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Genetic strain differences for strength training trainablitiy in rats and its application for understanding of muscle hypertrophy

Research Project

Project/Area Number 23500788
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionNippon Sport Science University

Principal Investigator

NAKAZATO Koichi  日本体育大学, 体育学部, 教授 (00307993)

Co-Investigator(Kenkyū-buntansha) OCHI Eisuke  明治学院大学, 教養部, 准教授 (90468778)
HIROSE Tatsuro  横浜桐蔭大学, スポーツ健康科学部, 講師 (80468800)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords筋肥大 / 動物モデル / ラット / 個体差 / タンパク質合成 / タンパク質分解 / 種特異性 / 筋タンパク質合成 / トレーニング / 系統種
Research Abstract

It has been well recognized that trainability for strength training varies depending on individual difference. In this study, we originally developed strength training model for rats and found that genetic strain difference exist for strength training. Sprague Dawley rat shows significant muscle hypertrophy with strength training but Wistar rats did not. We also found that mixture of different muscle contraction modes (isometric contractions and isometric contractions) and low frequency electrical stimulation are effective for muscle hypertrophy in Wistar strain with low response for strength training. Since electrical stimulation has been used in rehabilitation, low frequency electrical stimulation will be useful not only for low responder but for injured athletes.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] Effect of intermittent low-frequency electrical stimulation on the rat gastrocnemius muscle.2013

    • Author(s)
      Tsutaki A1, Ogasawara R, Kobayashi K, Lee K, Kouzaki K, Nakazato K.
    • Journal Title

      Biomed Res Int.

      Volume: 2013 Pages: 480620-480620

    • DOI

      10.1155/2013/480620

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic strain-dependent protein metabolism and muscle hypertrophy under chronic isometric training in rat gastrocnemius muscle.2013

    • Author(s)
      Kobayashi K, Ogasawara R, Tsutaki A, Lee K, Ochi E, Nakazato K.
    • Journal Title

      Physiological Research

      Volume: 61(5) Pages: 527-35

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic strain-dependent protein metabolism and muscle hypertrophy under chronic isometric training in rat gastrocnemius muscle2012

    • Author(s)
      Kobayashi K, Ogasawara R, Tsutaki A, Lee K, Ochi E, Nakazato K
    • Journal Title

      Physiol Res

      Volume: 61(5) Pages: 527-35

    • Related Report
      2013 Final Research Report
  • [Presentation] 間欠的低周波電気刺激によるタンパク質合成関連シグナルについての検討2013

    • Author(s)
      蔦木 新, 小笠原 理紀, 李 基赫, 鴻崎 香里奈, 小林 幸次, 中里 浩一
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      東京都港区
    • Year and Date
      2013-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 間欠的低周波電気刺激によるタンパク質合成関連シグナルについての検討2013

    • Author(s)
      蔦木 新, 小笠原 理紀, 李 基赫, 鴻崎 香里奈, 小林 幸次, 中里 浩一
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      日本教育会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット腓腹筋における低周波電気刺激下での等尺性収縮は筋肥大を誘発する2012

    • Author(s)
      蔦木 新, 小笠原 理紀, 小林 幸次, 鴻崎香里奈, 中里 浩一
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜県岐阜市
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] レジスタンストレーニングによる筋肥大にはタンパク質分解抑制が重要である2011

    • Author(s)
      小林 幸次, 越智 英輔, 小笠原 理紀, 蔦木新, 李 基赫, 中里 浩一
    • Organizer
      第66回日本体力医学会
    • Place of Presentation
      山口県下関市
    • Year and Date
      2011-09-16
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Remarks]

    • URL

      http://www.nittai.ac.jp/department/exphys/

    • Related Report
      2013 Final Research Report
  • [Remarks] 日本体育大学運動生理学研究室

    • URL

      http://www.nittai.ac.jp/department/exphys/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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