Does protein degradation by autophagy induce sarcopenia?
| Project/Area Number |
23500778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 加齢 / 骨格筋 / 運動 / サルコペニア / オートファジー / 筋萎縮 |
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| Research Abstract |
Using senescent mice (24-month-old), I investigated the adaptive changes in autophagy-linked molecules in skeletal muscle. In aged mice, we observed the marked increase in the amount of p62/SQSTM1 and Beclin-1 protein in cytosol fraction but not membrane and nuclear fraction in quadriceps muscle. Immunofluorescence indicated the marked accumulation of p62/SQSTM1 but not LC3 in the cytosol of sarcopenic muscle fibers of mice. Although voluntary exercise attenuated the sarcopenic symptom, there is no significant change in autophagy-linked molecule.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise2013
Author(s)
Aoi W, Naito Y, Takagi T, Tanimura T, Takanami Y, Kawai Y, Sakuma K, Hang LP, Mizushima K, Hirai Y, Koyama R, Wada S, Higashi A, Kokura S, Ichikawa H, Yoshikawa T
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Journal Title
Gut
Volume: 62
Pages: 882-889
Related Report
Peer Reviewed
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