill for mouse. Airway hyperresponsiveness to methacholine, airway smooth muscle hyperplasia and the deposition of collagen on submucosal area were recognized and correlated with exercise duration. It is thought to be airway remodeling associated with strenuous exercise. The investigation of the mechanism in detail should be elucidated near future.

Research Products

• [Presentation] マウスを用いた運動誘発性気管支収縮モデルの解析 (2015)
  • Author(s): 月岡啓輔, 小屋俊之, 青木亜美, 竹内寛之, 外山美央, 黒川 允, 木村夕香, 林 正周, 坂上拓郎, 長谷川隆志, 成田一衛
  • Organizer: 日本アレルギー学会学術集会
  • Place of Presentation: 高輪プリンスホテル、東京
  • Year and Date: 2015-05-26 – 2015-05-28
• [Presentation] Analysis of the Mechanism of Exercise Induced Bronchoconstriction in Murine Model (2015)
  • Author(s): Keisuke Tsukioka, Toshiyuki Koya, Hiroyuki Takeuchi, Ami Aoki, Mio Toyama, Makoto Kurokawa, Yuka Kimura, Masachika Hayashi, Takuro Sakagami, Takashi Hasegawa, Eiichi Suzuki, Ichiei Narita
  • Organizer: American Thoracic Society
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2015-05-16 – 2015-05-20
• [Presentation] 当科において診断したアスリート喘息患者の解析 (2012)
  • Author(s): 小屋俊之ら
  • Organizer: 第23回臨床スポーツ医学会学術集会
  • Place of Presentation: 横浜