Resistance training with blood flow restriction: from basic physiological study to creative clinical application
Project/Area Number |
23500784
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Sports science
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Research Institution | Hokusho University |
Principal Investigator |
OKITA KOICHI 北翔大学, 北翔大学, 教授 (80382539)
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Co-Investigator(Kenkyū-buntansha) |
KINUGAWA Shintaro 北海道大学医学研究科, 循環病態内科学, 講師 (60399871)
YOKOTA Takashi 北海道大学医学研究科, 循環病態内科学, 助教 (90374321)
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Co-Investigator(Renkei-kenkyūsha) |
HORIUCHI Masahiro 山梨県環境科学研究所, 生理学研究室, 室長 (50310115)
MORITA Noriteru 北海道教育大学, 教育学部, 准教授 (10382540)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 筋力トレーニング / エネルギー代謝 / 血流制限 / ミオカイン / BDNF / レジスタンス・トレーニング / 筋肥大 / 脳性神経栄養因子 |
Research Abstract |
We demonstrated that enhanced metabolic stress in exercising muscle is a key mechanism for favorable effects by resistance training and the elevated metabolic stress appears to be a crucial factor in obtaining successful results from resistance training (J Appl Physiol 2012). Based on these findings, we proposed the guidelines of resistance exercise with blood flow restriction for healthy subjects and diseased subjects such as diabetes and heart failure by considering individual characteristics, training status, disease status, age, and gender difference (Med Sci Sports Exerc 2012, Eur J Appl Physiol 2012, Jpn Coll Angiol 2012, Circ J 2013). Moreover, we applied this procedure to different types of athletes, sprinters and endurance runners, and also young athletes (Int J Vasc Med 2012, J Nov Physiother 2013).
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Report
(4 results)
Research Products
(80 results)
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[Journal Article] Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice.2014
Author(s)
Suga T, Kinugawa S, Takada S, Kadoguchi T, Fukushima A, Homma T, Masaki Y, Furihata T, Takahashi M, Sobirin MA, Ono T, Hirabayashi K, Yokota T, Tanaka S, Okita K, Tsutsui H.
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Journal Title
Endocrinology
Volume: 155
Issue: 1
Pages: 68-80
DOI
Related Report
Peer Reviewed
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[Journal Article] Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure.2013
Author(s)
Fukushima A1, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Abe T, Suga T, Takada S, Kadoguchi T, Katsuyama R, Oba K, Okita K, Tsutsui H.
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Journal Title
International Journal of Cardiology
Volume: 168
Issue: 5
Pages: e142-e144
DOI
Related Report
Peer Reviewed
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[Journal Article] Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome2013
Author(s)
Yokota T, Kinugawa S, Yamato M, Hirabayashi K, Suga T, Takada S, Harada K, Morita N, Oyama-Manabe N, Kikuchi Y, Okita K, Tsutsui H.
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Journal Title
Diabetes Care
Volume: 36
Issue: 5
Pages: 1341-1346
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased plasma soluble (pro) renin receptor levels are correlated with renal dysfunction in patients with heart failure.2013
Author(s)
Fukushima A1, Kinugawa S, Homma T, Masaki Y, Furihata T, Abe T, Suga T, Takada S, Kadoguchi T, Okita K, Matsushima S, Tsutsui H
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Journal Title
International Journal of Cardiology
Volume: 168
Issue: 4
Pages: 4313-4314
DOI
Related Report
Peer Reviewed
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[Journal Article] Angiotensin II Receptor Blocker Improves the Lowered Exercise Capacity and Impaired Mitochondrial Function of the Skeletal Muscle in Type 2 Diabetic Mice.2013
Author(s)
Takada S, Kinugawa S, Hirabayashi K, Suga T, Yokota T, Takahashi M, Fukushima A, Homma T, Ono T, Sobirin MA, Masaki Y, Mizushima W, Kadoguchi T, Okita K, Tsutsui H.
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Journal Title
Journal of Applied Physiology
Volume: 114
Issue: 7
Pages: 844-857
DOI
Related Report
Peer Reviewed
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[Journal Article] Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions2012
Author(s)
Takada S, Okita K, Suga T, Omokawa M, Kadoguchi T, Sato T, Takahashi M, Yokota T, Hirabayashi K, Morita N, Horiuchi M, Kinugawa S, Tsutsui H
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Journal Title
J Appl Physiol
Volume: 113
Pages: 199-205
Related Report
Peer Reviewed
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[Journal Article] Blood Flow Restriction Exercise in Sprinters and Endurance Runners2012
Author(s)
Takada S, Okita K, Suga T, Omokawa M, Morita N, Horiuchi M, Kadoguchi T, Takahashi M, Hirabayashi K, Yokota T, Kinugawa S, Tsutsui H
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Journal Title
Med Sci Sports Exerc
Volume: 44
Pages: 413-9
Related Report
Peer Reviewed
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[Journal Article] Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction2012
Author(s)
Suga T, Okita K, Takada S, Omokawa M, Kadoguchi T, Yokota T, Hirabayashi K, Takahashi M, Morita N, Horiuchi M, Kinugawa S, Tsutsui H
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Journal Title
Eur J Appl Physiol
Volume: 108
Pages: 1563-7
NAID
Related Report
Peer Reviewed
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[Presentation] Decreased Brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure2014
Author(s)
Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Takada S, Kadoguchi T, Katsuyama R, Okita K, Tsutsui H
Organizer
The 78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Brain-derived neurotrophic factor regulates exercise capacity and mitochondrial function in the skeletal muscle in mice2014
Author(s)
Takada S, Kinugawa S, Matsushima S, Yokota T, Fukushima A, Homma T, Kadoguchi T, Masaki Y, Furihata T, Katsuyama R, Okita K, Tsutsui H
Organizer
The 78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Serum myostatin levels are independent determinant of skeletal muscle wasting in patients with heart failure2014
Author(s)
Furihata T, Kinugawa S, Fukushima A, Homma T, Masaki Y, Katsuyama R, Takada S, Kadoguchi T, Matsushima S, Yokota T, Okita K, Tsutsui H
Organizer
The 78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Decreased Serum Brain-Derived Neurotrophic Factor Levels are Associated with Exercise Intolerance in Patients with Heart Failure2013
Author(s)
Takada S, Kinugawa S, Fukushima A, Homma T, Furihata T, Katsuyama R, Yokota T, Matsushima S, Abe T, Suga T, Kadoguchi T, Okita K, Tsutsui H
Organizer
86th Scientific Session of American Heart Association
Place of Presentation
Dallas, USA
Related Report
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[Presentation] Effect of Blood Flow Restriction Timing in Enhancing Intramuscular Metabolic Stress During Resistance Exercise2013
Author(s)
Okita K, Takada S, Suga T, Kadoguchi T, Sato T, Morita N, Taniura T, Horiuchi M, Kinugawa S, Tsuitsui H
Organizer
18th annual congress of European college of sports science
Place of Presentation
Bacelona, Spain
Related Report
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[Presentation] Dipeptidyl Peptidase-4 Inhibitor Improved Exercise Capacity in Association with Switching to Oxidative Skeletal Muscle Fiber Type in Mice with Post-infarct Heart Failure2013
Author(s)
Masaki Y, Kinugawa S, Yokota T, Matsushima S, Fukushima A, Takada S, Furihata T, Kadoguchi T, Katsuyama R, Okita K, Tsutsui H
Organizer
86th Scientific Session of American Heart Association
Place of Presentation
Dallas, USA
Related Report
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[Presentation] Serum Myostatin Levels are Independent Determinant of Skeletal Muscle Wasting in Patients with Heart Failure2013
Author(s)
Furihata T, Kinugawa S, Fukushima A, Homma T, Masaki Y, Abe T, Takada S, Kadoguchi T, Okita K, Matsushima S, Yokota T, Tsutsui H
Organizer
86th Scientific Session of American Heart Association
Place of Presentation
Dallas, USA
Related Report
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[Presentation] Increased Plasma Soluble (Pro)renin Receptor Levels are Correlated with Renal Dysfunction in Patients with Heart Failure2013
Author(s)
Katsuyama R, Kinugawa S, Fukushima A, Homma T, Masaki Y, Furihata T, Abe T, Takada S, Kadoguchi T, Okita K, Matsushima S, Tsutsui H
Organizer
86th Scientific Session of American Heart Association
Place of Presentation
Dallas, USA
Related Report
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[Presentation] BDNF-TrkB Pathway Plays an Important Role in the Effects of Exercise Training on Exercise Capacity and Skeletal Muscle Function in Mice. Circulation. 126: A145102012
Author(s)
Takada S, Kinugawa S, Suga T, Fukushima A, Homma T, Masaki Y, Kadoguchi T, Furihata T, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Sessions
Place of Presentation
Los Angeles, CA, USA
Related Report
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[Presentation] Effect of Exercise with Blood Flow Restriction Depends on Total Work Regardless of Mechanical Intensity2012
Author(s)
Takada S, Okita K, Omokawa M, Suga T, Morita N, Horiuchi M, Kadoguchi T, Sato T, Takahashi M, Fukushima A, Honma T, Masaki Y, Kinugawa S, Tsutsui H
Organizer
ACSM 59th Annual Meeting and and World Congress on Exercise is Medicine
Place of Presentation
San Francisco, CA, USA
Related Report
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[Presentation] Supplementation of Blood Flow Restriction During Resistance Training: Examination of Its Timings2011
Author(s)
Sato T, Okita K, Takada S, Suga T, Morita N, Horiuchi M, Kadoguchi T, Taniura T, Takahashi M, Fushima A, Kinugawa S, Tsutsui H.
Organizer
The 5th Asia-Pacific Conference on Exercise and Sports Science
Place of Presentation
Shanghai University of Sports, Shanghai, China
Related Report
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[Presentation] Muscular Metabolic Stress During Resistance Exercise with Blood Flow Restriction in Men and Women2011
Author(s)
Taniura T, Okita K, Takada S, Suga T, Morita N, Horiuchi M, Kadoguchi T, Sato T, Takahashi M, Fushima A, Kinugawa S, Tsutsui H.
Organizer
The 5th Asia-Pacific Conference on Exercise and Sports Science
Place of Presentation
Shanghai University of Sports, Shanghai, China
Related Report
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[Presentation] Low-intensity Resistance Exercise with Blood Flow Restriction can Induce Significant Metabolic Stress in Patients with Heart Failure2011
Author(s)
Takahashi M, Kinugawa S, Fukushima A, Takada S, Suga T, Yokota T, Hirabayashi K, Satou T, Kadoguchi K, Okita K, Tsutsui H.
Organizer
The 75th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Yokohama
Related Report
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[Presentation] Nitric Oxide is Involved the Beneficial Effects of Exercise Training via Activating Skeletal Muscle Mitochondrial Biogenesis in Mice2011
Author(s)
Suga T, Kinugawa S, Ono T, Yokota T, Takada S, Mochamad A, Takahashi M, Fukushima A, Honma T, Kadoguchi T, Masaki Y, Hirabayashi K, Okita K, Tsutsui H.
Organizer
American Heart Association
Place of Presentation
Orland USA
Related Report
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