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Effect of exercise training on endogenous carbon monoxide exhalation in humans.

Research Project

Project/Area Number 23500779
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionToyohashi University of Technology

Principal Investigator

YASUDA Yoshifumi  豊橋技術科学大学, 工学部, 教授 (70126952)

Co-Investigator(Kenkyū-buntansha) SAITO Yoshihiro  豊橋技術科学大学, 大学院・工学研究科, 准教授 (00303701)
SAKUMA Kunihiro  豊橋技術科学大学, 工学部, 准教授 (60291176)
NIWAYAMA Masatsugu  静岡大学, 工学部, 准教授 (40334958)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsガス状伝達物質 / 一酸化炭素 / 硫化水素 / ヘムオキシゲナーゼ / パルスオキシメータ / カーボライザー / 呼気ガス / 一酸化窒素 / カルボキシヘモグロビン / heme oxygenase / 運動 / トレーニング
Research Abstract

In the present study we aimed to measure exhaled carbon monoxide (CO) during and after exercise in smokers and non-smokers. We could observe that exhaled carbon oxide increased relatve to exercise intensity and decreased rapidly after exercise. The amounts of CO exhalation in smokers were significantly larger than those of non-smokers. We also attempted to develop a prototype model to estimate carboxyhemoglobin concentrations (COHb) transcutaneously in the blood using multi-wavelength optical sources. The COHb could be continuously measured by a prototype model, however problems relevant to the stability and resolution still remained. Furthermore, we also measured the expression of heme oxygenase-1 and -2 which are the enzymes producing CO in mice, and found that the expression of these enzymes in the skeletal muscles increased with acute exercise and strength training.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (46 results)

All 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 13 results) Presentation (21 results) (of which Invited: 1 results) Book (7 results)

  • [Journal Article] ランプ負荷運動時における呼気硫化水素排出量の動態2014

    • Author(s)
      安田好文
    • Journal Title

      豊橋技術科学大学総合教育院紀要

      Volume: 36 Pages: 77-87

    • NAID

      120005428978

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Implantable thin NIRS probe design and sensitivity distribution analysis.2014

    • Author(s)
      M. Niwayama, T. Yamakawa
    • Journal Title

      Electronics Letters

      Volume: 50 Issue: 5 Pages: 346-348

    • DOI

      10.1049/el.2013.3921

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development od an implantable flexible probe for simultaneous near-infrared spectroscopy and electrocorticography.2014

    • Author(s)
      T. Yamakawa, T. Inoue, Y. He, M. Fujii, M. Suzuki, M. Niwayama
    • Journal Title

      IEEE Trans. Biomed. Eng.

      Volume: 61 Issue: 2 Pages: 388-395

    • DOI

      10.1109/tbme.2013.2279888

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Needle-type Extraction Device Designed for Rapid and Sensitive Analysis in Gas Chromatography2014

    • Author(s)
      I. Ueta, Y. Saito
    • Journal Title

      Analytical Sciences

      Volume: 30 Issue: 1 Pages: 105-110

    • DOI

      10.2116/analsci.30.105

    • NAID

      130004442230

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Double-bed-type extraction needle packed with activated-carbon-based sorbents for very volatile organic compound2014

    • Author(s)
      I. Ueta, E.L. Samsudin, A. Mizuguchi, H. Takeuchi, T. Shinki, S. Kawakubo, Y. Saito
    • Journal Title

      J. Pharm. Biomed. Anal

      Volume: 88 Pages: 423-428

    • Related Report
      2013 Final Research Report
  • [Journal Article] Double-bed-type extraction needle packed with activated-carbon-based sorbents for very Volatile organic compaound.2014

    • Author(s)
      I. Ueta, E. L. Samsudin, A. Mizuguchi, H. Takeuchi, T. Shinki, S. Kawakubo, Y. Saito
    • Journal Title

      J. Pharm. Biomed. Anal.

      Volume: 88 Pages: 423-428

    • DOI

      10.1016/j.jpba.2013.09.028

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiological significance of measuring exhaled gasotransmitters during exercise2013

    • Author(s)
      Y. Yasuda
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 2 Issue: 3 Pages: 311-318

    • DOI

      10.7600/jpfsm.2.311

    • NAID

      10031179353

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum response factor (SRF)-dependent signaling in regenerating, hypertrophied, and pathological skeletal muscle2013

    • Author(s)
      K. Sakuma, A. Yamaguchi
    • Journal Title

      Fron. Pathol. Genet

      Volume: 1 Pages: 1-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] ヘッドスペース法を用いた血中一酸化炭素濃度測定の有効性2013

    • Author(s)
      安田好文, 竹内隼人, 齊戸美弘
    • Journal Title

      豊橋技術科学大学総合教育院紀要

      Volume: 35 Pages: 47-55

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Serum response factor (SRF)-dependent signaling in regenerating, hypertrophied, and pathological skeletal muscle.2013

    • Author(s)
      K. Sakuma, A. Yamaguchi
    • Journal Title

      Font. Pathol. Genet.

      Volume: 1 Pages: 1-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Error factors in oxygenation measurement using continuous and spatially resolved near-infrared spectro2012

    • Author(s)
      M. Niwayama, H. Suzuki, T. Yamashita, Y. Yasuda
    • Journal Title

      J. Japanese College Angiology

      Volume: 52 Pages: 211-215

    • Related Report
      2013 Final Research Report
  • [Journal Article] Column switching analysis with packed-capillary columns in gas Chromatography.2012

    • Author(s)
      Ueta I, Takahashi K, Saito Y
    • Journal Title

      Analytical Sciences

      Volume: 28 Pages: 953-957

    • NAID

      10031123427

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel sample preparation tehnique with needle-type micro-extraction device for volatile organic compounds in indoor air samples.2012

    • Author(s)
      Ueta I, Mizuguchi A, Fujimura K, Kawakubo K, Saito Y
    • Journal Title

      Analytical Chimica Acta

      Volume: 746 Pages: 77-83

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent research developments in regeneration of skeletal muscle.2012

    • Author(s)
      Sakuma K, Yamaguchi A
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 1 Pages: 401-411

    • NAID

      10031158971

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimal filter bandwidth for pusle oximeterl2012

    • Author(s)
      Staban N, Niwayama M
    • Journal Title

      Rev Sci Instru

      Volume: 83 Pages: 1-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Error factors in oxygenation measurement using continuous wave and spatially resolved near-infrared spectroscopy.2012

    • Author(s)
      Niwayama M, Suzuki H, Yamashita T, Yasuda Y.
    • Journal Title

      The Journal of Japanese College of Angiology

      Volume: 52 Pages: 211-215

    • NAID

      130004903391

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of ramp bicycle exercise on exhaled carbon monoxide in humans2011

    • Author(s)
      Y. Yasuda, T. Ito, M. Miyamura, and M. Niwayama
    • Journal Title

      J. Physiol. Sci

      Volume: 201143 Issue: 4 Pages: 1-8

    • DOI

      10.1007/s12576-011-0145-z

    • NAID

      10029323482

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ガスクロマトグラフィーのための針型試料前処理デバイス2011

    • Author(s)
      植田郁生、齊戸美弘
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 60 Pages: 833-844

    • NAID

      10030038180

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ペダリング技術が自転車運動の伝達効率および酸素摂取量に及ぼす影響2014

    • Author(s)
      木梨公介, 安田好文, 河村正造
    • Organizer
      日本体力医学会東海地方会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] ペダリング技術が自転車運動の力の伝達効率, 筋電図, および機械的効率に及ぼす影響2013

    • Author(s)
      木梨公介, 安田好文, 河村正造, 田畑昭英
    • Organizer
      スポーツアンドヒューマンダイナミックス2013
    • Related Report
      2013 Final Research Report
  • [Presentation] Quantitative and convenient measurement of hemodynamics using spatially-resolved infrared spectroscopy2013

    • Author(s)
      M. Niwayama
    • Organizer
      International Symposium of Interdiciplinary Domain Research 2013
    • Related Report
      2013 Final Research Report
  • [Presentation] NIRS による筋組織を対象とした関心領域の酸素濃度測定2013

    • Author(s)
      塩見将平, 庭山正嗣
    • Organizer
      平成25年度日本生体医工学東海支部大会
    • Related Report
      2013 Final Research Report
  • [Presentation] サルコぺニア(加齢性菌減弱症)の分子メカニズム2013

    • Author(s)
      佐久間邦弘, 山口明彦
    • Organizer
      第68回日本体力医学会大会
    • Related Report
      2013 Final Research Report
  • [Presentation] 室内空気中の揮発性有機化合物濃縮用の粒子2層充填型抽出針の開発2013

    • Author(s)
      水口礼子, 植田郁生, 川久保進, 齊戸美弘
    • Organizer
      日本分析化学会第73回分析化学討論会
    • Related Report
      2013 Final Research Report
  • [Presentation] ペダリング技術が自転車運動の力の伝達効率、筋電図、および機械的効率に及ぼす影響2013

    • Author(s)
      木梨公介、安田好文、河村庄造、田畑昭秀
    • Organizer
      スポーツ・アンド・ヒューマンダイナミックス2013
    • Place of Presentation
      工学院大学(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quantitative and convinient measurement of hemodynamics using spatially-resolved near infrared spectroscopy.2013

    • Author(s)
      M. Niwayama
    • Organizer
      International Symposium of Interdisciplinary Domain Research 2013
    • Place of Presentation
      Shizuoka Convention and Arts Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] サルコペニア(加齢性筋減弱症)の分子メカニズム2013

    • Author(s)
      佐久間邦弘、山口明彦
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      日本教育会館(東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 室内空気中の揮発性有機化合物濃縮用の粒子2層充填型抽出針の開発2013

    • Author(s)
      水口礼子、植田郁生、川久保進、齊戸美弘
    • Organizer
      日本分析化学会第73回分析化学討論会
    • Place of Presentation
      北海道大学函館キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] ペダリング技術が力の伝達効率に及ぼす影響2013

    • Author(s)
      木梨公介、安田好文、河村庄造、田畑昭秀
    • Organizer
      日本体力医学会東海地方会
    • Place of Presentation
      愛知学院大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Miniaturized sample preparation needle for human breath analysis in capillary gas chromatography2012

    • Author(s)
      Y. Saito, K Ueta, S. Fujimura A. Ellwood
    • Organizer
      International Breath Research
    • Place of Presentation
      USA
    • Related Report
      2013 Final Research Report
  • [Presentation] カオス解析を用いた高齢者の歩容に関する研究2012

    • Author(s)
      野中修一, 安田好文, 河村庄造
    • Organizer
      医学・工学における逆問題とその周辺研究会
    • Related Report
      2013 Final Research Report
  • [Presentation] ペダルの引き上げ動作が自転車運動の力の伝達効率に及ぼす影響2012

    • Author(s)
      木梨公介、安田好文、河村庄造、田畑昭秀
    • Organizer
      スポーツ・アンド・ヒューマン・ダイナミックス2012
    • Place of Presentation
      愛知大学豊橋キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] 歩行補助具が高齢者の歩容に及ぼす影響2012

    • Author(s)
      野中修一、安田好文、河村庄造
    • Organizer
      スポーツ・アンド・ヒューマン・ダイナミックス2012
    • Place of Presentation
      愛知大学豊橋キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] カオス解析を用いた高齢者の歩容に関する研究2012

    • Author(s)
      野中修一、安田好文、河村庄造
    • Organizer
      医学・工学における逆問題とその周辺(4)研究会
    • Place of Presentation
      統計数理研究所
    • Related Report
      2012 Research-status Report
  • [Presentation] Miniaturized sample preparation needle for human breath analysis in capillary gas chromatography.2012

    • Author(s)
      Saito Y, Ueta K, Fujimura S, Ellwood, et al.
    • Organizer
      2012 International Breath Analysis
    • Place of Presentation
      Sonoma, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of ramp bicycle exercise on carbon monoxide exhalation in smokers and non-smokers2011

    • Author(s)
      Y. Yasuda, T. Ito, M. Miyamura, M. Niwayama
    • Organizer
      International Conference on Breath Research
    • Place of Presentation
      Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of ramp bicycle exercise on carbon monoxide exhalation in smokers and non-smokers.2011

    • Author(s)
      Yasuda Y, Ito T, Miyamura M, Niwayama M.
    • Organizer
      International Conference on Breath Research
    • Place of Presentation
      Parma, Italy
    • Related Report
      2011 Research-status Report
  • [Presentation] ペダリング技術が自転車運動の伝達効率および酸素摂取量に及ぼす影響

    • Author(s)
      木梨公介、安田好文、河村庄造
    • Organizer
      日本体力医学会東海地方会学術集会
    • Place of Presentation
      愛知健康の森健康科学総合センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] NIRSによる筋組織を対象とした関心領域の酸素濃度測定

    • Author(s)
      塩見将平、庭山雅嗣
    • Organizer
      平成25年度日本生体医工学東海支部大会
    • Place of Presentation
      (株)スズケン本社(名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Book] An overview of the therapeutic strategies for preventing sarcopenia. (In) K. Sakuma (Ed)2013

    • Author(s)
      K. Sakuma, A. Yamaguchi
    • Publisher
      Nova Science Publishers
    • Related Report
      2013 Final Research Report
  • [Book] Photon migration in tissue, (In) J. Thmas, K. Masuda (Eds), Application of near infrared spectroscopy in biomedicine2013

    • Author(s)
      M. Niwayama, Y. Yamashita
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Book] Basic biology and Current understanding of skeletal muscle.2013

    • Author(s)
      K. Sakuma (Editor and Co-author)
    • Total Pages
      318
    • Publisher
      Nova Science Publishers
    • Related Report
      2013 Annual Research Report
  • [Book] Springer2013

    • Author(s)
      Niwayama M, et al.
    • Total Pages
      160
    • Publisher
      Application of Near Infrared Spectroscopy in Biomedicine
    • Related Report
      2012 Research-status Report
  • [Book] 呼気微量ガス2012

    • Author(s)
      安田好文
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2013 Final Research Report
  • [Book] 身体運動と呼吸・循環機能2012

    • Author(s)
      宮村実晴
    • Total Pages
      342
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2012 Research-status Report
  • [Book] 身体運動と呼吸・循環機能2012

    • Author(s)
      安田好文(監修:宮村実晴)
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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