| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Using senescent mice (24-month-old), I investigated the adaptive changes in autophagy-linked molecules in skeletal muscle. In aged mice, we observed the marked increase in the amount of p62/SQSTM1 and Beclin-1 protein in cytosol fraction but not membrane and nuclear fraction in quadriceps muscle. Immunofluorescence indicated the marked accumulation of p62/SQSTM1 but not LC3 in the cytosol of sarcopenic muscle fibers of mice. Although voluntary exercise attenuated the sarcopenic symptom, there is no significant change in autophagy-linked molecule.
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