| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Plasma ghrelin level was significantly reduced by acute moderate exercise. In addition, plasma growth hormone (GH) and catecholamine levels were significantly increased during the exercise. Plasma ghrelin level was negatively correlated with plasma catecholamine level. Single administration of ghrelin to type 2 diabetic patients just before the test meal did not change the plasma glucose and insulin responses compared to control. Ghrelin 1.0 mmg/kg/day administration for 2-weeks increased plasma GH levels and did not change the body weight, plasma glucose and insulin levels in type 2 diabetic patients. Subjective symptoms of diabetic peripheral neuropathy and motor conduction velocity were significantly improved after 2-weeks administration of ghrelin. These results suggest that exogenous ghrelin administration, especially during exercise, increases plasma GH level additively without worsening glucose metabolism and ghrelin may have therapeutic potentials to diabetic polyneuropathy.
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